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Alyacen 1 / 35 Review

Alyacen 1 / 35 is a low dose birth control means. This drug contains norethindrone, ethinyl estradiol to prevent pregnancy.


Indications for use

Alyacen 1 / 35 is prescribed as a contraceptive means.

Mechanism of action

Alyacen 1 / 35 belongs to a combined oral birth control. It includes ethinyl estradiol and norethindrone. The effect of this birth control pills is achieved due to several mechanisms:

  • suppression of ovulation;
  • decreased motility of the seed;
  • an abortive effect, a violation of the property of the uterine inner wall to perceive a fertilized egg, which results in the conceived embryo death.

The abortive effect is observed in approximately 10% of cases.

When using hormonal contraceptives with a low hormone rate, the likelihood of abortion increases.

The mechanism of action of birth control pills is maintained by the fact that a false signal is sent to the body that a woman is constantly pregnant for 12 months a year. Naturally, the body is not adjusted to this, and as a result of such a strong hormonal attack, all vital organs are struck. When these hormones are taken, all organs become targets of their action.

Mode of application and dosage

Alyacen 1 / 35 application lasts for 28 days. 21 pills contain active hormone dosages, 7 pills are placebo. Every active and inactive pill should be taken at one and the same time. It is recommended to wash down the pill with a sufficient amount of water. When taking placebo pills menstruation will start. If your menstruation doesn’t come you should immediately consult your doctor. The risk to become pregnant is high especially if you miss some pills during this course.


Alyacen 1 / 35 should not be applied in the presence of any of the below conditions:

  • hypersensitivity or any kind of allergy to drug components;
  • vein or arterial thrombosis and predisposition to it;
  • thrombosis precursors including transient ischemic attack, stenocardia especially if found in medical history;
  • complicated valvular heart disease, atrial fibrillation, uncontrolled arterial hypertension;
  • serious surgical intervention specified by long-lasting immobilization;
  • smoking over the age of 35;
  • hepatic failure;
  • cerebrovascular dysfunctions currently or found in medical history;
  • hereditary or acquired predisposition to venous or arterial thrombosis;
  • pancreatitis, inclusively of a history of severe hypertriglyceridemia;
  • diagnosed or suggested severe hepatic disease;
  • hepatic tumors;
  • severe chronic kidney failure or acute kidney failure;
  • disgnosed or suspected hormone-dependent malignant reproductive system dysfunctions (genital organs, mammary glands);
  • vaginal bleeding of unknown origin;
  • migraine complicated by focal neurological symptoms in medical history;
  • pregnancy;
  • lactation period.

Side effects

Nervous system:

  • often – headache, emotional lability, depression;
  • infrequently – decreased libido;
  • rarely – increased libido.

Endocrine system:

  • often – menstrual cycle violations, intermenstrual bleeding, pain in mammary glands;
  • rarely – secretions from the mammary glands.

Organs of senses: rarely – hearing loss, poor tolerance of contact lenses.

Digestive system:

  • often – nausea, abdominal pain;
  • infrequently – vomiting, diarrhea.

Skin and subcutaneous tissue: infrequently – chloasma, acne, pruritus, eczema, skin rash, urticaria, erythema nodosum, erythema multiforme.

Vascular system:

  • often – migraine;
  • infrequently – increase or decrease in blood pressure;
  • rarely – venous and arterial thrombosis, thromboembolism.

Systemic disorders and complications at the injection site:

  • often – body weight increase;
  • infrequently – fluid retention;
  • rarely – weight loss.

Immune system: rarely – bronchospasm.

Reproductive system and mammary glands:

  • often – acyclic vaginal bleeding (spotting or breakthrough uterine bleeding), tenderness, enlargement of the mammary glands, candidiasis of the vagina;
  • infrequently – vaginitis;
  • rarely – secretion from the mammary glands, an increase in vaginal secretion.


The combined application of oral contraceptives with medications from enzyme inducers group or some antibiotics can contribute to breakthrough bleeding. There is also a decrease in contraceptive reliability.

Please inform your doctor or pharmacist if you observe any severe negative effects or if you notice any negative effects that are not specified in the instructions.

Some medications may decrease this birth control drug effectiveness. The list includes preparations applied in the treatment of epilepsy (for example, primidone, phenytoin, barbiturates, carbamazepine, oxcarbazepine, topiramate, felbamate), tuberculosis (for example, rifampicin, rifabutin) and HIV infection (for example, ritonavir, nevirapine). Some antibiotics for the treatment of some other infectious diseases (for example, penicillin, tetracyclines, griseofulvin), as well as hypericum medications applied mainly in the treatment of depression, may decrease the reliability of contraceptive means.

Oral combined contraceptives can affect the metabolism of the following drugs such as cyclosporine and lamotrigine.

What if I miss a dose?

If a woman doesn’t take the medication for less than 12 hours, there is no reduction in the contraceptive effect. A woman is recommended taking a tablet as soon as possible, the next pills are taken at the usual time. If the delay in pills’ intake is more than 12 hours, contraceptive protection can be decreased. In this case, it is recommended to apply backup methods of contraception.

Note: the more pills you miss and closer the missed pills to the end of the circle the risk to become pregnant is high. If you are afraid to become pregnant it is necessary to follow the order specified on a blister without any interruptions.

Alyacen 1 / 35 and pregnancy

It is prohibited to take Alyacen 1 / 35 during pregnancy and lactation. There is no evidence that hormonal contraceptives can bring developmental damages to the fetus if their mothers were taking combined oral contraceptives before becoming pregnant. There is a high risk to damage the fetus if you take medications on the early stages of pregnancy.

If you are during lactation it is better to discontinue the medication as it may influence the composition of breast milk. The evidence of hormones’ penetration into breast milk is confirmed by numerous medical studies.

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