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Microgestin Fe 1.5/30 Review


Microgestin Fe 1.5 / 30 is a birth control drug with the following elements: norethindrone, ethinyl estradiol and Ferrum ferrate. Ferrum ferrate is included in the left 7 inert pills. It is prescribed for suppressing of an ovulation.

Contents:

Indications for use

Contraception

Mechanism of action

Microgestin Fe 1.5 / 30 is a low-dose monophasic hormonal birth control drug with the main ingredients: ethinyl estradiol and norethindrone. The contraceptive effect of this drug is supported mainly by the suppression of ovulation, enhanced viscosity of the cervical secretion. It also changes the endometrium. Women taking combined hormonal preparations feel the menstrual cycle improvement. It becomes more regular, less painful, the volume of the menstrual bleeding is reduced and the risk of iron deficiency anemia decreases.

Mode of application and dosage

The regiment of Microgestin Fe 1.5 / 30 includes a 28-days course. A 7-day break is not required. The pill should be taken at one and the same time. It should be washed down with a full glass of water. When you take 7 inert pills the menstruation will come.

Contraindications

  • Hypersensitivity to Microgestin Fe 1.5/30 components;
  • Diagnosed acquired or hereditary predisposition to venous or arterial thrombosis, including resistance to activated protein C, deficiency of antithrombin III, protein C deficiency, protein S deficiency, hyperhomocysteinemia, antibodies to phospholipids (antibodies to cardiolipin, lupus anticoagulant);
  • Thromboses (venous and arterial) presently diagnosed or in the medical history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders);
  • Conditions preceding thrombosis (including transient ischemic heart attacks, atrial fibrillation, angina) now or in the medical history;
  • Migraine with focal neurologic symptoms diagnosed no or in the medical history;
  • Diabetes mellitus;
  • Multiple or pronounced risk factors for venous or arterial thrombosis;
  • Pancreatitis with severe hypertriglyceridemia diagnosed at present or in the medical history;
  • Hepatic failure and liver disease of a severe form (before the normalization of liver function);
  • Benign or malignant hepatic tumors diagnosed at present or in the medical history;
  • Severe and/or acute kidney failure;
  • Identified hormone-dependent malignant diseases (including genitals or mammary glands);
  • Bleeding of unknown origin;
  • Hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
  • Pregnancy either diagnosed or suspected;
  • Lactation period.

Side effects

  • Immune system: rarely – bronchial asthma, hypersensitivity reactions.
  • Nervous system: often – headache.
  • Mental disorders: often – depressive condition; infrequently – a change in libido.
  • Hearing organ: rarely – hearing loss.
  • Central nervous system: often – migraine; infrequently – increased blood pressure, lowering blood pressure; rarely – thromboembolism.
  • Digestive system: often – nausea; infrequently – vomiting, diarrhea.
  • Skin and subcutaneous tissues: infrequently – acne, eczema, itching; rarely – erythema nodosum, erythema multiforme.
  • Reproductive system and mammary glands: often – menstrual irregularities, acyclic bleeding, pain in the mammary glands, hypersensitivity of the breast, leucorrhoea, candidiasis vulvovaginitis; infrequently – an increase in the mammary gland, vaginitis; rarely – secretions from the mammary glands.
  • Other: infrequent – fluid retention, change in body weight.

Interactions

In the combined use of Microgestin Fe 1.5/30 with inducers of microsomal hepatic enzymes, especially cytochrome P450 enzymes, such as anticonvulsant drugs (eg, phenytoin, phenobarbital, carbamazepine), anti-infective drugs (eg rifabutin, rifampicin, efavirenz, nevirapine), barbiturates, aminoglutethimide, hydantoins and others, possibly accelerating the metabolism of norethisterone, reducing plasma concentrations and its effect and changing the notion of uterine bleeding.

Also, nelfinavir and ritonavir, although they are potent inhibitors, may, when combined with steroid hormones, exhibit inducing properties.

Herbal preparations, which include St. John’s wort, can stimulate the metabolism of norethisterone.

Inhibitors of microsomal hepatic enzymes (eg, cimetidine and others) can increase the concentration and enhance the effect of norethisterone.

What if I miss a dose?

If you miss a dose you should read the instructions given in the manual. You should also consult your doctor beforehand.

Microgestin Fe 1.5 / 30 and pregnancy

If the pregnancy is diagnosed during the treatment, the drug should be immediately discontinued.

The drug is contraindicated during the period of breastfeeding. It can reduce the amount of breast milk and change its composition. A small number of sex hormones and/or their metabolites can penetrate the breast milk.

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