Daysee is an extended-cycle contraceptive which contains ethinyl estradiol and levonorgestrel that are used to prevent ovulation.
Daysee contains a combination of estrogen and progestogen at low concentrations. The therapeutic effect is realized through three levels of influence.
- The first level is central, implying an influence on the hypothalamic-pituitary system with the oppression of hormone secretion, which is involved in the process of preparation and implementation of ovulation in the body;
- The second level is endometrial, which implies the influence of hormones on the endometrium with a change in its functional properties, which makes it impossible to implant even a fertilized egg;
- The third level is cervical. In the cervical canal, mucus thickening is observed under the hormonal action of the active components. Spermatozoa cannot penetrate the barrier from too much secret, and fertilization becomes impossible.
In addition to contraceptive effect, the drug normalizes the menstrual cycle, reduces the intensity of bleeding and soreness.
The 91-day Daysee pack contains 91 pills: 84 active pills with hormones and 7 “reminder” pills. You must take the pills in the order indicated on the blister: 1 pill per day at the same time, without interruption. Your period should begin while you are taking reminder pills. Begin a new pack without interruption.
Daysee tablets can cause the following side effects:
- tenderness and tension of the mammary glands,
- enlargement of the mammary glands,
- discharge from the mammary glands;
- change in libido;
- decreased mood;
- poor tolerance of contact lenses;
- other gastrointestinal disorders;
- changes in vaginal secretion;
- various skin disorders);
- fluid retention;
- change in body weight;
- hypersensitivity reaction.
Some women may experience chloasma, especially those with a history of chloasma during the previous pregnancy.
No serious side effects were reported with an overdose of Daysee. Symptoms may include nausea, vomiting, unexpected vaginal bleeding. There is no specific antidote for ethinyl estradiol and levonorgestrel. Treatment should be symptomatic.
Daysee pills are not used in the presence of any of the conditions or diseases listed below:
- venous thrombosis;
- myocardial infarction;
- cerebrovascular disorders;
- angina pectoris;
- severe liver diseases;
- arterial thrombosis;
- transient ischemic attacks;
- diabetes mellitus with concomitant vascular pathologies;
- heart rhythm disturbances;
- interference on the limbs;
- vaginal bleeding of unexplained genesis;
- uncontrolled arterial hypertension;
- hepatic insufficiency;
- liver tumors;
- pancreatitis with a marked increase in triglyceride levels;
- prolonged immobilization;
- hormone-dependent oncological pathologies;
- suspected hormone-dependent malignant neoplasms;
- extensive injuries;
- hypersensitivity to the components of the dragee;
- suspicion of pregnancy;
- serious surgical intervention.
- age over 35 years;
- a history of otosclerosis related to the previous pregnancy;
- idiopathic jaundice related to the previous pregnancy;
- thrombophlebitis of superficial veins;
- itching during pregnancy in anamnesis;
- Dubin-Johnson syndrome;
- sickle cell anemia;
- Rotor syndrome;
- thromboembolism when taking oral contraceptives in the anamnesis;
- hemolytic uremic syndrome;
- systemic lupus erythematosus;
- Gilbert’s syndrome;
- diabetes mellitus;
- Crohn’s disease;
- arterial hypertension.
- Barbiturates – reduced contraceptive effect;
- Isoniazid – increased risk of pregnancy due to a decreased contraceptive effect of Daysee;
- Carbamazepine – reduced contraceptive effect;
- Phenytoin – reduced contraceptive effect;
- Rifampicin – reduced contraceptive effect;
- Nevirapine – accelerated excretion of levonorgestrel;
- Phenylbutazone – increased risk of pregnancy due to decreased contraceptive effect;
- Cyclosporine – increased plasma concentrations of cyclosporine;
- Sulfanilamides – increased metabolism of active components of the contraceptive (ethinyl estradiol and levonorgestrel);
- Microinone – reduced contraceptive effect;
- Hypoglycemic agents – correction of a dose of hypoglycemic agents is necessary since Daysee can unpredictably influence the level of sugar;
- Indirect anticoagulants – a possible influence of birth control pills on coagulability. The dosages of indirect coagulants should be adjusted.
