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Chateal Review


Chateal is a hormonal contraceptive which contains 2 female hormones, ethinyl estradiol and levonorgestrel, that are used to prevent pregnancy.

Contents:

Indications for use

  • Prevention of pregnancy in women;
  • Dysmenorrhea, functional ovarian cysts;
  • Fibroadenoma and fibrotic cysts of the breast;
  • Prevention of endometrial cancer and ovarian cancer.

Mechanism of action

Chateal belongs to the group of combined medicines containing hormones secreted by the sex glands, intended for systemic use, with a contraceptive effect.

The use of this drug causes a contraceptive effect due to the fact that ethinyl estradiol and levonorgestrel have several mechanisms that interfere with the fertilization of the egg.

The contraceptive inhibits the process of ovulation and thickens mucus secreted in the cervical canal of the cervix.

Dosage and mode of application

Each Chateal pack contains 21active tablets and 7 inert tablets. Inert tablets are designed to ensure continuity of the drug. They contain no hormones.

Directions for use:

  • With the first use of the drug, the reception begins on the first Monday after the onset of menstruation;
  • if the menstruation started on Monday, the first pill is taken the same day;
  • bleeding “withdrawal syndrome” usually occurs within three days after stopping the reception of active tablets and may continue until the start of the new package;
  • during the first cycle of admission, you can rely on the contraceptive reliability of the drug only after 7 days of continuous intake of active tablets. Use additional non-hormonal (barrier) methods of contraception for the first 7 days;
  • the next 28-day course (and all subsequent courses)m should be started on the same day of the week, according to the following scheme: 21 days of taking active tablets and 7 days of taking inert tablets.

Mode of application:

  • Take 1 tablet daily at the same time, preferably during dinner or at bedtime;
  • Do not stop taking the drug, even if you have spotting or nausea;
  • Do not miss tablets even with infrequent sexual activity.

Dosing regimen:

Take 1 tablet for 28 days in a row.

Side effects

Chateal tablets can cause the following side effects:

  • nausea, vomiting, diarrhea;
  • increased fatigue, headache;
  • breast tension;
  • change in body weight and libido;
  • depressed mood;
  • chloasma;
  • intermenstrual bleeding;
  • complaints when wearing contact lenses;
  • increased triglycerides, glucose in the blood, reduced glucose tolerance;
  • high blood pressure;
  • pulmonary embolism, thromboembolism, myocardial infarction, stroke, retinal thrombosis, mesenteric thrombosis, pelvic floor thrombosis, lower extremities, deep vein thrombophlebitis of the lower extremities, deep vein thrombophlebitis;
  • hepatitis, gallbladder disease, jaundice;
  • skin rash, hair loss;
  • change of vaginal secretion, candidiasis.

Contraindications

Chateal contraceptive is not used in women with the following conditions:

  • hypersensitivity to ethinyl estradiol and levonorgestrel or another component of the drug;
  • thrombophlebitis, including deep vein thrombophlebitis, and thromboembolic events in the anamnesis;
  • diseases of the cerebral vessels or coronary arteries (present or in the anamnesis);
  • valvular heart disease with thrombogenic complications;
  • arterial hypertension without proper treatment;
  • diabetes mellitus with microangiopathies;
  • headaches with focal neurological symptoms;
  • post-surgical conditions requiring prolonged immobilization;
  • breast cancer (present or in an anamnesis);
  • endometrial cancer or other existing or suspected estrogen-dependent neoplasms;
  • pathological vaginal bleeding of unclear etiology;
  • cholestatic jaundice of pregnant women or jaundice developing after taking the drug;
  • adenoma or liver cancer, as well as an acute liver disease;
  • pregnancy or suspected pregnancy;
  • hemochromatosis or hemosiderosis;
  • children and adolescents under 18 years.

Interactions

Interactions between Chateal and other medications can lead to serious bleeding and/or inefficiency of the oral contraceptive.

  • Metabolism in the liver: interaction can be observed with drugs that induce microsomal enzymes, which leads to an increased clearance of sex hormones (hydantoin, barbiturates, primidone, carbamazepine, rifampicin, rifabutin, oxcarbazepine, topiramate, felbamate, ritonavir, griseofulvin and preparations containing St. John’s wort). The maximum induction of enzymes can last at least 4 weeks after the discontinuation of therapy;
  • The reduction of the contraceptive effect was reported with simultaneous use with antibiotics, such as ampicillin and tetracycline. The mechanism of this effect is unknown. Women who take any of these medicines need to temporarily use the barrier method in addition to Chateal or another method of contraception. When using drugs that stimulate microsomal enzymes, the barrier method should be used as an addition to Chateal during the whole period of the use of the contraceptive and within 28 days after the cancellation. Women who take antibiotics (except for rifampicin and griseofulvin) should use the barrier method during the use of birth control pills and within 7 days after withdrawal;
  • Oral contraceptives can affect the metabolism of other medications. Accordingly, the concentrations of such drugs in plasma and in tissues may increase (cyclosporine) or decrease (lamotrigine).

