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Amethyst Review

Amethyst (ethinyl estradiol/levonorgestrel) is a combination hormonal medication which is used for birth control.


Indications for use

  • Contraception.

Mechanism of action

Ethinyl estradiol and levonorgestrel suppress ovulation, cause an increase in the viscosity of the secretion of the cervix, which prevents spermatozoa from penetrating into the uterine cavity, and changes in the endometrium that prevent the implantation of a fertilized egg.

Dosage and mode of application

Take 1 tablet per day for 28 days in a row at the same time and in the order indicated on the blister.

To achieve the best contraceptive effect, the drug should be taken in accordance with the recommendations and at intervals not exceeding 24 hours.

The initial use starts on the 1st day of the menstrual period, starting with active tablets each containing levonorgestrel and ethinylestradiol. Then take inert pills. During this period, menstrual bleeding occurs.

Begin a new package regardless of whether menstruation has stopped or still continues. Each next Amethyst period begins on the same day of the week without interruption.

The contraceptive can be used as long as a pregnancy prevention is needed.


Cases of overdose were not recorded.

Theoretically, with an overdose, you may have the following symptoms:

  • nausea;
  • vomiting;
  • tension of mammary glands;
  • vaginal bleeding.

In this case, it is necessary to wash the stomach, take sorbents, monitor the patient’s condition, and, if necessary, carry out a complex of standard maintenance symptomatic therapy.

Side effects

Amethyst for birth control may cause the following adverse reactions:

  • increased blood glucose levels, anemia, changes in body weight, hyperbilirubinemia;
  • headache, migraine, memory loss, confusion, dizziness, insomnia;
  • visual impairment;
  • nausea, vomiting, bloating, abdominal pains, constipation, dyspeptic symptoms, pancreatitis, jaundice, diabetes mellitus;
  • acne, seborrhea, itching;
  • arterial hypertension, tachycardia, varicose veins, hemorrhoids;
  • thrombosis, superficial thrombophlebitis, arterial hypotension;
  • allergies, weight gain;
  • cholangitis, cholecystitis, liver function disorders;
  • neoplasia of the mammary glands, pain in the mammary glands;
  • anxiety, depression;
  • venous thromboembolism.

If you have any side effects, consult your doctor.


Do not use this birth control method if you have an increased sensitivity (allergy) to one of the components of the drug.

In addition, the use of Amethyst tablets is contraindicated in the following conditions:

  • breast cancer;
  • estrogen-dependent cancers;
  • vaginal bleeding of unexplained etiology;
  • incurable hyperplasia of the endometrium;
  • venous thromboembolism;
  • arterial thromboembolic disorders (angina pectoris, myocardial infarction);
  • thrombophilia (deficiency of protein C, S or antithrombin);
  • high risk of venous or arterial thrombosis;
  • liver tumors of any etiology;
  • liver disease;
  • porphyria;
  • severe hypertriglyceridemia.


  • Some antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines) can reduce the contraceptive effect of ethinyl estradiol/levonorgestrel;
  • When taking this contraceptive, you may need to adjust the dosage regimen for hypoglycemic drugs and indirect anticoagulants;
  • Some drugs may reduce the effectiveness of the contraceptive: antiepileptic drugs (primidone, phenytoin, barbiturates, carbamazepine, oxcarbazepine, topiramate, felbamate), antituberculosis drugs (rifampicin, rifabutin), drugs for HIV infection (ritonavir, nevirapine); medicines based on St. John’s wort.

Pregnancy and breastfeeding

Amethyst is contraindicated in pregnancy and during breastfeeding.

If pregnancy is detected during the use of birth control pills, the contraception should be immediately canceled.

What if I miss a pill?

If you miss a pill, you should take it within the next 12 hours. Otherwise, you should continue taking the pills at a certain time of the next day, without taking the missed pill. If you missed a tablet, the likelihood of spotting an pregnancy increases.


The drug is used with caution: varicose veins, epilepsy, hypertension, depression, myoma of the uterus, mastopathy, women over 40 years of age, smoking women.

With a therapeutic and prophylactic purpose, it is advisable to use monophasic drugs.

After discontinuation of the contraception, fertility is restored within 1-3 menstrual period.

The use after childbirth or abortion (miscarriage) is recommended with the first normal menstrual period.

Before starting contraception and every 6 months, a general medical and gynecological examination is recommended.

Smoking women over 35 who take Amethyst tablets have an increased risk of developing vascular diseases. The risk increases with age and with the number of cigarettes smoked per day.

Diarrhea and vomiting reduce the contraceptive effect of the drug. If you had these gastrointestinal disorders 3-4 hours after taking the pill, use additional non-hormonal methods of contraception).

Stop using birth control pills in the following cases: the onset of pregnancy, regular migraines, unusual pain or bloating of the veins on the legs, visual impairment, cerebrovascular disorders, jaundice, pain when breathing or coughing, feelings of tightness in the chest, an increase in blood pressure, 3 months before the planned pregnancy and 6 weeks before the planned surgery.

Moderate spotting between periods does not require discontinuation of the preparation.

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