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Aviane Review


Aviane is a combination of female hormones (levonorgestrel and ethinyl estradiol) used to prevent unwanted pregnancy.

Contents:

Indications for use

  • Oral contraception,
  • functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia, premenstrual syndrome).

Mechanism of action

Aviane has a progestagenic and anti-estrogenic activity, due to which the process of ovulation is inhibited, and pregnancy does not occur. Preparations with levonorgestrel and ethinyl estradiol make cervical mucus more viscous, which makes it difficult for the sperm to enter the uterus. In addition, they affect the growth of the endometrium, slowing it, so even if the fertilization of the egg occurs, it will not be able to gain a foothold in the uterus because of the small thickness of the inner mucosa. Regular intake of the contraceptive slows the production of luteinizing and follicle-stimulating hormones, lowers the function of the yellow body.

Dosage and mode of application

Take Aviane exactly as prescribed by your doctor. Do not take more or less or more than recommended.

Follow the directions on the blister pack.

You will receive the first tablet on the first day of your period or on the first Sunday after the start of the period. You may need to use additional birth control, such as condoms or spermicide when you first start using Aviane.

Take one tablet daily at the same time of the day. When the tablets are over, start a new package the next day. You can get pregnant if you miss one tablet.

Aviane 28-day birth control pack contains 21 active pills with hormones and 7 “reminders” to keep you on a regular basis. Your period usually starts when you use these reminders.

You may have a breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very painful/abundant.

Use additional birth control if you have a severe vomiting or diarrhea.

When taking Aviane pills, you need to visit your doctor regularly.

Contraindications

Aviane is contraindicated in the following conditions:

  • hypersensitivity to the components of the drug (ethinyl estradiol or levonorgestrel);
  • pregnancy;
  • breastfeeding period;
  • severe liver disease;
  • congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome);
  • cholecystitis;
  • the presence or a history of severe cardiovascular and cerebrovascular changes;
  • thromboembolism and predisposition to it;
  • liver tumors;
  • malignant tumors, especially breast cancer or endometrium;
  • family forms of hyperlipidemia;
  • severe forms of arterial hypertension;
  • severe diabetes and other endocrine gland diseases;
  • sickle cell anemia;
  • chronic hemolytic anemia;
  • gallbladder;
  • age over 40;
  • vaginal bleeding of unknown etiology;
  • migraine;
  • otosclerosis;
  • idiopathic jaundice of pregnant women in anamnesis;
  • severe pruritus of pregnant women;
  • herpes.

Precautions

Take Aviane with caution if you have any of the conditions mentioned below:

  • diseases of the liver and gallbladder;
  • epilepsy;
  • depression;
  • ulcerative colitis;
  • uterine myoma;
  • mastopathy;
  • tuberculosis;
  • kidney disease;
  • adolescence (without regular ovulatory cycles);
  • diabetes;
  • cardiovascular diseases;
  • arterial hypertension;
  • renal dysfunction;
  • varicose veins;
  • phlebitis;
  • otosclerosis;
  • multiple sclerosis;
  • epilepsy;
  • small chorea;
  • intermittent porphyria;
  • latent tetany;
  • bronchial asthma.

Smoking increases the risk of serious cardiovascular side effects from the use of Aviane. This risk increases with age and the incidence of smoking (15 or more cigarettes per day) and is highly relevant in women over 35 years of age. Women using this oral contraceptive should be strongly advised not to smoke

Side effects

Aviane is usually well tolerated.

Possible side effects include nausea, vomiting, headache, breast engorgement, weight and libido changes, mood changes, acyclic spotting, eyelid edema, conjunctivitis, visual impairment, discomfort when wearing contact lenses (these phenomena are temporary and disappear after withdrawal of the drug, without any therapy).

With prolonged use of the drug, you may experience the following side effects (rarely): chloasma, hearing loss, generalized pruritus, jaundice, calf muscle cramps, increased frequency of epileptic seizures, hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure, thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, vaginal candidiasis, increased fatigue, diarrhea.

