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Loestrin 21 1.5 / 30 Review

Loestrin 21 1.5 / 30 is a monophasic contraceptive means. The suppression of an ovulation takes place when taking this birth control drug.


Indications for use

Loestrin 21 1.5 / 30 is prescribed as pregnancy warning.

Mechanism of action

This birth control is a combined, oral monophasic contraceptive gestagen-estrogen medication. It has the following features:

  • suppress an ovulation by blocking the secretion of follicle-stimulating and luteinizing hormones in the pituitary gland;
  • contribute to the secretory endometrium changes;
  • increase the viscosity of cervical mucus.

Sequential use of pills with the different amounts of gestagen (norethindrone) and estrogen (ethinyl estradiol) allows you to replenish and ensure the concentration of these hormones in the blood, close to physiological, followed by normalization of menstrual disorders.

Mode of application and dosage

The first pill should be taken on the 1st day of menstruation. The course lasts for 21 days. Then, a 7-day break should be followed. During this break, the menstruation will come. If it doesn’t happen it is better to consult a doctor to exclude the diagnosis of pregnancy.


Loestrin 21 1.5 / 30 has the following contraindications:

  • increased individual sensitivity to the drug constituents;
  • pregnancy;
  • breastfeeding;
  • hepatic failure;
  • hepatic tumors;
  • congenital hyperbilirubinemia;
  • chololith;
  • cholecystitis;
  • chronic colitis;
  • diagnosis or predisposition to severe cardiovascular and cerebrovascular changes, thromboembolism;
  • decompensated heart disorders;
  • hormone-dependent malignant neoplasms of the genital organs and mammary glands;
  • fat metabolism dysfunctions;
  • congenital hyperlipidemia;
  • uncontrolled arterial hypertension of medium and severe degree;
  • diabetes mellitus of severe form accompanied by retinopathy and microangiopathy;
  • sickle cell anemia;
  • chronic hemolytic anemia;
  • vaginal bleeding of unclear etiology;
  • migraine;
  • otosclerosis which worsened during a previous pregnancy;
  • idiopathic jaundice;
  • severe pruritus;
  • herpes during previous pregnant;
  • pancreatitis (including history), accompanied by severe hyperlipidemia;
  • jaundice due to a medication containing steroids;
  • smoking over the age of 35;
  • age over 40 years.

Side effects

Often side effects of Loestrin 21 1.5 / 30: nausea, vomiting, headache, breast tenderness, weight gain, increase in libido, depressed mood, intermenstrual bleeding.

Infrequent side effects: eyelid edema, conjunctivitis, impaired vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after any therapy discontinuation).

Rarely side effects are: an increase in triglycerides, blood glucose, decreased glucose tolerance, increased blood pressure, pulmonary embolism, thromboembolism, myocardial infarction, cardiovascular disorders, for example: cerebral vascular embolism, stroke, retinal thrombosis, mesenteric thrombosis, thrombosis of the brain, retinal thrombosis, mesenteric thrombosis, thrombosis of the brain, retinal thrombosis, mesenteric thrombosis, cerebral thrombosis, cerebral thrombosis, cerebral vascular embolism pelvic, lower extremities, thrombophlebitis of the deep veins of the lower extremities, hepatitis, jaundice, skin rashes, hair loss, increased vaginal secretion, candida vagina, fatigue, diarrhea.

Very rare side effects are: chloasma, hearing loss, generalized itching, jaundice, cramps of the gastrocnemius muscles, an increase in the frequency of epileptic seizures.


The use of Loestrin 21 1.5 / 30 requires caution when along with contraceptive taking the following preparations:

  • ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines, dihydroergotamine, tranquilizers, phenylbutazone, because they can weaken the contraceptive effect, at the same time it is recommended to use an additional, non-hormonal method of contraception;
  • anticoagulants, coumarin or indandione derivatives (it may be necessary to determine the prothrombin index and to change the dose of the anticoagulant);
  • tricyclic antidepressants, maprotiline, beta-blockers (possibly increasing their bioavailability and toxicity);
  • it may be necessary to change their dose if you take oral hypoglycemic drugs and insulin;
  • bromocriptine (reduced effectiveness of bromocriptine);
  • drugs with potential hepatotoxic effects, for example, dantrolene.

The risk of hepatotoxicity increases with age, especially in women over 35 years of age.

What if I miss a dose?

If the pill was skipped within the prescribed period, then the missed pill should be taken within the next 12 hours. In this case, there is no need to use additional methods of contraception. The remaining tablets are recommended to be taken at the usual time.

If the missing takes place for more than 12 hours, a woman should take the last missed pill and continue taking the drug as prescribed on a blister. In this case, in the next 7 days, it is necessary to apply additional methods of contraception (barrier methods, spermicides).

Loestrin 21 1.5 / 30 and pregnancy

Loestrin 21 1.5 / 30 is contraindicated during as it may bring damage to the female health. Moreover, it is mandatory to withdraw the medication if you are breastfeeding. Hormones may enter the breast milk and damage the health of the newborn.

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