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Sronyx Review


Sronyx (ethinyl estradiol/levonorgestrel) is an oral hormonal contraceptive which is used to prevent pregnancy.

Contents:

Indications for use

  • Oral contraception;
  • Functional disorders of the menstrual cycle (including dysmenorrhea, dysfunctional metrorrhagia, premenstrual syndrome).

Mechanism of action

The drug suppresses ovulation, increases the viscosity of the secretion of the cervix, which makes it difficult for sperm to penetrate the uterine cavity, and changes in the endometrium that prevent the implantation of a fertilized egg.

Dosage and mode of application

The drug is taken orally, without chewing, with a small amount of liquid.

Each Sronyx pack contains 21 active tablets (ethinyl estradiol + levonorgestrel ) and 7 inert tablets (no hormones).

Start taking tablets on the first day of your menstruation. Take 1 tablet per day for 28 days, preferably at the same time of day. During the intake of inert tablets, menstrual bleeding occurs. Begin the next package without interruption. It is important to comply with the order of taking tablets indicated on the blister. With good tolerability, the drug is taken as long as there is a need for contraception.

Side effects

All the side effects that occurred in 2% or more women taking Sronyx contraceptive are listed below:

  • fungal infections, nasopharyngitis;
  • depression;
  • headache, migraine;
  • nausea, pain in the abdomen;
  • acne;
  • backache;
  • painful menstrual-like bloody discharge / bleeding, metrorrhagia, sensitivity of the mammary glands;
  • increase in body weight;
  • venous thrombosis;
  • arterial thrombosis;
  • cerebrovascular disorders;
  • increased blood pressure;
  • hypertriglyceridemia;
  • liver tumor;
  • impaired liver function;
  • impaired glucose tolerance or influence on peripheral insulin resistance;
  • the emergence or deterioration of conditions, whose dependence on oral contraceptive use is not confirmed: Crohn’s disease, ulcerative colitis, epilepsy, migraine, uterine myoma, cervical cancer, gallbladder stones, porphyria, herpes during pregnancy, Sydenham’s chorea, hemolytic-uremic syndrome, cholestatic jaundice, hearing loss associated with otosclerosis, jaundice and / or itching associated with cholestasis;
  • dizziness;
  • cholecystitis;
  • acute pancreatitis;
  • impaired vision;
  • chloasma.

Contraindications

Absolute contraindications for Sronyx include:

  • hypersensitivity to ethinyl estradiol, levonorgestrel or other components of the drug;
  • thromboses (venous and arterial) and thromboembolism (present or in the history)(including deep vein thrombosis, pulmonary embolism, myocardial
  • infarction, cerebrovascular disorders);
  • conditions preceding thrombosis (present or in the history);
  • multiple or expressed risk factors for venous or arterial thrombosis;
  • hereditary or acquired predisposition to venous or arterial thrombosis: resistance to activated protein C, hyperhomocysteinemia, deficiency of antithrombin III, protein C deficiency, protein deficiency S, presence of antibodies to phospholipids (antibodies to cardiolipin, lupus anticoagulant);
  • migraine with focal neurologic symptoms (present or in the history);
  • uncontrolled arterial hypertension;
  • diabetes mellitus with diabetic angiopathy;
  • pancreatitis with severe hypertriglyceridemia (present or in the history);
  • hepatic insufficiency and severe liver disease (before the normalization of liver function tests);
  • liver tumors (present or in the history);
  • severe dyslipoproteinemia;
  • identified hormone-dependent malignant diseases (including genitals or mammary glands);
  • bleeding from the vagina of unknown origin;
  • simultaneous application with preparations of St. John’s wort perfumed;
  • intolerance to galactose, insufficiency of lactase or glucose-galactose malabsorption (because the composition of the drug includes lactose);
  • postmenopausal period;
  • pregnancy;
  • the period of breastfeeding;
  • age under 18 years (due to the lack of data on the effectiveness and safety of the drug in adolescent girls under 18 years of age).

If any of the above diseases or conditions develop against the background of taking Sronyx birth control pills, they should be immediately canceled.

With caution:

  • risk factors for thrombosis and thromboembolism: smoking, hereditary predisposition to thrombosis, overweight, dyslipoproteinemia, controlled Arterial
  • hypertension, migraine without focal neurological symptoms, uncomplicated heart valve disease;
  • other diseases in which peripheral circulation disorders may occur: diabetes mellitus without diabetic angiopathy, systemic lupus erythematosus, hemolytic-uremic syndrome, Crohn’s disease and ulcerative colitis, sickle cell anemia, phlebitis of superficial veins;
  • hypertriglyceridemia;
  • liver disease of mild and moderate severity with normal liver function tests;
  • diseases that first occurred or worsened during the previous pregnancy or against the background of the previous reception of sex hormones (jaundice, cholestasis, gallbladder disease, otosclerosis with hearing impairment, porphyria, herpes during pregnancy, Sydenham’s chorea);
  • hereditary angioedema, chloasma, depression, epilepsy.

Interactions

  • ampicillin, dihydroergotamine, phenylbutazone, chloramphenicol (can reduce the contraceptive effect (it is recommended to use an additional, non-hormonal method of contraception);
  • bromocriptine (decreased effectiveness of bromocriptine);
  • griseofulvin, carbamazepine, oxcarbazepine, primidone, rifampicin, topiramate, phenytoin (may lead to an increased clearance of ethinyl estradiol in levonorgestrel + ethinyl estradiol combination, which in turn can lead to breakthrough bleeding and / or a decrease in the contraceptive reliability of Sronyx. It’s recommended to use a barrier method of contraception for 7 days).

Pregnancy and breastfeeding

Sronyx is contraindicated in pregnancy and lactation (breastfeeding).

What if I miss a pill?

Take the missed tablet within the next 12 hours. If the interval between doses exceeds 36 hours, contraception is unreliable. In such cases, to prevent possible intermenstrual bleeding, continue taking tablets from the already started package, with the exception of the missed tablet(s).

If you missed pills, it is recommended to use an additional, non-hormonal method of contraception (for example, a condom).

This rule does not apply to the last 7 tablets in the package since they do not contain hormones.

Precautions

Before taking birth control pills, it is necessary to exclude pregnancy, to conduct a general medical examination and gynecological examination. Such examinations should be carried out regularly, every 6 months.

The use of oral contraception is not allowed until the liver functions are completely normalized.

Sharp pains in the upper abdominal areas, hepatomegaly and signs of intra-abdominal hemorrhage may indicate a liver tumor. In this case, discontinue using the contraceptive.

If you have vomiting or diarrhea, continue taking the drug and use an additional, non-hormonal contraceptive method.

Stop using the tablets at least 3 months before the planned pregnancy.

Oral contraceptives can alter the functional parameters of the liver, kidneys, adrenals, thyroid gland, blood coagulation factors and fibrinolytic factors, levels of lipoproteins and transport proteins.

Sronyx should be discontinued in the following cases:

  • migraine-like pains, unusually strong headaches;
  • acute deterioration of visual acuity;
  • suspicion of a thrombosis or a heart attack;
  • a sharp increase in blood pressure;
  • jaundice or hepatitis;
  • generalized itching;
  • increased epileptic seizures;
  • pregnancy.

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