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Simpesse Review


Simpesse is an extended-cycle contraceptive which contains ethinyl estradiol and levonorgestrel, that are used to prevent pregnancy.

Contents:

Indications for use

  • Contraception.

Mechanism of action

The active substances in the composition of Simpesse suppress ovulation and change the viscosity of the secretion of the cervix, as a result of which it becomes impenetrable for spermatozoa.

Dosage and mode of application

Each pack contains 84 active tablets (with hormones) and 7 inert tablets (without hormones). Take 1 tablet daily, at the same time of a day and in the order indicated on the blister. Continue taking the drug for 91 days in a row.

Important: the contraceptive should be taken at intervals not exceeding 24 hours.

Begin a new package without interruption. The scheme of admission will be the same.

Side effects

Simpesse tablets can cause the following side effects:

  • nausea, vomiting;
  • headache;
  • breast engorgement;
  • weight gain;
  • decreased libido and mood;
  • coarsening of the voice;
  • intermenstrual spotting;
  • eyelid edema, conjunctivitis, visual impairment, discomfort when wearing contact lenses.

These phenomena are temporary and do not require any treatment).

With long-term use, the contraceptive can cause:

  • chloasma;
  • hearing loss;
  • generalized pruritus;
  • jaundice;
  • calf muscle cramps;
  • increased frequency of epileptic seizures;
  • hypertriglyceridemia;
  • hyperglycemia;
  • decreased glucose tolerance;
  • increased blood pressure;
  • thrombosis and venous thromboembolism;
  • skin rashes;
  • a change in the nature of vaginal secretion;
  • vaginal candidiasis;
  • increased fatigue;
  • diarrhea.

These reactions occur very rarely and require a doctor’s consultation.

Contraindications

Do not use Simpesse for birth control if you have any of the following conditions:

  • venous or arterial thrombosis and thromboembolism (including in the anamnesis), cerebrovascular disorders.
  • conditions preceding thrombosis (including in the anamnesis);
  • risk factors for venous or arterial thrombosis;
  • migraine with focal neurologic symptoms (including in the anamnesis);
  • diabetes mellitus with vascular complications;
  • pancreatitis with severe hypertriglyceridemia (including in the anamnesis);
  • hepatic insufficiency and severe liver disease;
  • benign or malignant liver tumors (including in the anamnesis);
  • hormone-dependent malignant diseases (including genital organs or mammary glands);
  • spotting of unknown origin;
  • pregnancy;
  • lactation period;
  • hypersensitivity to ethinyl estradiol and levonorgestrel or another component of the drug;
  • lactose / fructose intolerance, lactase / sucrose / isomaltase deficiency, glucose-galactose malabsorption.

With caution:

  • smoking;
  • thrombosis;
  • myocardial infarction;
  • obesity;
  • dyslipoproteinemia;
  • arterial hypertension;
  • migraine without focal neurological symptoms;
  • heart valve diseases;
  • heart rhythm disturbance;
  • prolonged immobilization;
  • extensive surgical interventions;
  • extensive trauma;
  • diabetes mellitus without vascular complications;
  • systemic lupus erythematosus;
  • hemolytic-uremic syndrome;
  • Crohn’s disease and ulcerative colitis;
  • sickle-cell anemia;
  • phlebitis of superficial veins;
  • hypertriglyceridemia;
  • liver diseases of mild and moderate severity;
  • jaundice;
  • cholestasis;
  • gallbladder disease;
  • otosclerosis with hearing impairment;
  • porphyria;
  • herpes during pregnancy;
  • Sydenham’s chorea;
  • angioedema (in women with hereditary forms of angioedema).

Interactions

The effect of Simpesse tablets may decrease when the contraceptive is combined with rifampicin, phenytoin, carbamazepine, butadiene, phenacetin, meprobamate, chlordiazepoxide, ketoconazole, broad-spectrum antibiotics, laxatives.

Metronidazole and ascorbic acid may increase the systemic effects of hormonal contraceptive components.

The contraceptive can weaken the effect of anticoagulants, hypotensive and hypoglycemic drugs, lorazepam and tazepam, tricyclic antidepressants, thyroxine, clofibrate.

Pregnancy and breastfeeding

Simpesse is contraindicated during pregnancy and lactation. If pregnancy is revealed during the use of birth control pills, they should be immediately discontinued.

What if I miss a pill?

If you miss an active tablet (day 1-84), you should take it within the next 12 hours. Otherwise, you should continue taking the tablets at a certain time of the next day, without taking the missed pill. Missing an active tablet increases the likelihood of spotting.

If you missed an inert tablet (day 85-91), discard it. The contraceptive effect remains reliable.

Precautions

Before using birth control pills, it’s recommended to undergo general medical and gynecological examination to exclude the presence of contraindications and pregnancy.

Women who have had a family history of bleeding disorders or thromboembolic disease at a young age should not use Simpesse.

AS long as you use the drug, you need to visit a gynecologist at least every 6 months.

The use of the medication is allowed no earlier than 6 months after the previous viral hepatitis (when the hepatic functions become normal).

If you need no menstrual bleeding after withdrawal of the drug, continued use is not allowed until you exclude pregnancy.

During the first 2-3 cycles, spontaneous intermenstrual bleeding may occur. In this case, you should continue taking the tablets. If intermenstrual bleeding does not disappear, or recur, or occur after a longer period of use, you should undergo a medical examination to determine the cause.

If you had vomiting or diarrhea within 1-4 hours after taking the drug, it is recommended to use an additional method of contraception (for example, a condom).

Women taking birth control pills have an increased risk of developing thromboembolism. This risk increases with age, mainly among women who smoke. Therefore, women over 35 who take Simpesse are not recommended to smoke.

If you plan a pregnancy, it is recommended to stop taking the contraceptive 3 months before the planned time of conception.

Stop using the drug immediately if you notice the following reactions:

  • increased or intensified migraine-like headaches;
  • acute worsening of visual acuity;
  • suspicion of thrombosis or infarction;
  • a sharp increase in blood pressure;
  • jaundice or hepatitis;
  • itching throughout the body.

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