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Aubra EQ Review



  • Oral contraception;
  • Functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia);
  • Premenstrual syndrome.

Mechanism of action

Aubra EQ is a combined hormonal contraceptive for oral administration. The contraceptive effect is achieved due to several mechanisms. Under the influence of levonorgestrel, a blockade of release of releasing factors (LH and FSH) of the hypothalamus takes place. It provides an inhibition of pituitary secretion of gonadotropic hormones, which contributes to inhibition of maturation and the release of an egg ready for fertilization (ovulation). Ethinyl estradiol helps keep high viscosity of cervical mucus, which makes it difficult for sperm to attach to the uterine cavity.

Mode of application and dosage

Oral administration. One Aubra EQ tablet should be taken 1 time per day, starting from 1 or 5 days of the menstrual cycle for 21 days, followed by a 7-day interval.


  • Thrombosis (venous and arterial) and thromboembolism currently diagnosed or in history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders);
  • Conditions preceding thrombosis (including transient ischemic attacks, angina pectoris) at present or in history;
  • Multiple or severe risk factors for venous or arterial thrombosis;
  • Hereditary or acquired predisposition to venous or arterial thrombosis;
  • Migraine with focal neurological symptoms at present or in history;
  • Uncontrolled arterial hypertension;
  • Diabetes mellitus with diabetic angiopathy;
  • Pancreatitis with severe hypertriglyceridemia at present or in history;
  • Liver failure and severe liver disease (until normalization of liver function tests);
  • Liver tumors (benign or malignant) at present or in history;
  • Severe dyslipoproteinemia;
  • Identified hormone-dependent malignant diseases;
  • Vaginal bleeding of unknown origin;
  • Pregnancy;
  • Breastfeeding;
  • Postmenopausal period;
  • Age up to 18 years;
  • Simultaneous use with perforated Hypericum;
  • Hypersensitivity to the components of the birth control drug.

Side effects

  • The reproductive system: possibly – tenderness of the mammary glands, decreased libido, intermenstrual bleeding; rarely – increased vaginal discharge, vaginal candidiasis.
  • The digestive system: possibly – nausea, vomiting; rarely – jaundice, hepatitis, liver adenoma, gallbladder disease (e.g. cholelithiasis, cholecystitis), diarrhea.
  • The side of the nervous system: possibly – headache, depressed mood; rare (prolong use) – an increase in the frequency of epileptic seizures.
  • The sensory organs: in some cases – edema of the eyelids, conjunctivitis, visual impairment, discomfort when wearing contact lenses; with prolonged use it is very rare – hearing loss.
  • The side of metabolism: possibly – an increase in body weight; rarely – an increase in the concentration of triglycerides, glucose in the blood, a decrease in glucose tolerance.
  • The skin and subcutaneous tissues: possibly – chloasma; rarely – skin rash, hair loss; very rarely with prolonged use – generalized itching.
  • Other: rarely – increased fatigue, increased blood pressure, thrombosis and venous thromboembolism; rare (prolonged use) – spasms of the calf muscles, voice hoarseness.


  • Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can enhance the metabolism of these birth control pills.
  • A decrease in contraceptive effectiveness can be found with the simultaneous administration with certain antimicrobials (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines). It is associated with a change in the intestinal microflora.
  • The simultaneous use with anticoagulants, coumarin or indandion derivatives provides an additional determination of the prothrombin index. A change in the anticoagulant dose adjustment may be required.
  • When using tricyclic antidepressants, maprotiline, beta-blockers, an increase in their bioavailability and toxicity is possible.
  • When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.
  • When combined with bromocriptine, its effectiveness decreases.
  • When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years old.

What if I miss a dose?

If you miss a dose, you must take the drug within the next 12 hours. If an interval is over 36 hours, a reliable contraceptive effect is not guaranteed. During this period, it is recommended to use other non-hormonal methods of contraception.

Aubra EQ and pregnancy

Aubra EQ is contraindicated during pregnancy and lactation.

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