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Blisovi Fe 1.5/30 Review

Blisovi Fe 1.5/30 is a medication which is used for hormonal contraception. The drug contains a combination of 2 female hormones: ethinyl estradiol and norethisterone.


Indications for use

Blisovi Fe 1.5/30 is used to prevent pregnancy, treat acne. It can be used for other reasons under a doctor’s prescription.

Mechanism of action

The drug inhibits ovulation (the release of a mature egg from the ovary). In addition, it helps to increase the production of more viscous cervical mucus, which hampers the penetration of sperm into the uterus. Under the influence of ethinyl estradiol and norethisterone, unfavorable conditions are created for implantation of a fertilized egg in the endometrium (the inner layer of the uterus).

Dosage and mode of application

Each pack of Blisovi Fe 1.5/30 contains 21 pink tablets of ethinyl estradiol and norethisterone and 7 brown inert tablets containing ferrous fumarate. These 7 tablets do not have any therapeutic effect and serve as “reminders” to facilitate ease of daily drug administration.

To achieve the maximum contraceptive effect, the tablets must be taken according to the instructions, at intervals not exceeding 24 hours.

You can either start taking tablets on Sunday following the onset of your menstruation or on the first day of your period.

  1. Sunday-Starters: Taking the first pink tablet on the first Sunday after your menstruation begins. Takes 1 pink tablet per day for 21 days. Then take 1 brown tablet per day for 7 days. When the pack is empty, begin a new course of contraception, without breaks. Follow the same regimen, You will start all subsequent cycles on Sunday;
  2. Day-1 Starters: The first day of your period is considered to be Day 1. Place the week sticker that corresponds to your Day 1 over the printed days on the blister. Starts taking 1 pink tablet per day. Then take 1 brown tablet per day for 7 days. Once you’ve finished the first cycle of contraception, begin a new pack without interruption. Use this regimen for all subsequent cycles.

The drug should be taken with a meal or at bedtime. Try not to miss tablets since this can reduce the contraceptive effectiveness of Blisovi Fe 1.5/30.


Serious negative reactions have not been reported following intake of large doses of ethinyl estradiol and norethisterone. Overdosage may cause vomiting, nausea, and vaginal bleeding.

Side effects

In some cases, Blisovi Fe 1.5/30 can cause side effects. Most of them are temporary and do not require discontinuation of the drug.

  • General: headache, nausea, painful menstruations, breast tenderness, vaginal candidiasis, abdominal pain, changes in mood, bacterial vaginitis, acne, abnormal uterine bleeding, weight gain;
  • Genitourinary: vaginal candidiasis, painful menstruations, breast tenderness/pain, bacterial vaginitis, abnormal vaginal bleeding, menorrhagia, metrorrhagia, vaginal hemorrhage, dysmenorrhea, dysfunctional uterine bleeding, ovarian vein thrombosis, amenorrhea, breakthrough bleeding, breast enlargement, vaginitis, breast secretion,, cervical secretion, diminution in lactation, spotting, cervical erosion changed, premenstrual syndrome, uterine fibroid disease exacerbated, vaginal infection, pollakiuria, dysuria, pelvic pain, ovarian cyst, pelvic fluid collection, nipple pain, nipple discharge, galactorrhea, fibrocystic breast change, breast disorder, breast mass, uterine leiomyomata size increased, cervical ectropion changed, endometrial hyperplasia, ovarian cyst, uterine enlargement;
  • Cardiovascular: high blood pressure, vein thrombosis, myocardial infarction, hypertension, arterial thromboembolism, thrombophlebitis, coronary artery thrombosis, palpitation, tachycardia, angina pectoris, hot flush, irregular heart rate;
  • Nervous system: headache, migraine, dizziness, cerebral hemorrhage, cerebral thrombosis, fainting, hyperesthesia, paresthesia, hypoesthesia, somnolence, sensory disturbance, transient ischemic attack, ischemic stroke, chorea, epilepsy exacerbated, dementia, hemiparesis;
  • Oncologic: hepatic adenoma, hepatic carcinoma, benign liver tumor, hemangioma of the liver, breast cancer, ovarian cancer, endometrial cancer, uterine cancer;
  • Endocrine: hypothyroidism, hyperthyroidism;
  • Gastrointestinal: nausea, vomiting, abdominal pain/cramps, bloating, colitis, dyspepsia, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, mesenteric thrombosis, constipation, pancreatitis;
  • Hepatic: liver disease, gallbladder disease, cholestatic jaundice, Budd-Chiari syndrome, cholelithiasis, cholecystitis;
  • Psychiatric: changes in mood, depression, anxiety, nervousness, sleep disorders, suicidal ideation, panic attack, libido changed, homicidal ideation, dissociation, bipolar disorder, mood disturbed, irritability;
  • Dermatologic: acne, hirsutism, loss of scalp hair, melasma, chloasma, erythema multiforme, erythema nodosum, hemorrhagic eruption, photosensitivity, pruritus, alopecia, generalized rash, allergic rash, skin discoloration, urticaria, angioedema, night sweats, angioedema, hirsutism, skin burning sensation, generalized erythema;
  • Respiratory: pulmonary embolism, asthma, dyspnea;
  • Hematologic: hemolytic uremic syndrome, anemia;
  • Immunologic: hypersensitivity reaction, anaphylactic/anaphylactoid reaction;
  • Ocular: corneal curvature change/steepening, contact lens intolerance, cataracts, retinal thrombosis, vision disorders, corneal thinning, fungal infection;
  • Musculoskeletal: leg cramp, backache, myalgia, arthralgia, back pain;
  • Renal: impaired renal function, cystitis;
  • Metabolic: weight fluctuation, poor tolerance to carbohydrates, increased/decreased appetite, diabetes mellitus, hypoglycemia, hypocalcemia, increased triglycerides, abnormal blood glucose;
  • Other: cervical smear abnormal, weight gain, edema, fatigue, weakness, porphyria, Vitamin B6 deficiency, decreased weight, peripheral edema, malaise, chest pain.


