Microgestin 24 Fe is a monophasic microdose contraceptive pills. It is prescribed to control birth.
Indications for use
Microgestin 24 Fe is prescribed in the following cases:
- hormonal birth control;
- moderate acne (acne vulgaris);
- severe premenstrual syndrome.
Mechanism of action
Microgestin 24 Fe is a combined hormonal birth control obtaining anti-aldosterone and anti-androgenic properties. The contraceptive effect of hormonal combined oral birth control drugs is achieved on the following factors. One of these actions lies in the ovulation suppression changing in the cervical secretions properties. It becomes much more difficult to enter the uterine cavity for spermatozoa.
Mode of application and dosage
Microgestin 24 Fe is prescribed as a 28-course. Every pill should be taken daily at one and the same time washed down with a small amount of water. The menstruation will start the 2nd – 3rd day when taking placebo pills. If the menstruation doesn’t come in the stated period of time it is necessary to consult a doctor to exclude pregnancy.
There are the following contraindications for the intake of Microgestin 24 Fe:
- high risk of venous or arterial thrombosis;
- current or prior venous and arterial thrombosis and thromboembolism;
- defined acquired or hereditary predisposition to venous or arterial thrombosis;
- migraine exacerbated by focal neurological symptoms found in the anamnesis;
- diabetes exacerbated by vascular dysfunctions;
- hepatic failure and severe hepatic disease including benign or malignant hepatic tumors;
- severe renal failure/acute renal failure;
- adrenal insufficiency;
- diagnosed or suggested hormone-dependent malignant dysfunctions (including genitals/mammary glands);
- vaginal hemorrhages of undefined etiology;
- confirmed or suggested pregnancy;
- hypersensitivity to any of the constituents of Microgestin 24 Fe;
- deficiency or intolerance to lactose, glucose-galactose malabsorption.
Side effects caused by Microgestin 24 Fe may be distinguished in accordance with the body systems like:
- infectious and parasitic diseases: vaginitis/vulvovaginitis, vaginal candidiasis or other fungal vulvovaginal infections, adnexitis, urinary tract infections, cystitis, mastitis, cervicitis, fungal infections, candidiasis, herpetic oral cavity disease, influenza, bronchitis, sinusitis, upper respiratory infections, viral infection.
- Benign, malignant and unspecified neoplasms (including cysts and polyps): uterine fibroids, breast lipoma.
- hematopoietic system: anemia.
- immune system: allergic reactions.
- endocrine system: virilism.
- metabolism and nutrition: increased appetite or anorexia.
- mental disorders: low mood; depression, mental dysfunctions, insomnia and other sleep disorders, aggression, mood change, reduced libido, increased libido.
- nervous system: headache, dizziness, migraine, ischemic stroke, cerebrovascular disorders, dystonia.
- organs of vision: dryness of the eyes mucous membrane, irritation of the eyes mucous membrane, oscillopsia, visual impairment, poor tolerance to contact lenses.
- organ of hearing and labyrinth disorders: sudden hearing loss, tinnitus, dizziness, hearing loss.
- cardiovascular system: hypertension, hypotension, cardiovascular disorders, tachycardia, venous and arterial thromboembolic dysfunctions, thrombophlebitis, diastolic hypertension, orthostatic circulatory dystonia, varicose veins, venous pathology.
- respiratory system: bronchial asthma, hyperventilation.
- gastrointestinal tract: abdominal pain, discomfort in abdomen/bloating, nausea, vomiting, diarrhea, gastritis, enteritis, dyspepsia.
- skin and subcutaneous tissues: acne, alopecia, rash (including macular rash), pruritus, allergic dermatitis, atopic dermatitis/neurodermatitis, eczema, psoriasis, hyperhidrosis, chloasma, hyperpigmentation, seborrhea, dandruff, skin pathology, skin reactions, orange peel, spider veins, urticaria, erythema nodosum, erythema multiforme.
- musculoskeletal system: back pain, discomfort in the muscles and skeleton, myalgia, limbs’ pain.
- genital organs and the mammary gland: pain in the mammary gland, discomfort, changes in the volume, duration and interval of menstrual bleeding, increased size of the mammary glands, swelling, acyclic bleeding, increased swelling, an increase in the mammary glands size, cervical dysplasia, uterine or breast cysts, fibrocystic mastopathy, dyspareunia, galactorrhea, menstrual disorders, allocations from the mammary glands.
- general health and disorders at the injection site: fatigue, asthenia, chest pain, peripheral edema, flu-like symptoms, inflammation, fever, irritability, fluid retention.
The combination between Microgestin 24 Fe and hepatic microsomal enzymes can result in breakthrough bleeding which may provoke the reduction in the birth control effect.
Agents that level up he active substances’ clearance in this combination include the following substances: phenytoin, barbiturates, bosentan, primidone, carbamazepine, rifampicin and HIV treatment agents (ritonavir, nevirapine and efavirenz). The following situation may take place with such substances as oxcarbazepine, topiramate, felbamate, griseofulvin, as well as preparations containing St. John’s wort.
When used in combination with this combination, many HIV protease or hepatitis C virus inhibitors and non-nucleoside reverse transcriptase inhibitors can either magnify or reduce the estrogen or progestin concentration in the blood.
What if I miss a dose?
Such recommendations may relate only to missing active pills. If a woman loses taking the pill for less than 24 hours, there is no reduction in the contraceptive effect. A woman should apply the skipped tablet as soon as possible.
If a woman skips the active pill for more than 24 hours, there is a considerable reduction in the contraceptive effect. The additional contraceptive methods should be used to prevent an unwanted pregnancy.
Microgestin 24 Fe and pregnancy
Microgestin 24 Fe is a direct contraindication during pregnancy. If a woman has a plan to bear a child, she should discontinue the drug at the most suitable time before conceiving. If pregnancy is diagnosed during the drug use, it should be withdrawn immense. But the extensive epidemiological trials have not discovered any magnified developmental defects’ risk in children born by women who took hormones before pregnancy. There are no also teratogenic effects when hormones were applied during the early stages of pregnancy.
Use of Microgestin 24 Fe during breastfeeding is contraindicated. The intake of hormonal contraceptive can decrease the volume of breast milk changing its composition. As a result, their application is not recommended during breastfeeding. It is necessary to withdraw the medication immediately. A small number of hormones can enter breast milk affecting the newborn body.