Zenchent Fe is a monophasic birth control drug. The course duration is 28 pills. It contains 2 female hormones progestin and estrogen.
Indications for use
Mechanism of action
Zenchent Fe belongs to a combined oral contraceptive drug containing norethindrone and ethinyl estradiol. The contraceptive effect is conducted by suppression of ovulation, an increase in the cervical secretions’ viscosity. The change in viscosity makes it difficult for spermatozoa to penetrate the uterine cavity. It also changes the endometrium that prevents fertilized egg implantation.
Mode of application and dosage
Zenchent Fe is prescribed for an oral application. The continuous application lasts for 28 days. 1 pill per day should be taken at the same time in the order specified on the package. The pill is washed down with water. The placebo pills (latest 7) will provoke menstruation. If it doesn’t come for several months it is necessary to address healthcare giver to exclude pregnancy.
Zenchent Fe is contraindicated in the following medical states about which your doctor should be informed:
- venous and arterial thrombosis and thromboembolism inclusively of deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular dysfunctions;
- multiple or severe risk factors for venous or arterial thrombosis;
- diagnosed or suggested conditions forgoing thrombosis inclusively of transient ischemic attacks, angina pectoris;
- diagnosed or suspected migraine with focal neurological symptoms;
- arterial hypertension of uncontrolled character;
- diabetes mellitus complicated by diabetic angiopathy;
- pancreatitis with severe hypertriglyceridemia now or in anamnesis;
- hepatic failure and liver disease of severe form;
- liver tumors: benign or malignant;
- severe dyslipoproteinemia;
- determined hormone-dependent malignant dysfunctions inclusively of genitals or mammary glands;
- bleeding of unknown origin;
- simultaneous use with remedies containing Hypericum perforatum;
- galactose intolerance, lactase deficiency or glucose-galactose malabsorption (since lactose is part of the drug);
- postmenopausal period;
- breastfeeding period;
- age up to 18 years.
- Infections and invasions: often – fungal infections, nasopharyngitis.
- Mental Health: often – depression.
- Nervous system: very often – a headache; often – migraine.
- Digestive tract: often – nausea, pain in the abdomen.
- Skin, subcutaneous and soft tissues: often – acne
- Musculoskeletal system and connective tissues: often – back pain.
- Reproductive system and the mammary gland: very often – painful menstrual bloody secretions/bleeding; often – metrorrhagia, breast sensitivity.
As with other COCs, the following side effects may develop for women:
- venous thrombosis;
- arterial thrombosis;
- cerebrovascular disorders;
- increased blood pressure;
- liver tumor;
- impaired liver function;
- impaired glucose tolerance or the effect on peripheral insulin resistance;
- acute pancreatitis;
- visual impairment;
The interaction of oral contraceptive drugs with some medications can result in breakthrough bleeding. There is also a decrease in contraceptive reliability.
Such medications are:
- phenytoin, bosentan, vemurafenib, barbiturates, primidone, carbamazepine, rifampicin, rifabutin;
- oxcarbazepine, topiramate, felbamate, griseofulvin and preparations containing St. John’s wort;
- HIV protease inhibitors (for example, ritonavir) and NNIOT (for example, nevirapine), and combinations thereof;
- some antibiotics (for example, penicillin and tetracycline).
What if I miss a dose?
The reliability of the drug may decrease if a woman misses taking a pill containing norethindrone and ethinyl estradiol, and especially if a woman forgets taking the first pills from the blister.
If the delay in taking the drug was less than 12 hours, the contraceptive reliability is not affected. A woman should apply a tablet as soon as possible, the next tablet is applied at the time preferred.
If the missing of one or several active pills is for more than 12 hours, the contraceptive reliability may be decreased. It is necessary to use backup birth control methods.
In this case, a woman should be guided by the following 2 main regulations:
- the drug should be taken for more than 7 days without interruptions;
- it takes 7 days of long-lasting application of pills to maintain significant suppression of the hypothalamic-pituitary-ovarian regulation.
Zenchent Fe and pregnancy
Zenchent Fe is contraindicated during pregnancy as it may result in developmental defects of the future newborn. It is also required to withdraw the medication during breastfeeding.