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Triphasil Review


Triphasil is a triphasic combination contraceptive containing 2 female hormones, ethinyl estradiol (estrogen) and levonorgestrel (progesterone), that are used to prevent pregnancy.

Contents:

Indications for use

  • Long-term oral contraception;
  • Treatment of dysmenorrhea, dysfunctional uterine bleeding, premenstrual syndrome, menstrual irregularities.

Triphasil is indicated for women with a balanced or moderately prevalent gestagenic phenotype. The drug can be prescribed to young women, women who have never given birth and middle-aged women.

Mechanism of action

Oral reception of a progestin with estrogen (female sex hormones, predominantly secreted at different phases of the period) in such proportions corresponds to physiological processes and provides high contraceptive efficacy and good tolerance of the drug.

Dosage and mode of application

Each Triphasil blister contains 28 tablets that have three different phases:

  • 6 brown tablets, each containing 0.050 mg of levonorgestrel and 0.030 mg of ethinyl estradiol;
  • 5 white tablets, each containing 0.075 mg levonorgestrel and 0.040 mg ethinyl estradiol;
  • 10 yellow tablets, each containing 0.125 mg levonorgestrel and 0.030 mg ethinyl estradiol;
  • 7 green tablets. These tablets do not contain hormones, they are designed to maintain continuity. They contain iron in a dose that is insufficient to treat iron deficiency anemia. Nevertheless, this dose of iron should be taken into account when taking other iron-containing drugs.

The drug should be taken orally, at the same time of the day, whenever possible in the evening. Tablets are swallowed whole, without chewing and washing down with a small amount of liquid.

For the purpose of contraception in the first period, take 1 tablet per day for 28 days, starting from the 1st day of the menstrual period. The next blister should be used without interruption.

The drug is taken as long as there is a need for contraception.

When switching from another oral contraceptive to Triphasil, a similar scheme is used.

After an abortion, it is recommended to start taking birth control pills on the same day or the day after the operation.

Overdose

  • Symptoms: nausea, uterine bleeding;
  • Treatment: when the first signs of an overdose occur in the first 2-3 hours, gastric lavage and symptomatic treatment are recommended. There is no antidote.

Contraindications

Triphasil contraceptive is contraindicated in the following cases:

hypersensitivity to any component of the drug, pregnancy, the period of breastfeeding, severe liver disease, liver tumors, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), cholelithiasis, cholecystitis, chronic colitis, presence or indication in the history of severe cardiovascular and cerebrovascular changes, thromboembolism and predisposition to it, phlebitis of deep veins of the lower extremities, hormone-dependent malignant neoplasms of genital organs and mammary glands, family forms of hyperlipidemia, arterial hypertension with systolic / diastolic arterial pressure 160/100 mm Hg. and above, surgical interventions, surgical operations on the lower extremities, prolonged immobilization, extensive injuries, pancreatitis (including in the anamnesis), accompanied by severe hypertriglyceridemia and hyperlipidemia, jaundice due to taking medications containing steroids, severe forms of diabetes mellitus, sickle cell anemia, chronic hemolytic anemia, vaginal bleeding of unknown etiology, migraine, bladder skeleton, otosclerosis, idiopathic jaundice of pregnant women, severe pruritus of pregnant women, herpes of pregnant women in anamnesis, smoking over the age of 35, age over 40, lactase insufficiency, lactose intolerance, glucose-galactose malabsorption.

With caution:

compensated diabetes mellitus without vascular complications, arterial hypertension with systolic / diastolic arterial pressure up to 160/100 mm Hg, varicose disease, multiple sclerosis, epilepsy, small chorea, porphyria, tetany, bronchial asthma, adolescence (without regular ovulatory periods), uterine myoma, mastopathy, depression, tuberculosis.

Side effects

Triphasil pills must be immediately discontinued if the following symptoms occur: nausea, vomiting, headache, breast engorgement, weight gain, decreased libido, depressed mood, chloasma, intermenstrual bleeding, eyelid edema, conjunctivitis, visual impairment, discomfort when wearing contact lenses (these phenomena are temporary and disappear after the drug withdrawal without prescribing any therapy).

In rare cases, a woman can experience triglycerides, blood glucose, decreased glucose tolerance, increased blood pressure, jaundice, hepatitis, liver adenoma, gallbladder disease (eg, cholelithiasis, cholecystitis), thrombosis and venous thromboembolism, skin rash, hair loss, increased secretions from vaginal discharge, vaginal candidiasis, increased fatigue, diarrhea.

With prolonged use, in rare cases, the following adverse reactions can occur: generalized itching, calf muscle cramps, hearing loss, increased frequency of epileptic seizures, and voice coarsening.

Interactions

  • ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines, dihydroergotamine, tranquilizers, phenylbutazone can weaken the contraceptive effect of Triphasil. In this case, it is recommended to use additional non-hormonal contraceptive methods;
  • anticoagulants, coumarin derivatives or indanedione (there may be a need for an early definition of a prothrombin index and a change in the dose of an anticoagulant);
  • tricyclic antidepressants, maprotiline, beta-blockers (bioavailability and toxicity may increase);
  • oral hypoglycemic drugs, insulin (you may need to change their doses);
  • bromocriptine (decreased efficacy);
  • drugs with possible hepatotoxic effect, especially dantrolene (risk of increased hepatotoxicity, especially in women over 35 years of age).

What if I miss a dose?

If you do not take an active pill (with hormones) on time, take the missed pill within the next 12 hours. If you do not take a pill within 36 hours, contraception cannot be considered reliable. However, in order to avoid intermenstrual bleeding, it is necessary to continue taking the tablets, minus the missing tablet (s). At this time it is recommended to use an additional non-hormonal method of contraception. If you miss a green inert tablet, you may not worry and just throw it away.

Triphasil and pregnancy

The intake of oral contraceptives, which preceded pregnancy, does not increase the risk of various fetal defects. Unintentional use of hormonal contraceptives in the early stages of pregnancy does not have a teratogenic or mutagenic effect and does not affect the health of the fetus. At the same time, this drug is classified in category X according to the risk in pregnancy. The possible risk associated with taking hormonal contraceptives, in this case, is much greater than the benefit. If you become pregnant, hormonal birth control pills should be discontinued.

Combined oral contraceptives inhibit lactation, so Triphasil is contraindicated during a breastfeeding period. A small amount of active substances (ethinyl estradiol, levonorgestrel) can be excreted in breast milk.

Special instructions

Triphasil should be discontinued 6 weeks before the planned surgical procedures.

The risk of thrombosis increases if you have a high blood pressure.

Gastrointestinal disorders:

Vomiting or diarrhea can lead to the withdrawal of ethinyl estradiol and levonorgestrel from the body, so in those cases where these symptoms occur within 1 day, one more pill must be taken. If these symptoms persist for a longer time, you should temporarily use other methods of preventing pregnancy.

Effect of the drug on the ability to drive a car and operate mechanisms:

The drug does not affect the ability to drive a vehicle and work with other mechanisms.

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