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Myzilra Review

Myzilra is a triphasic low dose hormonal birth control. This drug is prescribed to prevent the unwanted pregnancy by ovulation suppression.


Indications for use

Myzilra is prescribed as a means for an oral contraception.

Mechanism of action

This is a low dose triphase oral contraceptive drug. Levonorgestrel limits the release factors of the hypothalamus known as luteinizing and follicle-stimulating hormones and follicle-stimulating hormones. It affects the secretion of the gonadotrophic hormones by the pituitary gland. Such an effect provides an inhibition of maturation and ovum release capable to be fertilized. The changes in the endometrium are also observed preventing the attachment of a fertilized egg.

Ethinylestradiol stimulates the viscosity of the cervical secretion. The result lies in the difficulty of the entering of the spermatozoa into the uterine cavity.

Mode of application and dosage

Myzilra is prescribed for an oral administration. The regimen includes a daily administration at one and the same time. It is washed down with a glass of water. Take 1 tablet a day continuously for 28 days. There is no need to make a 7-days break. Bleeding, as a rule, begins on day 2-3 after the placebo pills and may not finish before the start of the new package.


  • Hypersensitivity to any of Myzilra components;
  • Thrombosis (venous and arterial) and thromboembolism now or in the medical history (including, deep vein thrombosis, pulmonary embolism, myocardial infarction), cerebrovascular disorders;
  • Conditions preceding thrombosis (including, transient ischemic attacks, angina pectoris) are presently diagnosed or in the anamnesis;
  • Multiple or expressed risk factors for venous or arterial thrombosis;
  • Long-term immobilization, extensive surgical intervention, operative interventions on the lower limbs, extensive injuries.
  • Migraine with focal neurologic symptoms currently diagnosed or in the medical history;
  • Diabetes mellitus with vascular complications;
  • Pancreatitis with severe hypertriglyceridemia at present or in the anamnesis;
  • Hepatic insufficiency and severe liver disease including liver tumors;
  • Diagnosed or suggested hormone-dependent malignant diseases (including genitals or mammary glands);
  • Vaginal bleeding of unknown origin;
  • Pregnancy: diagnosed or suspected;
  • Breastfeeding period;
  • Lactase deficiency, sugars/isomaltase deficiency, fructose and lactose intolerance, glucose-galactose malabsorption.

Side effects

Organ System Often (≥1/100) Not Often (≥1/1000 и <1/100) Rare (<1/1000)
Vision organs intolerance to the contact lenses when waring
Gastrointestinal system nausea, abdominal pain vomiting, diarrhea
Immune system allergic reactions
Common side effects increase in a body weight decrease in weight
Metabolic system fluid retention
Nervous system headache migraine
Mental Disorders mood swings, emotional lability decrease in libido increase in libido
Reproductive system and mammary glands pain in mammary glands, tenderness of mammary glands megalomastia vaginal secretion, mammary glands secretion
Skin and subdermal tissues rash, urticarial fever erythema nodosum, erythema multiform


Influence on hepatic metabolism: the application of drugs that induce microsomal liver enzymes can result in an increase in the sex hormones clearance. The following medicines are included in the list: phenytoin, barbiturates, primidone, carbamazepine, rifampicin; There are also suggestions for oxcarbazepine, topiramate, felbamate, griseofulvin, and preparations containing St. John’s wort (Hypericum perforatum).

HIV protease inhibitors (eg, ritonavir) and non-nucleoside reverse transcriptase inhibitors (eg, nevirapine) and their combinations may also influence the hepatic metabolism.

Influence on enterohepatic recirculation: according to certain trials, some antibiotics (eg, penicillin and tetracyclines) can reduce intestinal hepatic recycling of estrogens, thereby decreasing ethinyl estradiol concentration.

During the administration of drugs that affect microsomal liver enzymes, and within 28 days after their discontinuation, the barrier method of contraception should be used.

During the reception of antibiotics (such as penicillin and tetracyclines) and within 7 days after their discontinuation, the barrier method of contraception should be applied additionally. If the period of the barrier method of contraception use ends later than the tablets in the package, you need to start the next package of this birth control without any breaks in taking the tablets.

What if I miss a dose?

  • If a woman skips one pill for a period of fewer than 12 hours Myzilra pill should be taken immediately. The contraceptive effect is not reduced.
  • If the delay lasts for more than 12 hours a woman should take the pill simultaneously. The chance of the contraceptive effect reduction is increased. As a result, it is recommended to use additional barrier methods.

Myzilra and pregnancy

Myzilra is not prescribed during pregnancy and lactation. If pregnancy is diagnosed during the administration of this triphasic birth control drug, it should be immediately discontinued. Taking combined oral contraceptives can reduce the amount of breast milk and change its composition, so, as a rule, their use is not recommended during lactation.

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