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Isibloom Review

Isibloom is an oral contraceptive containing desogestrel and ethinyl estradiol indicated for the prevention of pregnancy.


Indications for use

  • Oral contraception.

Mechanism of action

Isibloom is a combination oral contraceptive which inhibits the synthesis of gonadotropins and suppresses ovulation. In addition, the movement of spermatozoa through the cervical canal slows down, and a change in the state of the endometrium prevents the implantation of a fertilized egg. Ethinyl estradiol is a synthetic analogue of endogenous estradiol, desogestrel has a pronounced gestagenic and antiestrogenic action, similar to endogenous progesterone, weak androgenic and anabolic activity. The drug has a beneficial effect on lipid metabolism: it increases the concentration of high-density lipoprotein in the blood plasma without affecting the content of low-density lipoprotein. The drug reduces the amount of blood loss during menstrual bleeding (with initial menorrhagia), normalizes the menstrual period, has a beneficial effect on the skin (especially in acne vulgaris).

Dosage and mode of application

Isibloom contains 21 active pills each containing desogestrel and ethinyl estradiol and 7 inert pills (hormone-free).

Tablets are taken orally, from the first day of the period. Take 1 tablet a day for 28 days, if possible at the same time of day. After taking the last active tablet, you will l have a menstrual-like bleeding as a result of the withdrawal of the drug. Begin a new package without making a break (on the same day of the week). This pill regimen is followed as long as there is a need for contraception. When complying with the rules of admission, the contraceptive effect is maintained for 7 hormone-free days.


In the case of an overdose, you may experience nausea, vomiting, spotting. The drug does not have a specific antidote, treatment is symptomatic. If overdose symptoms occur in the first 2-3 hours after taking a tablet, gastric lavage may be indicated.

Side effects

If you have the following side effects after taking Isibloom, you should stop using the drug:

  • arterial hypertension;
  • hemolytic uremic syndrome;
  • porphyria;
  • loss of hearing due to otosclerosis.

Rare side effects:

arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism);
exacerbation of reactive systemic lupus erythematosus.

Very rare side effects:

arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins;
Chorea Sydenham (passing after the abolition of the drug).

Other side effects are less severe but more common. The feasibility of continuing hormonal contraception is decided individually by a doctor, based on the benefit/risk ratio:

  • Reproductive system: acyclic bleeding from the vagina, amenorrhea after withdrawal of the drug, a change in the state of vaginal mucus, inflammatory processes of the vagina (eg: candidiasis);
  • Mammary glands: tension, pain, enlargement of the mammary glands, galactorrhea;
  • Gastrointestinal and hepatobiliary system: nausea, vomiting, Crohn’s disease, ulcerative colitis, the occurrence or worsening of jaundice and / or itching associated with cholestasis, cholelithiasis;
  • Skin: nodular/exudative erythema, rash, chloasma;
  • Central nervous system: a headache, migraine, mood changes, depressive states;
  • Metabolic disorders: fluid retention in the body, change (increase) in body weight, decrease in tolerance to carbohydrates;
  • Eyes: increased sensitivity of the cornea when wearing contact lenses;
  • Other: allergic reactions.


Isibloom is contraindicated for use in the presence of the following conditions/diseases:

  • pregnancy or suspicion of it;
  • lactation;
  • severe and/or multiple risk factors for venous or arterial thrombosis (including moderate to severe arterial hypertension with a blood pressure of 160/100 mm Hg or more);
  • precursors of thrombosis (including transient ischemic attack, angina), including a history;
  • a migraine with focal neurologic symptoms, including a history;
  • venous or arterial thrombosis/thromboembolism (deep vein thrombosis of the tibia, pulmonary embolism, myocardial infarction, stroke), including a history, venous thromboembolism in relatives;
  • diabetes mellitus (with angiopathy);
  • pancreatitis (including in the anamnesis), accompanied by severe hypertriglyceridemia;
  • dyslipidemia;
  • severe liver disease,
  • cholestatic jaundice (including during pregnancy),
  • hepatitis, including a history;
  • jaundice due to the intake of LC containing steroids;
  • cholelithiasis, including a history;
  • Gilbert’s syndrome, Dubin-Johnson syndrome, Rotor syndrome;
  • liver tumors (including in the anamnesis);
  • severe itching, otosclerosis, or progression of otosclerosis during a previous pregnancy or while taking glucocorticosteroids;
  • hormone-dependent malignant neoplasms of the genital organs and mammary glands (including a suspicion of them);
  • vaginal bleeding of unknown etiology;
  • smoking over the age of 35 (more than 15 cigarettes per day);
  • individual hypersensitivity to desogestrel/ethinyl estradiol or other components of the drug.

