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Wymzya Fe Review

Wymzya Fe is a combination hormone medication which is used to prevent pregnancy. The drug contains 21 norethindrone/ethinyl estradiol chewable tablets and 7 ferrous fumarate tablets).


Indications for use

  • Hormonal contraception.

Mechanism of action

Wymzya Fe contains norethindrone and ethinyl estradiol. These hormones prevent ovulation and prevent sperm from entering the uterus.

Dosage and mode of application

Each package contains 28 tablets:

  • 21 white active tablets each containing 0.4 mg norethindrone and 35 mcg ethinyl estradiol;
  • 7 brown non-hormonal tablets each containing 75 mg ferrous fumarate. They do not serve any therapeutic purpose.

Take the drug by mouth. Take a tablet whole or chew it before swallowing. If you prefer to chew tablets, drink a glass of water after. Follow the doctor’s advice and instructions for use printed on the leaflet. To reduce adverse reactions, take tablets with food. Take these tablets at the same time each day, for 28 days in a row, and in the order directed on the package. Do not take tablets more often than indicated.

If you using Wymzya Fe for the first time and you have not used another method of hormonal birth control, take the first tablet on the first Sunday following the onset of your period or on the first day of your period. For the first cycle of use, use an additional backup birth control (condoms, spermicide) for the first 7 days. If you start taking tablets on the first day of your period, you do not need to use an additional backup birth control for 7 days.

If you are switching from a 21-day pack of birth control pills, you should wait 7 days after your last pill before you start a new drug. You may have withdrawal bleeding during that week. If you are switching from a 28-day pack of birth control pills, you should start your first pack of Wymzya Fe on the day after your last tablet. You should not take breaks between packs. You may switch any day from a progestin-only pill and should start taking a new drug the next day. If you are switching from an implant or injection, you should take the first pill on the day of implant removal or the day the next injection would be done.


Symptoms of overdose may include passing out, trouble breathing,  nausea, vomiting, unusual vaginal bleeding. If you have overdosed norethindrone and ethinyl estradiol and have serious side effects, seek emergency medical care.

Side effects

Wymzya Fe side effects are usually mild and temporary. They may include:

  • headache;
  • nausea;
  • vomiting;
  • swelling of the ankles/feet, weight change;
  • sudden dizziness;
  • bloating;
  • breast tenderness;
  • missed/irregular periods;
  • an increase in blood pressure;
  • unusual changes in vaginal bleeding;
  • yellowing eyes/skin;
  • blood clots;
  • dark urine;
  • lumps in the breast;
  • fainting;
  • acyclic vaginal bleeding (spotting);
  • confusion;
  • mental/mood changes;
  • severe stomach/abdominal pain;
  • vision problems/changes;
  • worsening of migraines;
  • unusual sweating;
  • allergic reaction (rash, itching/swelling);
  • pain/swelling/warmth in the groin/calf;
  • slurred speech;
  • sudden shortness of breath;
  • weakness;
  • chest/jaw/left arm pain;
  • unusual headaches.

You may experience other adverse reactions not included in this list. In this case, consult your doctor immediately.


Do not use Wymzya Fe if you have any of the following conditions:

  • diabetes;
  • high blood pressure;
  • history of blood clots;
  • kidney disease;
  • gallbladder disease;
  • heart disease or recent heart attack;
  • liver disease;
  • migraine headaches;
  • high cholesterol;
  • an unusual or allergic reaction to estrogens, progestins, other medicines, foods, dyes, or preservatives;
  • smoke tobacco;
  • stroke;
  • pregnant or trying to get pregnant;
  • abnormal vaginal bleeding;
  • breastfeeding;
  • blood vessel disease;
  • breast, cervical, endometrial, ovarian, liver, or uterine cancer;
  • systemic lupus erythematosus.


Major Wymzya Fe interactions include:

  • drugs used to treat seizures (barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate);
  • products used to treat chronic hepatitis C (such as ombitasvir/paritaprevir/ritonavir with or without dasabuvir);
  • aromatase inhibitors (such as anastrozole, exemestane);
  • rifamycins (such as rifampin, rifabutin);
  • ospemifene;
  • tranexamic acid;
  • griseofulvin;
  • modafinil;
  • tamoxifen;
  • tizanidine;
  • HIV drugs (such as nelfinavir, nevirapine, ritonavir);
  • St. John’s wort preparations.

Bear in mind that hormonal preparations may alter the results of some laboratory tests (blood clotting factors, thyroid, and so on). Before having tests, tell your doctor that you are on pills.

This list is not complete. When using birth control pills. do not start taking any new medication without consulting a doctor.

Pregnancy and breastfeeding

It may take longer for you to conceive after you cancel hormonal contraception. Consult your doctor.

Do not use Wymzya Fe during pregnancy. If you become pregnant or suspect you may be pregnant, consult your doctor immediately. If you have recently had a baby or had a 2-trimester abortion, consult your doctor about other non-hormonal methods of birth control, and find out when it is safe to start using drugs containing norethindrone and ethinyl estradiol.

This contraceptive may decrease breast milk production. Sex hormones enter the breast milk and may have adverse effects on a nursing baby. Consult your doctor before breastfeeding.

What if I miss a pill?

Missing any of the 21 active pills increases your risk of becoming pregnant.

  • If you miss 1 active pill, take two pills on the day you remember. Then keep taking 1 pill a day until you finish the pack;
  • If you miss 2 active pills in a row in Week 1 or 2, take two pills a day for 2 days in a row. Then keep taking 1 pill each day until the pack is empty. Use a backup birth control method for at least 7 days following the missed pills;
  • If you miss 2 active pills in a row in Week 3, discard the remaining pills start a new pack the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking 1 pill each day until Sunday. Then discard the rest of the pack and start a new pack that same day;
  • If you miss 3 active pills in a row in Week 1, 2, or 3, discard the rest of the pack and start a new pack immediately if you are a Day 1 starter. If you are a Sunday starter, keep taking 1 pill per day until Sunday. Then discard the remaining pills and start a new pack immediately;
  • If you miss a non-hormonal brown pill, discard it and continue to take 1 brow pill until you finish the pack. You do not need back-up birth control if you miss a reminder pill.

If you miss 2 or more active pills, you may have spotting/unscheduled breakthrough bleeding during the month. If you miss your period for 2 months in a row, visit your doctor because you might be pregnant.


This drug cannot be used in females who have not started having menstrual periods.
As long as you take this contraceptive, you need to visit a doctor regularly (at least every 6 months).

Discontinue the use of Wymzya Fe if any of the listed conditions develop:

  • arterial or venous thrombosis;
  • sudden loss of vision;
  • diplopia;
  • papilledema;
  • breast cancer;
  • cervical cancer;
  • depression;
  • uncontrolled dyslipidemias;
  • intraepithelial neoplasia;
  • proptosis;
  • pancreatitis;
  • acyclic vaginal bleeding after 3 months of use;
  • retinal vascular lesions;
  • a significant increase in blood pressure;
  • unusual regular headaches;
  • stroke;
  • amenorrhea;
  • oligomenorrhea;
  • chloasma;
  • angioedema;
  • myocardial infarction.

Stop taking tablets at least 4 weeks before the scheduled major surgery followed by a prolonged bed rest.

Smoking women over the age of 35 years should not use this medication due to n increased risk of cardiovascular negative effects.

If you have diabetes, be careful when taking this drug since sex hormones may decrease glucose tolerance.

Wymzya Fe does not protect women and their partners from sexually transmitted diseases.

Store the pack at room temperature away from heat and moisture.

Keep out of reach of children and pets.

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