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Aubra Review


Aubra is a combination contraceptive which contains ethinyl estradiol and levonorgestrel, that are used to prevent pregnancy.

Contents:

Indications for use

  • Contraception.

Mechanism of action

Ethinyl estradiol and levonorgestrel suppress ovulation, increase the viscosity of the secretion of the cervix, which makes it difficult for spermatozoa to penetrate into the uterine cavity, and change the endometrium which prevents the implantation of a fertilized egg.

Dosage and mode of application

Take 1 tablet orally every day in the order indicated on the blister, at the same time.

Take the drug for 28 days in a row. Once you have taken the last tablet, begin a new Aubra pack without interruption. Bleeding cancellation begins 2-3 days after you have taken the last active pill in the package.

Take the first tablet on the first day of your menstrual bleeding. If you start taking the tablets on the 2-5 day of the cycle, you need to use additional barrier contraception within 7 days.

After delivery, you need to start taking the contraceptive on day 21-28. If the time has elapsed, you should use an additional barrier method of contraception. Before taking the drug, you need to exclude pregnancy. For this, it’s recommended to wait for the first menstruation

Side effects

In some cases, Aubra tablets can cause the following side effects:

  • reproductive system: engorgement of the mammary glands, decreased libido, intermenstrual bleeding, increased vaginal discharge, candidiasis of the vagina;
  • digestive system: nausea, vomiting, jaundice, hepatitis, liver adenoma, gallbladder disease (for example, cholelithiasis, cholecystitis), diarrhea;
  • nervous system: headache, depressed mood, an increase in the frequency of epileptic seizures;
  • senses: eyelid edema, conjunctivitis, visual impairment, discomfort when wearing contact lenses, a hearing loss;
  • metabolism: an increase in body weight, an increase in the concentration of triglycerides, glucose in the blood, a decrease in glucose tolerance;
  • skin and subcutaneous tissues: chloasma, skin rash, hair loss, generalized itching;
  • other: increased fatigue, increased blood pressure, thrombosis and venous thromboembolism, cramps calf muscles, coarsening of the voice.

Contraindications

Aubra is contraindicated for use in the following conditions or diseases:

  • cardiovascular diseases (heart valve lesions, rhythm disturbances, hypertension, ischemic heart disease);
  • thrombophlebitis, thrombosis and thromboembolism;
  • migraine with focal neurological manifestations;
  • long-term immobilization and surgical operations on the legs;
  • breast cancer;
  • myometrium carcinoma;
  • estrogen-dependent tumors;
  • liver disease;
  • pancreatitis with severe hypertriglyceridemia;
  • diabetes mellitus with vascular lesions;
  • pregnancy and lactation;
  • uterine bleeding, unspecified genesis;
  • epilepsy;
  • impaired renal function;
  • hemophilia and low blood coagulability;
  • severe immune diseases;
  • excessive body weight;
  • hypersensitivity to ethinyl estradiol/levonorgestrel.

With caution:

  • risk factors for thrombosis and thromboembolism: smoking, hereditary predisposition to thrombosis (a history of thrombosis, myocardial infarction or impaired cerebral circulation), overweight, dyslipoproteinemia, controlled arterial hypertension, migraine without focal neurological symptoms, uncomplicated heart valve disease;
  • diabetes mellitus without diabetic angiopathy, hemolytic uremic syndrome, Crohn’s disease and ulcerative colitis, sickle cell anemia, phlebitis of superficial veins;
  • hypertriglyceridemia;
  • liver disease of mild and moderate severity with normal liver function tests;
  • jaundice, cholestasis, gallbladder disease, otosclerosis with hearing impairment, porphyria, herpes during pregnancy, Sydenham’s chorea;
  • predisposition to angioedema, chloasma, depression, epilepsy.

Interactions

Below you can see medications that may interact with Aubra:

  • barbiturates, carbamazepine, phenytoin, sulfonamides, pyrazolone derivatives;
  • some antimicrobial agents (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines);
  • anticoagulants, coumarin or indanedione derivatives;
  • tricyclic antidepressants, maprotiline, beta-blockers;
  • oral hypoglycemic drugs and insulin;
  • bromocriptine;
  • drugs with a potential hepatotoxic effect (dantrolene).

Pregnancy and breastfeeding

Aubra is contraindicated for use during pregnancy and lactation period (breastfeeding).

What if I miss a pill?

If you missed an inert tablet, you may not worry and just throw it away since it does not contain any medication. If you missed an active tablet, you should take it within the next 12 hours. If the interval exceeds 36 hours, a contraceptive effect decreases. In this case, you need to continue taking birth control pills and additionally use other non-hormonal contraceptive methods (for example, a condom).

Precautions

Before taking birth control pills and every 6 months, a woman needs to undergo a general medical and gynecological examination (breast examination, liver function, blood pressure control and cholesterol concentration in the blood, urinalysis).

After childbirth or abortion (miscarriage), the drug can be used after the first normal menstrual cycle.

After the withdrawal of the drug, fertility is restored quickly, in1-3 menstrual cycles.

Small amounts of ethinyl estradiol and levonorgestrel are excreted in breast milk.

If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Diarrhea and vomiting can reduce the contraceptive effect of the drug.

Stop taking the tablets immediately if you have a migraine headache, pain and feelings of tightness in the chest, jaundice, visual impairment, cerebrovascular disorders, unusual pain or bloating of the veins on the legs, stitching pains when breathing or coughing, an increase in blood pressure. Besides, the drug should be canceled 3 months before the planned pregnancy and 6 weeks before the planned surgery.

Moderate irregular bleeding does not require discontinuation of the drug.

Smoking women taking Aubra for birth control have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and with the number of cigarettes smoked (especially over the age of 35).

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