The above-mentioned side effects may worsen with an overdose of the drug, so you should strictly adhere to the regimen and the number of tablets.

Interactions

  • Barbiturates, some anti-epileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives are able to enhance the metabolism of steroid hormones included in Aviane;
  • Use of some antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines) may reduce contraceptive effectiveness of the drug. This interaction associated with changes in microflora in the intestine;
  • The simultaneous use of hormonal contraceptives and tricyclic antidepressants, maprotiline, beta-blockers may increase the bioavailability and toxicity of the latter items;
  • When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose;
  • When Aviane is combined with bromocriptine, the effectiveness of bromocriptine is reduced;
  • When the birth control pills are combined with drugs with a potential hepatotoxic effect (dantrolene), there is an increase in hepatotoxicity, especially in women over 35 years of age.

What if I miss a dose?

  • If you missed an inert pill (with no medication), just throw it away and continue taking the pills on an average schedule;
  • If you missed an active pill of Aviane (with hormones), take the missed tablet within the next 12 hours. If 36 hours have passed since taking the last pill, contraception is unreliable. To avoid intermenstrual bleeding, continue taking the drug from the package that has already been started, with the exception of the missed tablet. If you have missed active tablets, it is recommended to use additional non-hormonal methods of contraception (eg, condoms).

Yasmin and pregnancy

Aviane is contraindicated during pregnancy and breastfeeding.

If the pregnancy is detected during the use of this contraceptive, the drug should be immediately canceled. Numerous epidemiological studies have not revealed an increased risk of developmental defects in children born to women who received Aviane before pregnancy, or the presence of teratogenic effects when the drug was used during early pregnancy.

The combination of levonorgestrel + ethinyl estradiol, like other COCs, can reduce the amount of breastmilk and change its composition, so the use of this combination is contraindicated until the end of breastfeeding. A small amount of sex hormones and/or their metabolites can penetrate into breast milk and influence the health of the child.

Special instructions

Before starting Aviane and, subsequently, every 6 months. it is recommended to have a general medical and gynecological examination, including cytological analysis of the smear from the cervix, assessment of the mammary glands condition, determination of blood glucose, cholesterol and other liver function parameters, blood pressure control, urinalysis).

The use of the drug by young women with a thromboembolic disease is not recommended.

The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, provided that hepatic functions are normalized.

When you have sharp pains in the upper abdominal areas, hepatomegaly and signs of intra-abdominal bleeding, this may be due to a liver tumor. If necessary, the drug should be discontinued.

If the hepatic function worsens during the reception of Aviane pills, the therapist’s consultation is necessary.

When acyclic (intermenstrual) bleeding occurs, taking the contraceptive should be continued, as in most cases, these bleedings spontaneously cease. If acyclic (intermenstrual) bleeding does not disappear or recur, a medical examination should be performed to exclude the organic pathology of the reproductive system.

In the case of vomiting or diarrhea, the drug should be continued with using additional, non-hormonal method of contraception.

Smoking women taking hormonal contraceptives have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and depending on the number of cigarettes smoked (especially in women older than 35 years).

Aviane should be discontinued in the following cases:

  • a migraine headache for the first time or augmentation, or the appearance of an unusually severe headache;
  • early signs of phlebitis or phlebothrombosis (unusual pain or swelling of the veins on the legs);
  • jaundice or hepatitis without jaundice;
  • cerebrovascular disorders;
  • stitching pains of unclear etiology during breathing or coughing, pain and tightness in the chest;
  • acute deterioration of visual acuity;
  • suspected thrombosis or heart attack;
  • a sharp increase in blood pressure;
  • generalized itching;
  • increased epileptic seizures;
  • 3 months before the planned pregnancy, approximately 6 weeks before the planned surgical intervention.
  • pregnancy.

The influence Aviane on the ability to manage a vehicle and other mechanisms:

The drug does not affect the ability to drive a vehicle or operate mechanisms associated with an increased risk of injury.

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