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Nortrel 1/35 Review

Nortrel 1/35 is a combination oral contraceptive containing female hormones known as ethinyl estradiol and norethisterone. The drug is used to prevent pregnancy.


Indications for use

  • Contraception.

Mechanism of action

The drug has a contraceptive effect. Nortrel 1/35 contains the optimal ratio of two hormones – progestogen (norethisterone) and estrogen (ethinyl estradiol). It suppresses the production of gonadotropic (regulating the activity of the sexual glands) hormones, suppresses the maturation of the follicle (the structural and functional element of the ovary), inhibits ovulation (the exit of a mature egg from the ovary). The drug does not affect the lipid (fat) metabolism.

Dosage and mode of application

Each Nortrel 1/35 pack contains 21 active pills (ethinyl estradiol + norethisterone) and 7 inert pills (no hormones).

Take 1 pill per day, orally, for 21 days. Menstrual bleeding occurs 2-3 days after you begin taking inert pills with no medication. Start taking pills on the first day of your menstrual peri0od. The drug should be taken at the same time of a day.

Begin a new pack of contraceptive without intervals.

Side effects

In some cases, Nortrel 1/35 tablets can cause the following side effects:

  • headache;
  • gastralgia;
  • nausea;
  • vomiting;
  • engorgement of the mammary glands;
  • weight gain;
  • changes in libido;
  • depressed mood;
  • eyelid edema;
  • skin rash;
  • conjunctivitis;
  • visual impairment;
  • hearing loss;
  • thrombophlebitis;
  • thromboembolism;
  • generalized itching;
  • jaundice;
  • intermenstrual bleeding;
  • chloasma.


Do not use Nortrel 1/35 if you have (or ever had) any of the following conditions:

  • thrombophlebitis (venous wall inflammation with occlusion);
  • thromboembolic diseases (vascular obstruction);
  • cerebrovascular diseases;
  • coronary artery disease;
  • severe liver dysfunction;
  • neoplasms of the genitourinary system;
  • estrogen-dependent neoplasias;
  • uterine bleeding of unknown etiology.


Nortrel 1/35 can interact with some drugs. It’s recommended to avoid the following combinations:

  • barbiturates;
  • some antiepileptic drugs (carbamazepine, phenytoin);
  • certain antibiotics (such as ampicillin, rifampicin);
  • ethanol (regular excessive use);
  • hypoglycemic drugs.

Pregnancy and breastfeeding

Nortrel 1/35 is contraindicated for use during pregnancy and breastfeeding. If you get pregnant during the use of this hormonal contraceptive, the drug should be discontinued.

What if I miss a pill?

  • If you missed an inert pill, discard it and continue taking birth control pills at your usual time;
  • If you missed an active pill, take it as soon as possible. The interval between doses should not exceed 12 hours. If the interval is more than 36 hours, a reliable contraceptive effect is not guaranteed. Continue taking the pills and use additional non-hormonal methods of contraception during this menstrual period.


The risk of cardiovascular complications on the background of taking oral contraceptives increases with smoking (especially in women over 35 years).

Before taking Nortrel 1/35 pills, it is necessary to consult the gynecologist.

The drug should be canceled with the following symptoms:

  • inflammation of the vein wall;
  • clotting of blood vessels;
  • vascular obstruction;
  • bloating;
  • unusual pain in the legs;
  • chest pain when breathing or coughing;
  • heavy feeling in the chest;
  • migraine headaches;
  • sudden hearing and vision impairments;
  • motor disorders.

The drug is discontinued 6 weeks before the planned surgical procedures. The risk of thrombosis increases with high blood pressure.

The drug is withdrawn with hepatitis, jaundice, itching, cholestasis, frequent epileptic seizures, primary or secondary porphyria.

Digestive disorders such as vomiting or diarrhea can reduce the contraceptive effect of Nortrel 1/35, so if you have these disorders, take an additional pill of this drug. If these symptoms are long-term, you should temporarily use additional barrier methods of contraception.


I was always very afraid of becoming pregnant unplanned. Nortrel 1/35 tablets are taken one at a time, preferably at the same time. You need to take it from the first day of the cycle. It is one of the best means of contraception. For me, this is the most convenient way of protection if the partner is permanent. This drug does not protect against various sexually transmitted diseases. I took this drug for about 2 years at 20 years old. Then I noticed only one side effect - nausea. In general, I will definitely recommend Nortrel 1/35. In comparison with other similar drugs, this one is affordable, performs its main function.
- Katie

In general, I liked this drug. I revealed two side effects from Nortrel 1/35 - my appetite and aggressiveness increased greatly. Nausea, swelling, fatigue were not observed. Menstruation came exactly on the day that my gynecologist-endocrinologist spoke about, so I put the drug a 4-star rating and recommend taking it, but only as prescribed by the doctor.
- Madison

Before the course, I read a lot of reviews, bad ones prevail. This review tells about my experience. My gynecologist prescribed me Nortrel 1/35. For several years now, I have a recurrent endometrial polyp. After each operation, various hormonal drugs and birth control pills were prescribed. Nothing helped. During the cycle, constantly spotting was observed. This year, after another operation, the doctor decided to try Nortrel 1/35. I take it in the minimum dose - 1 tablet per day. So, there are no secretions. I do not observe weight gain, mood changes, headaches, increased appetite. And no discharge either. For me, this is a big plus.
- Ava

My periods are unstable since the first time it appears. The first time gynecologist asked to wait 3 years, periods established without any therapies. But a stressful situation happened in my life and the menstrual delay came back. The first time the drug helped me, although the doctor scared me that if the bleeding starts or the condition worsens, I will need to call an ambulance, and not endure. But thank God, Nortrel 1/35 helped me adjust periods. I hope I forget about this problem forever.
- Alexandra

Since my first women's day at the age of 14, I have problems. The first cycle seems to be bleeding. A couple of years I suffered from the inconstancy of my periods. My cycle, instead of 28 days, was only 16-18 days. Menstruation itself is standard 7 days and very plentiful. It seems to me that I have tried many different COCs and even the vaginal ring, which causes bleeding, as well. COC no longer helped me to overcome plentiful bleedings. The doctor prescribed me Nortrel 1/35 and finally, my cycle returned to normal. Now I forgot what the problems with the periods are + protection from unwanted pregnancy is always a big advantage.
- Isabella

There are no universal tablets for everyone, it is necessary to choose COC individually, in accordance with the body reactions. Now I switched to tablets with 35 mcg of Ethinyl estradiol and 1 mg of norethisterone. I was afraid of taking such a high hormone dose. But micro and low-dose drugs are not fit me. I have constant bleeding. Therefore, my gynecologist and I carefully selected a drug that would not cause side effects. Now I am pleased with the result. I cannot definitely recommend this drug to everyone, consult your doctor before starting the course.
- Rebecca

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