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Ethinyl Estradiol / Norethindrone Review

Ethinyl Estradiol / Norethindrone is a birth control medication used to prevent ovulation and egg maturation. When taking this drug it becomes almost impossible for spermatozoa to enter the uterine.



Indications for use

Norethindrone And Ethinyl Estradiol is prescribed for treatment, control, prevention and improvement of the following diseases, conditions and symptoms:

  • pregnancy;
  • abnormal uterine hemorrhages.


Mechanism of action

The mechanism of action includes the following steps:

  • reduction of LH and FSH serum concentrations (an abrupt reduction in the frequency of impulsive gonadoliberin secretion, a decrease in the sensitivity to gonadoliberin, direct inhibition of hypophyseal FSH secretion by estrogen hormones);
  • an increase in LH in the middle of the menstrual cycle;
  • a decrease in the synthesis of estrogens and progesterone, as a result, providing a suppression of ovulation.
  • a violation of spermatozoa processing through the fallopian tube;
  • the formation of tight viscous mucus with cervical glands, making it difficult for sperm to penetrate the female genital tract, rebuilding of the endometrium, which makes it the most impossible for the fetal egg to attach to the uterus.


Mode of application and dosage

Adults, for an oral administration: 1 pill daily, starting from the 5th day of the menstrual cycle (that is, the 5th day after the onset of menstruation). The package is comprised of 21 tablets. After 21 tablets have been taken a 7-day break should be done.


Before you start applying this birth control pill, inform your doctor about the medications you are taking including food supplements (for example, vitamins, natural supplements, etc.). It is better to provide the information about possible allergic reactions, existing diseases and the current state of health (eg, pregnancy, upcoming operation, etc.). Side effects may become more expressed having a certain body state. The following contraindications are included in the list given in the instruction for use:

  • hepatic dysfunctions;
  • vaginal hemorrhages;
  • the age over 35 years;
  • smoking while taking the drug;
  • brain hemorrhages;
  • breast cancer in the anamnesis;
  • predisposition to blood clots;
  • monitoring blood glucose levels as this drug can increase sugar level;
  • Consult your doctor if you have the diagnosis of:
  • diabetes;
  • obesity;
  • vaginal bleeding of unclear etiology;
  • mild hypertension;
  • migraine;
  • mental disorders;
  • gallbladder dysfunctions;
  • regularly monitor breast condition and undergo gynecological exams while being on this medication.

Also among the contra-indications are the following phenomena:

  • women of reproductive age who do not use adequate methods of contraception;
  • pregnancy;
  • lactation;
  • hypersensitivity to the drug components;
  • children and adolescents under the age of 18 years, the efficacy and safety have not been established.
  • Caution should be used in patients who abuse alcohol or drugs.


Side effects

  • acne;
  • amenorrhea;
  • anaphylactic reaction;
  • cervical erosion;
  • cholestatic jaundice;
  • colitis;
  • dizziness;
  • dropsy;
  • nausea;
  • vomiting.

If you experience side effects not listed above, visit your doctor for advice. In addition, you can report the specified side effects to the local Food and Drug Administration to improve this list.


Norethindrone Acetate and Ethinyl Estradiol may interact with the following drugs and products:

  • Aminoglutethimide;
  • Carbamazepine;
  • Dicoumarol;
  • Hydrocortisone;
  • Itraconazole;
  • Phenobarbital;
  • Prednisolone;
  • Rifampin;
  • St. John’s wort.


What if I miss a dose?

If a dose is skipped, look through the instructions for use or contact your doctor for getting further instructions. If you use this drug to prevent pregnancy, for some time you may need to use some other methods of contraception to prevent unwanted pregnancy.

Ethinyl Estradiol / Norethindrone and pregnancy

This birth control pill is contraindicated during pregnancy. If you still breastfeed you are welcome to arrest taking Ethinyl Estradiol / Norethindrone. There is a study proving it can penetrate the breast milk damaging a baby health.

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