Do not take Blisovi Fe 1.5/30 in the following cases:

  • an allergy to ethinyl estradiol, norethindrone, or ferrous fumarate);
  • an allergy to any other oral contraceptive, any other medications, products, or other substances;
  • a history of rash, hives, itching, shortness of breath, wheezing, cough, swelling of the face, lips, tongue, or throat;
  • a history of blood clots, breast cancer, diseased blood vessels in the brain or heart, a disease of a heart valve with problems, heart disease, angina, heart attack, stroke, liver disease, hypertension, liver tumor, severe headache or a migraine, diabetes;
  • a history of endometrial cancer, cancer of the cervix or vagina, vaginal bleeding of unknown origin;
  • 6 weeks before a scheduled surgery and prolonged bedrest;
  • established or suspected pregnancy;
  • breastfeeding period;
  • if you are taking ombitasvir, paritaprevir, and ritonavir;
  • a history of jaundice during pregnancy or jaundice caused by the use of hormonal contraceptives;
  • if you have not had your first period.


  • acitretin;
  • aminophylline / ephedrine / guaifenesin / phenobarbital;
  • amprenavir;
  • atropine / phenobarbital;
  • eslicarbazepine;
  • belladonna / ergotamine / phenobarbital;
  • bosentan;
  • encorafenib;
  • sugammadex;
  • brigatinib;
  • carbamazepine;
  • carfilzomib;
  • mycophenolate mofetil;
  • tranexamic acid;
  • dabrafenib;
  • dasabuvir / ombitasvir / paritaprevir / ritonavir;
  • phenytoin;
  • atropine / hyoscyamine / phenobarbital / scopolamine;
  • dyphylline / ephedrine / guaifenesin / phenobarbital;
  • ephedrine / phenobarbital / potassium iodide / theophylline;
  • ephedrine / phenobarbital / theophylline;
  • etretinate;
  • felbamate;
  • fosamprenavir;
  • fosphenytoin;
  • griseofulvin;
  • hemin;
  • hyoscyamine / phenobarbital;
  • telaprevir;
  • isoniazid / rifampin;
  • isoniazid / pyrazinamide / rifampin;
  • ivacaftor / lumacaftor;
  • arfilzomib;
  • lenalidomide;
  • phenobarbital;
  • aminophylline / ephedrine / phenobarbital / potassium iodide;
  • rifabutin;
  • mycophenolic acid;
  • primidone;
  • ombitasvir / paritaprevir / ritonavir;
  • oxcarbazepine;
  • pomalidomide;
  • rifapentine;
  • dantrolene;
  • st. john’s wort;
  • bexarotene;
  • thalidomide;
  • tizanidine;
  • boceprevir.

Pregnancy and breastfeeding

Blisovi Fe 1.5/30 is contraindicated for use during pregnancy. Exclude pregnancy prior to taking combination oral contraceptives. Stop taking the drug if pregnancy occurs when on the pills.

Breastfeeding women should not use this medication for birth control since its active substances are excreted into human milk and may affect the baby.

What if I miss a pill?

If you forget to take 1 or more active pink tablets, follow the instructions listed below:

1 tablet is missed: take it as soon as you remember, the next tablet is taken at the regular time

2 tablets are missed in a row (week 1 or 2): take 2 tablets as soon as you remember, take 2 tablets the next day, use an additional method of contraception for 7 days following the missed tablets.

2 tablets are missed in a row (week 3):

  • Sunday-Start: take 1 tablet per day until Sunday, then throw out the rest of the tablets and start a new pack immediately, use an additional method of contraception for 7 days following the missed tablets;
  • Day-1 Start: throw out the rest of the tablets, start a new pack that same day, use an additional method of contraception for 7 days following the missed tablets.

3 or more tablets are missed in a row:

  • Sunday-Start: keep taking 1 tablet per day until Sunday, then discard the rest of the tablets and a start new pack immediately, use an additional method of contraception for 7 days following the missed tablets;
  • Day-1 Start: throw out the rest of the tablets, start a new pack that same day, use an additional method of contraception for 7 days following the missed tablets.

The possibility of pregnancy increases with each missed pink tablet. The possibility of spotting/vaginal bleeding is also increased, especially if 2 or more pink tablets are missed in a row.

