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Iclevia Review

Iclevia is a birth control drug that suppresses ovulation and prevents unwanted pregnancy. It contains levonorgestrel and ethinyl estradiol. One therapy course lasts for 91 days.


Indications for use


Mechanism of action

Iclevia is a combined monophasic oral hormonal contraceptive. When applied, this drug inhibits the pituitary secretion of gonadotropic hormones. The contraceptive effect is associated with several mechanisms. As a progestin component, it contains a 19-nortestosterone derivative – levonorgestrel, which excels progesterone in the activity of the corpus luteum hormone (and the synthetic analogue of the latter – pregnin), and acts at the receptor level without preliminary metabolic transformations. The estrogen component is ethinyl estradiol. Under the influence of levonorgestrel, there takes place a blockade of the LH and FSH release from the hypothalamus, inhibition of pituitary secretion of gonadotropic hormones, which contribution to inhibition of maturation and the release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. It maintains a high viscosity of cervical mucus (it makes it difficult for sperm to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps to prevent the development of a number of gynecological diseases, including tumor nature.

Mode of application and dose

Iclevia is taken orally continuously for 91 days at 1 tablet a day at the same time in the order indicated on the package (blister). To achieve the greatest contraceptive effect, the drug should be taken in accordance with the recommendations and at intervals not exceeding 24 hours.


  • Severe liver disease;
  • Congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome, Rotor syndrome);
  • Cholecystitis;
  • The presence or history of severe cardiovascular and cerebrovascular diseases;
  • Thromboembolism and predisposition to them;
  • Malignant tumors (primarily breast cancer or endometrium);
  • Tumors of the liver;
  • Familial forms of hyperlipidemia;
  • Severe forms of arterial hypertension;
  • Endocrine diseases (including severe forms of diabetes mellitus); – sickle cell anemia;
  • Chronic hemolytic anemia;
  • Vaginal bleeding of unknown etiology;
  • Cystic mole;
  • Migraine;
  • Otosclerosis;
  • Idiopathic jaundice of pregnant women in history;
  • Severe skin itching of pregnant women;
  • Herpes pregnant;
  • Age over 40 years old;
  • Pregnancy;
  • Lactation;
  • Hypersensitivity to the components of the drug.

Side effects

Iclevia is usually well tolerated. Possible side effects of a transient nature that spontaneously disappear are:

  • nausea;
  • vomiting;
  • headache;
  • tenderness of the mammary glands;
  • changes in body weight and libido;
  • mood changes;
  • acyclic spotting;
  • eyelid edema, conjunctivitis, visual impairment, discomfort when wearing contact lenses;
  • With prolonged use, chloasma, hearing loss, generalized itching, jaundice, calf muscle cramps, an increase in the frequency of epileptic seizures can very rarely occur. Hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure, thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, candidiasis, fatigue, and diarrhea are rarely recorded.


Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can enhance the metabolism of steroid hormones contained in the preparation.

A decrease in contraceptive effectiveness can be found with the simultaneous administration with certain antimicrobials (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with a change in the intestinal microflora.

Simultaneous use with anticoagulants, coumarin or indandion derivatives provides an additional determination of the prothrombin index and a change in the dose of the anticoagulant may be required.

When using tricyclic antidepressants, maprotiline, beta-blockers, an increase in their bioavailability and toxicity is possible.

When using oral hypoglycemic drugs and insulin, it may be necessary to adjust their dose.

When combined with bromocriptine, its effectiveness is reduced .; When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years old.

What is I miss a dose?

The effectiveness of the drug may decrease if the patient miss taking a pill (containing ethinyl estradiol + levonorgestrel), and especially if the patient miss taking the first pill from a blister.

If the delay in taking the drug was less than 12 hours, contraceptive protection does not decrease. A woman should take the pill as soon as possible, the next pill is taken at the usual time.

If the application of the birth control pill is missed for over 12 hours, contraceptive protection may be reduced.

Iclevia and pregnancy

Iclevia is contraindicated in pregnancy and breastfeeding. If pregnancy is established while taking this birth control, the drug should be discontinued immediately. Extensive epidemiological studies have not revealed an increased risk of congenital malformations in children whose mothers received COCs before pregnancy, or teratogenicity, with random COCs in the early stages of pregnancy.

Taking COCs can reduce the amount of breast milk and change its composition, so their use is contraindicated until the discontinuation of breastfeeding. A small amount of the active ingredients of COCs and/or their metabolites that penetrate into breast milk may affect the newborn health.

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