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Gildess Fe 1.5/30 Review

Gildess Fe 1.5/30 (ethinyl estradiol / norethisterone) is a combination birth control pill which contains 2 females hormones, that are used to prevent pregnancy.


Indications for use

  • Contraception;
  • Functional disorders of the menstrual cycle.

Mechanism of action

Ethinyl estradiol and norethisterone inhibit the hypothalamic-pituitary-ovarian system and block ovulation. The drug can both stimulate and delay menstrual bleeding.

Dosage and mode of application

Each pack contains 21 active tablets and 7 inactive tablets.

Take 1 tablet daily for 28 days in a row, without breaks and in the order specified on the blister. The interval between tablets should not exceed 36 hours.

The drug is most effective if taken at the same time of day, for example, in the evening.

When you take the last tablet from the blister, begin a new Gildess Fe 1.5/30 pack without interruption.

Side effects

In some cases, Gildess Fe 1.5/30 can cause the following side effects:

  • kidney disease, depression, decreased libido, decreased glucose tolerance, weight change;
  • arterial hypertension, myocardial infarction, cerebral circulation disorders, deep vein thrombosis, arterial thromboembolism, thromboembolism of pulmonary or other vessels, edema;
  • benign and malignant liver tumors, cervical and breast cancer;
  • cholestatic jaundice, Badda-Chiari syndrome, intrahepatic cholestasis, cholelithiasis;
  • nausea, vomiting, abdominal pain, flatulence, colitis, impaired appetite;
  • intermenstrual bleeding, spotting bloody discharge, amenorrhea, changes in the menstrual cycle, increased uterine fibroids, vaginal candidiasis, increased cervical secretion, cervical erosion, decreased libido, premenstrual syndrome;
  • soreness and sensation of tension, galactorrhea, engorgement, increase in size, reduction of lactation when taken immediately after birth;
  • erythema nodosum, skin rash, chloasma, exudative erythema, acne, seborrhea, alopecia, hirsutism, pigmentation on the face, hypertrichosis, pemphigoid (gestational herpes), melasma with a tendency to persist;
  • cataracts, lesions of the eye nerve, changes in the curvature of the cornea, a feeling of discomfort when wearing contact lenses;
  • headache, mood changes, irritability, depression, chorea, dizziness, migraine,
  • fluid retention, changes in body weight (decrease or increase), decreased glucose tolerance, changes in appetite;
  • decreased kidney function, hemolytic-uremic syndrome;
  • kidney disease, decreased libido.

If you have menstrual bleeding, continue taking the tablets. If it does not stop, you need to consult a doctor. If you have no menstruation after taking the last inactive tablet, you need to exclude pregnancy before beginning a new pack.


Gildess Fe 1.5/30 is contraindicated in the presence of any of the following conditions (present or in the history):

  • venous thrombosis;
  • arterial thrombosis or precursors of thrombosis;
  • presence of serious or multiple risk factors for arterial thrombosis;
  • arterial hypertension;
  • hereditary dyslipoproteinemia;
  • hereditary predisposition to venous or arterial thrombosis;
  • hypersensitivity to ethinyl estradiol / norethisterone / ferrous fumarate;
  • migraine with aura;
  • thromboembolism;
  • cerebrovascular disorders;
  • breast carcinoma and endometrium;
  • liver failure;
  • hemolytic anemia;
  • liver tumors;
  • otosclerosis;
  • cholestatic jaundice during pregnancy;
  • sickle-cell anemia;
  • cardiac ischemia;
  • bleeding from the genitals of unclear etiology;
  • postmenopausal women;
  • age under 18 years;
  • postpartum period (4 weeks);
  • pregnancy and breastfeeding.

With caution:

  • ulcerative colitis;
  • a family history of venous or arterial embolism;
  • prolonged immobilization or serious surgical operation;
  • smoking;
  • hyperlipidemia;
  • hypertension or obesity;
  • arterial hypertension;
  • mastopathy;
  • thrombophlebitis of superficial veins and varicose veins;
  • myoma of the uterus;
  • depression;
  • diseases of the liver and gallbladder;
  • epilepsy;
  • disorders of valvular heart apparatus with complications;
  • tuberculosis;
  • Crohn’s disease;
  • hypertriglyceridemia, including in family history;
  • systemic lupus erythematosus;
  • kidney diseases;
  • acute disruption of liver function during the previous pregnancy or previous intake of hormonal contraceptives;
  • disorders of the menstrual cycle.


  • St. John’s wort, barbiturates, carbamazepine, phenytoin, sulfonamides, pyrazolone derivatives, rifampicin can enhance the metabolism of steroid hormones;
  • Certain antibiotics (ampicillin or tetracycline) can accelerate the excretion of sex hormones and reduce the concentration of ethinyl estradiol;
  • Indinavir can increase the concentration of combined hormonal contraceptives in the blood;
  • Ritonavir can reduce the concentration of combined hormonal contraceptives in the blood;
  • When taking hypoglycemic drugs with Gildess Fe 1.5/30, you may need to adjust their dose.

Pregnancy and breastfeeding

The contraceptive is contraindicated during pregnancy and breastfeeding (lactation).

Ethinyl estradiol / norethisterone may reduce the amount and change the composition of breast milk. A small portion of contraceptive steroids can penetrate into breast milk.

What if I miss a pill?

If you miss an active tablet (1-21 tabs), take it immediately as soon as you remember it. The delay of up to 12 hours provides an effective contraceptive effect. The contraceptive effect of Gildess Fe 1.5/30 decreases if a delay in taking the nest dose exceeds 12 hours. In this case, throw away the missed tablet and continue taking the tablets at your usual time. The same scheme is applied if you missed 2 active tablets or more. In addition, you should use additional non-hormonal birth control methods until you have the next menstrual bleeding.

If you miss an inactive tablet (22-28 tabs), you may not worry and just throw it away since it contains no hormones proving a contraceptive effect.


Before taking hormonal contraceptives, you need to consult a gynecologist and undergo a thorough physical examination. Besides, a consultation is required every 6 months.

This drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Efficiency decreases with the regular use of ethanol.

Vomiting and diarrhea can also reduce a contraceptive effect of ethinyl estradiol / norethisterone.

The drug has no impact on the ability to drive vehicles and manage mechanisms.

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