If you miss any of the 7 brown tablets in week 4, discard the missed tablets and keep taking 1 tablet each day until the pack is finished. You do not need a barrier method of preventing pregnancy during this time. Begin a new pack of Blisovi Fe 1.5/30 the next day after taking the last brown tablet.


Blisovi Fe 1.5/30 does not protect women from sexually-transmitted diseases.

The risk of cardiovascular complications increases with smoking (especially in heavy smokers over 35 years of age).

Before taking birth control pills, as well as every 6 months, you need to visit a gynecologist.

The drug must be discontinued immediately 6 weeks before the scheduled surgery and if the following symptoms appear: inflammation of the vein wall, vascular occlusion with a blood clot, distended veins, unusual pain in the legs, chest pain during breathing or coughing, tightness in the chest; severe migraine headaches, sudden hearing impairment, vision problems, movement disorders, hepatitis, jaundice, itching, cholestasis, aggravated epilepsy attacks, diseases associated with impaired metabolism of porphyrins/pigments), when you start taking barbiturates, rifampicin, ampicillin, griseofulvin, antiepileptic drugs, antidiabetic drugs.

The risk of thrombosis increases in women with high blood pressure.

Vomiting or diarrhea can lead to the withdrawal of ethinyl estradiol and norethisterone from the body, therefore, if you have vomiting or diarrhea 3-4 hours after taking a pink tablet, take an additional pill of Blisovi and use backup methods of contraception for 7 days.


I was taking this Blisovi Fe 1.5/30 for 3 months before I had to change it. I was living outside of my body. I started having panic attacks several times a week and it almost cost my relationship with my amazing boyfriend. I started to be very depressed that the smallest things made me blow out. I couldn't think ahead about my life or even the week without having a panic attack. I do not recommend this BC.
- Rose Jennings

I haven’t had great problems with Blisovi Fe 1.5/30. I started this contraceptive a few years ago and didn’t notice any side effects: acne or gaining a lot of weight. Pretty content with it!
- Sara Palmeri

Don’t mind the bad reviews! I was afraid to take this Blisovi Fe 1.3/30 contraceptive because of all the bad reviews. I took the risk anyway and I’ve had no horrible symptoms other women reported. I have PCOS, I feel like the hirsutism (unwanted facial hair) has slowed and I’m losing weight (although I am keeping on a diet)!
- Colleen Richardson

Last year, I took Blisovi Fe 1.5/30 as a 6-months course prescribed by the doctor. The goal was to regulate the menstrual cycle. These were my first COC. I took them strictly, as said in the instruction for use, from the first day of menstruation within 21 days. A break of 7 days is followed. During the first pack, my stomach was aching and there was spotting for almost an extra 10 days. But I read that it is a kind of adaptation. During the 6 months of admission, I did NOT gain weight, I did not notice any deterioration in my appearance. After the withdrawal of this drug, I again did not see any changes in my body. My first acquaintance with COC was wonderful. As conclusion, I recommend these pills. But, of course, if the doctor examines you and offers this hormonal drug.
- Kate

My husband and I decided that it would be more profitable to protect from unplanned pregnancy with oral contraceptives. At that time I was 22, did not give birth, there were no abortions. I read the reviews and still did it my own way - I began to take these pills. At the appointment with the gynecologist, I talked about the pills and the doctor prescribed Blisovi Fe 1.5/30 without any tests, convincing me that they would be effective. The cycle was established perfect - no failures. There was no pain before menstruation, although I had previously suffered from premenstrual syndrome. And now after the withdrawal, I suffer from all these. Pills had a big impact on my libido. Sexual desire disappears. From all these observations, I made the following conclusion: it’s better not to get into the hormonal contraception, the consequences are the most unpredictable.
- Aimee

The most desirable effect of this drug is to restore periods because this was my main problem. The issue was resolved from the first month of application, which I am extremely happy about. The advantages of this drug are as follows: the treatment is effective, quality, minimum side effects, not cause nausea, normalization of the periods, increased breast. I recommend Blisovi Fe 1.5/30, but start the course only after consulting a doctor.
- Sofia

I have long wanted to find a normal contraceptive, although I used to be an opponent of similar pills, and thought that I would never take them. In addition to the swelling, I did not notice any side effects. This effect remained for about 7 days. In the second week, acne began to disappear together with swelling. Instead of the usual 7 days menstruation - it lasts only for 3 days, the pain has become much less. At the moment, I’ve been taking them for 7 months, I’m feeling fine. Everything is okay. I recommend it.
- Maddison

I had a very unstable cycle and delays lasting 2-3 months. I was so nervous. Everything has changed when my gynecologist advised taking Blisovi Fe 1.5/30. I firmly did not believe that menstruation could come on time. In general, I bought my first pack of oral contraceptives. I carefully read the instructions, took the first pill on the first day when the menstruation started. I took the pills clearly at the same time at 10 pm. After 21 days of application, it was time to make a 7-day break and wait for menstruation. And they started on the third day. The next month, they arrived already on the 4th day and after 2 years, my periods start at one and the same time.
- Yasmin

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