The drug is contraindicated for use during pregnancy and breastfeeding.
If pregnancy is detected during the use of the Daysee, the contraceptive should be immediately discontinued.
Combined contraceptives can change the composition of breast milk and reduce its quantity. A small amount of metabolites is excreted in milk, but there is no evidence of their negative impact on the growth and development of the child.
Missing a pill increases the risk of becoming pregnant.
- If you miss 1 active pill, take 2 pills the next day. Take the next pills in the usual order;
- If you miss 2 active pills in a row, take 2 pills per day for 2 subsequent days. Take the next pills in the usual order. Use additional barrier contraceptive means for the next 7 days;
- If you miss 3 active pills in a row, discard them and continue taking 1 pill per day in the usual order. You may have spotting. Use additional barrier contraceptive means for the next 7 days;
- If you miss any reminder pills, discard them and continue taking 1 pill per day until the pack is empty. You do not need to use additional barrier contraceptive means if you miss a reminder pill. If your menstrual period does not start while you are taking the reminder pills, you need to exclude pregnancy.
Smoking women who take Daysee contraceptive are at greater risk of developing cardiovascular disease than non-smokers;
After the withdrawal of the drug, fertility is restored after 1-3 menstrual cycles;
After delivery or an abortion, birth control pills can be taken only after the first menstrual cycle.
You can use the drug according to this scheme as long as you want to prevent pregnancy.
It is recommended to stop taking birth control pills 3 months before the planned pregnancy and switch to another non-hormonal method of contraception. If you are planning an extensive surgery, you need to stop taking tablets 6 weeks before the operation.
The effectiveness of Daysee decreases with vomiting and diarrhea.
It is necessary to consult a doctor if you have the following signs: edema, unilateral pain in the leg, sudden severe chest pain; cough attacks, shortness of breath, any unusual long-lasting headache, diplopia, partial or complete loss of vision, dizziness, slurred speech or aphasia, loss of consciousness, motor disorders, weakness or significant loss of sensitivity, apnea.
The likelihood of thrombosis and thromboembolism increases in smokers, with age, in women with dyslipoproteinemia, migraine, heart valve diseases, hypertension, atrial fibrillation, obesity, with prolonged immobilization and after major surgical interventions. Also, the risk increases if there is a family history of venous or arterial thromboembolism.
With a hereditary predisposition to venous or arterial thromboembolism, a woman should undergo a medical examination before taking oral contraceptives.
In the postpartum period, a woman has an increased risk of thromboembolism.
Women with diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel diseases (granulomatous enteritis or ulcerative colitis) and sickle cell anemia, can experience circulatory disorders.
There is data about an increased risk of cervical cancer with prolonged use of the drug. When using combined oral contraceptives, the risk of developing breast cancer is slightly increased. In rare cases, the development of liver tumors was reported. If you experience augmentation of the liver, severe pain in the abdominal region or symptoms of intra-abdominal hemorrhage, it is necessary to consult a doctor.
With a stable increase in blood pressure, it is necessary to cancel the contraceptive and begin therapy of hypertension.
Women with a tendency to chloasma should avoid exposure to ultraviolet radiation and prolonged exposure to the sun.
The use of Daysee tablets can influence the results of individual laboratory tests, including thyroid function, renal function, adrenal gland, liver function, carbohydrate metabolism, transport protein level in plasma and fibrinolysis and coagulation parameters.
The drug may cause irregular bleeding, especially during the first months. Therefore, any irregular bleeding should be assessed only after a period of adaptation (3 cycles). If you have a prolonged irregular cycle, you need to exclude pregnancy or malignant neoplasms.
During a break in taking active tablets, bleeding cancellation may not develop. If the drug was taken according to the recommendations, the risk of pregnancy is minimal.
Before taking the drug, it is recommended to undergo a thorough medical examination (general medical and gynecological). Repeated examinations are required every six months.
The drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.