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Tri-Norinyl Review

Tri-Norinyl is a low dose oral contraceptive prescribed to control conception. This drug contains norethindrone and ethinyl estradiol (21 pills) and placebo pills (7).


Indications for use

Tri-Norinyl is prescribed to be used as the means for hormonal contraception.

Mechanism of action

This birth control drug is characterized as a combined oral contraceptive including ethinyl estradiol and norethindrone. At a therapeutic dose, norethindrone also has anti-androgen and weak anti-mineralocorticoid characteristics. This drug is intended to control the conception. The main effect of Tri-Norinyl is suppression of ovulation. It also changes the viscosity of cervical secretion which result is an impossibility for spermatozoa to enter the uterine cavity. A reduction in the risk of endometrial and ovarian cancer with combined oral contraceptives is confirmed.

Mode of application and dosage

Tri-Norinyl package includes 21 pills with active hormones content. It also contains 7 placebo pills containing no hormone. The regimen includes one active pill once a day for 21 days without any interruptions. A woman will have periods during the 4th week of the menstrual cycle. After you have taken the last placebo pills in the pack, begin taking the pills from a new pack the next day. If something wrong happens with your periods you are welcome to address your healthcare giver. If you vomit or diarrhea is observed every woman should apply additional backup means to protect herself from unwanted pregnancy.


Tri-Norinyl should not be taken in the presence of any of the conditions from the list below:

  • hypersensitivity to Tri-Norinyl;
  • the presence of vein thrombosis at present or in the medical history;
  • the presence of arterial thrombosis at present or in history;
  • the presence of severe or multiple risk factors for arterial thrombosis (diabetes mellitus with vascular complications, severe arterial hypertension, severe dyslipoproteinemia);
  • thrombosis precursors such as transient ischemic attack, stenocardia specified in the anamnesis;
  • exacerbated valvular heart disease, atrial fibrillation, arterial hypertension of uncontrolled condition;
  • cerebrovascular diseases currently or prior transferred;
  • severe surgical intervention complicated by a long-lasting immobilization;
  • smoking over the age of 35;
  • pancreatitis, inclusively of an experience of severe hypertriglyceridemia;
  • severe hepatic disease currently or prior transferred;
  • hepatic tumors (benign or malignant) currently or in medical history;
  • hepatic failure;
  • severe chronic kidney failure or acute kidney failure;
  • malignant diseases of the reproductive system of hormone-dependent character (genital organs, mammary glands);
  • genital bleeding of unclear etiology;
  • migraine complicated by focal neurological symptoms in medical history;
  • diagnosed or suggested pregnancy;
  • breastfeeding period;
  • hereditary intolerance to galactose, lactase deficiency, glucose-galactose malabsorption.

Side effects caused by Tri-Norinyl

  • Nervous system: headache, emotional lability, depression, decreased libido, increased libido.
  • Endocrine system: violations of the menstrual cycle, intermenstrual bleeding, pain of the mammary glands; secretions from the mammary glands.
  • Organs of senses: hearing loss, intolerance to contact lenses.
  • Digestive system: nausea, abdominal pain, vomiting, diarrhea.
  • Skin and subcutaneous tissue: acne, eczema, skin rash, urticaria, erythema nodosum, erythema multiforme, pruritus, chloasma (especially if you have a history of pregnant chloasma).
  • Vascular system: migraine, increase or decrease in blood pressure, thrombosis (venous and arterial), thromboembolism.
  • Systemic disorders and complications at the injection site: an increase in body weight, fluid retention, weight loss.
  • Immune system: bronchospasm.
  • Reproductive system and mammary glands: acyclic vaginal bleeding (spotting or breakthrough uterine bleeding), tenderness, enlargement of the mammary glands, vaginal candidiasis, vaginitis, secretions from the mammary glands, an increase in vaginal secretions.


The combination of oral contraceptives with such drugs as enzyme inducers, some antibiotics can foster breakthrough bleeding and/or a decrease in contraceptive effectiveness.

It is necessary to consult a doctor if you notice any inclinations or symptoms of side effects caused by the combination of some medications.

Some medications may result in the reduction of the contraceptive reliability. This list includes the medications:

  • to treat epilepsy (for example, primidone, phenytoin, barbiturates, carbamazepine, oxcarbazepine, topiramate, felbamate);
  • to treat tuberculosis (for example, rifampicin, rifabutin) and HIV infection (for example, ritonavir, nevirapine);
  • antibiotics for the treatment of some other infectious diseases (for example, penicillin, tetracyclines, griseofulvin);
  • hypericum medications used predominantly in depressed mood treatment.

Oral combined contraceptives can affect the metabolism of other drugs (for example, cyclosporine and lamotrigine).

What if I miss a dose?

If a woman misses taking the pill for less than 12 hours, the contraceptive reliability is not decreased. In this case, a woman should apply a pill as soon as possible, the other pills are taken at the common regimen. If the delay in taking the pills is more than 12 hours, contraceptive reliability can be reduced considerably. In this case, it is necessary to take backup measures which help avoid an unwanted pregnancy.

Tri-Norinyl and pregnancy

It is a fact, Tri-Norinyl is contraindicated during pregnancy and breastfeeding. It is a scientifically proved fact that hormones may have some influence on the health of fetus if a woman takes birth control pills on the early stages of pregnancy. The effects are not significant. There is no risk to get developmental defects or severe abnormalities.

The breastfeeding period if one more contraindication. The rate for hormones to penetrate the breast milk is high enough. Hormones may change the composition of breast milk bringing the damage for newborn’s health.

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