Ashlyna is a 91-course of birth control. The main components are levonorgestrel and ethinyl estradiol able to prevent an unwanted pregnancy.
Indications for use
The main prescription of this drug is an oral contraception.
Mechanism of action
Ashlyna is a combined oral contraceptive which main contraceptive effect is an inhibition of gonadotropic hormone synthesis and suppression of ovulation. Additionally, by increasing the viscosity of cervical mucus, the movement of spermatozoa through the cervical canal slows down, and a change in the endometrium state blocks a fertilized egg implantation. The volume of menstruation and the frequency of its appearance are reduced.
Mode of application and dosage
Ashlyna is a 91-pills course. The dose hormone is steady in 84 pills containing levonorgestrel and ethinyl estradiol. The latest 7 pills contain a reduced dose of ethinyl estradiol during which application the menstruation comes. The pill should be taken at one and the same time daily.
- Hypersensitivity to the drug components;
- Lactating period;
- Severe liver disorders;
- Congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome);
- The presence or indication in the medical history of severe cardiovascular and cerebrovascular changes;
- Thromboembolism and predisposition to it;
- Liver tumors;
- Malignant tumors, especially breast cancer or endometrium;
- Family forms of hyperlipidemia;
- Severe forms of arterial hypertension;
- Severe diabetes and other endocrine gland diseases;
- Sickle cell anemia;
- Chronic hemolytic anemia;
- Hydatiform mole;
- Age over 40 years;
- Vaginal bleeding of unknown etiology;
- Idiopathic jaundice of pregnant women in the medical history;
- Severe pruritus of pregnant women;
- Herpes of pregnant women.
- Hepatic and gallbladder dysfunctions;
- Ulcerative colitis;
- Uterine myoma;
- Renal dysfunction;
- Adolescence (without regular ovulatory cycles).
In the presence of diabetes, cardiovascular diseases, arterial hypertension, kidney dysfunction, varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, small chorea, intermittent porphyria, latent tetany, bronchial asthma, the application of Ashlyna also requires caution.
Ashlyna is usually well-tolerated.
Possible transient side effects spontaneously occurring are: nausea, vomiting, headache, breast tenderness, weight and libido changes, mood swings, acyclic spotting, in some cases, eyelid edema, conjunctivitis, visual impairment, discomfort when wearing contact lenses. These negative reactions are temporary and disappear after discontinuation without any therapy.
In the case of the prolonged administration, the following side effects may be observed: chloasma, hearing loss, generalized pruritus, jaundice, calf muscle cramps, and increased frequency of epileptic seizures.
Rarely side effects of Ashlyna are hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure (BP), thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, vaginal candidiasis, increased fatigue, and diarrhea.
- The enhancement of metabolic properties of steroid hormones is possible in the case of the simultaneous application with barbiturates, some anti-epileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives.
- Reduction of contraceptive effectiveness can be manifested with the simultaneous application with some antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with changes in intestinal microflora.
- It is possible to further determine the prothrombin index and alter the anticoagulant
dose when using anticoagulants, coumarin or indanedione derivatives.
- In the case of the use of tricyclic antidepressants, maprotiline, beta-blockers, it is possible to increase their bioavailability and toxicity.
- It may be necessary to alter the dose of the birth control when applying oral hypoglycemic drugs and insulin.
- When combined with bromocriptine, the effectiveness of bromocriptine is decreased.
- When combined with drugs with a potential hepatotoxic effect, eg with dantrolene, there is an increase in hepatotoxicity, especially in women over 35 years of age.
What if I miss a dose?
The missed pill of Ashlyna should be taken within the next 12 hours. If 36 hours have passed since the last pill application, the contraception effect is reduced. Taking the drug should be continued from the package that has already been started to avoid intermenstrual bleeding with the exception of the skipped pill (s). It is recommended to use other additional non-hormonal methods of birth control (eg, barrier) in the cases of missing tablets.
Ashlyna and pregnancy
Taking Ashlyna birth control is contraindicated during pregnancy and lactation.