Pregnancy and breastfeeding

The drug is not used in pregnant women.

If there is a need to take Chateal for birth control, lactation (breastfeeding) should be suspended for the duration of treatment.

What if I miss a pill?

If you missed 1 active tablet:

  • Take the tablet as soon as you remember. The next tablet is taken at the usual time. This means that you can take two tablets in one day;
  • You do not need to use the barrier method of contraception during sex.

If you missed 2 active tablets in a row during the first or second week:

  • Take 2 tablets as soon as you remember and 2 tablets – the next day;
  • Then take 1 tablet a day before the end of the current package;
  • You can get pregnant if you have sex in the period of 7 days after missing tablets. It is necessary to use the barrier method of contraception (condoms and / or spermicides) during these 7 days.

If you missed 2 active tablets in a row during the third week:

  • Do not take the missed tablets and do not complete the current packaging;
  • Wait another 5 days. This will be 1 week without taking any pills;
  • Then, on the 8th day, start taking a new package, even if you still have menstruation;
  • During the 7-day period without tablets and during the first 7 days of taking the tablets from the new package, use an additional barrier method of contraception.

If you missed 3 or more active tablets (during the first 3 weeks):

  • Do not take the missed tablets, and do not complete the current packaging;
  • Wait another 4 days. This will be 1 week without taking the pills;
  • Then, on the 8th day, start taking a new package, even if you still have menstruation;
  • During the 7-day period without tablets and during the first 7 days of taking the tablets from the new package, use an additional barrier method of contraception.

If you missed any of the 7 inert tablets during the 4th week:

  • Discard the missed tablets;
  • Continue taking 1 tablet daily until the packaging is empty;
  • You will not need an additional barrier method of contraception if you start taking a new package on time.

If you missed any tablet from the package, and the expected menstruation did not occur, visit a doctor. Do not take pills until you get permission from your doctor.

Precautions

Before starting the course of taking Chateal tablets, you need to undergo a general medical and gynecological examination. It is necessary to measure blood pressure, conduct a laboratory examination of urine for glucose, monitor liver function, examine the mammary glands and perform a cytological analysis of the vaginal smear to exclude pregnancy.

Take this drug with caution in the following conditions: diabetes mellitus, heart disease is not ischemic etiology, hypertension, renal dysfunction, varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, small chorea, intermittent porphyria, latent tetany, asthma, benign uterine tumor, endometriosis or mastopathy.

During the treatment, you need to undergo a medical examination approximately every 6 months.

Oral hormonal contraceptives can be used 6 months after the previous viral hepatitis.

If you have severe pain in the upper abdomen, an increase in the liver or the signs of intraperitoneal bleeding, you need to exclude a liver tumor. In this case, you must stop taking the drug.

Studies have shown that combined oral contraceptives protect women from ovarian and endometrial cancer.

Some studies have found an increase in the incidence of cervical cancer among women who have been taking ethinyl estradiol and levonorgestrel contraceptives for a long time.

If you have no menstruation, pregnancy should be excluded.

If you have a liver disorder, you need to undergo medical supervision every 2-3 months.

When intermenstrual bleeding occurs, the drug should be continued, as in most cases these bleedings spontaneously cease. If intermenstrual bleeding does not disappear or recur, a medical examination should be performed to exclude genital mutilation.

If you have vomiting or diarrhea, the contraceptive should be continued. In addition, you need to use a non-hormonal method of contraception.

Women taking oral contraceptives containing estrogen can have an increased risk of developing thromboembolic diseases (stroke, myocardial infarction, subarachnoid hemorrhage).

The use of any combination oral contraceptive increases the risk of venous thromboembolic disease. The risk of these diseases reaches a maximum in the first year of taking medications.

The likelihood of thromboembolic disease when using oral contraceptives containing ethinylestradiol and levonorgestrel is 20 cases out of 100,000 women per year.

Some factors increase the risk of thromboembolic diseases: smoking, obesity, varicose veins, cardiovascular diseases, diabetes, migraine. Before using Chateal tablets in the presence of these factors, it is necessary to consult a doctor.

The risk of thromboembolic diseases associated with the use of combined oral contraceptives increases with age and is exacerbated with smoking. Therefore, women over the age of 35 are recommended to completely quit smoking.

Chateal should be discontinued immediately in the following cases:

  • a migraine-like or unusually severe headache, which has occurred or increased for the first time;
  • acute deterioration of visual acuity and loss of feelings;
  • suspicion of a thrombosis or a heart attack;
  • a sharp increase in blood pressure;
  • jaundice or hepatitis without jaundice;
  • generalized itching;
  • epilepsy or increased epileptic seizures;
  • before the planned operation (4 weeks before surgery);
  • prolonged immobilization (for example, after injuries)
  • pregnancy.

The drug does not affect the ability to drive a car or work with machines.

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