With caution:

Conditions that increase the risk of venous or arterial thrombosis / thromboembolism: age over 35 years, smoking, a family history, obesity (body mass index more than 30 kg / m2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular heart disease, fibrillation auricles, prolonged immobilization, extensive surgery, surgery on the lower limbs, severe injury, varicose veins and superficial thrombophlebitis, the postpartum period, severe depression (including a history), changes in biochemical parameters (resistance of activated protein C, hyperhomocysteinemia, deficiency of antithrombin III, deficiency of protein C or S, antiphospholipid antibodies, including antibodies to cardiolipin, lupus anticoagulant); diabetes mellitus not complicated by vascular disorders, systemic lupus erythematosus, Crohn’s disease, ulcerative colitis, sickle cell anemia; hypertriglyceridemia (including a family history), acute and chronic liver disease.


  • Drugs that induce hepatic enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, and drugs containing St. John’s wort, reduce the effectiveness of oral contraceptives and increase the risk of bleeding. The maximum level of induction is usually achieved not earlier than 2-3 weeks but can last up to 4 weeks after the drug discontinuation;
  • Ampicillin, tetracycline may reduce efficacy (interaction mechanism is not established). With joint use, it is recommended to use an additional barrier method of contraception during the entire course of treatment and for 7 days (for rifampicin – 28 days) after discontinuation of the drug;
  • Oral contraceptives can reduce carbohydrate tolerance, increase the need for insulin or oral antidiabetic agents.

Pregnancy and breastfeeding

Use of Isibloom during pregnancy and breastfeeding is contraindicated.

What if I miss a pill?

If the delay in taking an active pill is no more than 12 hours, you should take the missed pill and then continue taking pills at the usual time. If the delay exceeds 12 hours, then contraceptive reliability in this period is not guaranteed and you need to use additional contraceptive methods.

When missing 1 tablet In the first or second week of the period, it is necessary to take 2 tablets the next day and then continue regular intake, using additional contraceptive methods until the end of the period. When skipping 1 tablet in the third week of the period, in addition to the measures listed, you should skip 7 inert tablets and start a new package.

Missing active pills increases the likelihood of ovulation and/or bleeding, so in such cases, it is recommended to use additional methods of contraception. If you missed any inert tablets, you may throw them away since they do not contain any medication.


When using Isibloom for birth control, medical supervision is required at least every 6 months. After suffering viral hepatitis, use of the drug is possible no earlier than after 6 months (with normalization of liver function).

In the case of vomiting or diarrhea, the use of a barrier method of contraception is required.

When using oral hormonal contraceptives, you should stop smoking (increased frequency of thromboembolism of different localization, especially in women over 35 years of age).

The drug (ethinyl estradiol/desogestrel) cannot be used by men.

Since the drug can be potentially dangerous for certain groups of patients, it is necessary to inform your doctor about pregnancy, breastfeeding, the presence of allergies and other diseases (see “Contraindications”), as well as the use of any other medicines, nutritional supplements and herbal medicines.

If you experience an allergic reaction or a hypersensitivity reaction, you should immediately seek medical attention.


This pill caused spotting, frequent mood changes, migraines, nausea, anxiety. I’m finishing the pack and calling my doctor
- Amilia: Haley

My experience with Isibloom is great. 5 months and no complaints. Periods are light and short. I also appreciate breasts increased by one size!))) No noticeable weight gain, no mood changes, no cramps. In general, a great experience!
- Mildred Mendieta

I’ve only been on this birth control for about 3 months and the only adverse reaction I have is cramping before periods. But my skin cleared up very noticeably. I will continue to use it.
- Doris Anderson

I’ve been taking Isibloom for 7 months now and the only side effect I’ve had has been hair loss. I don’t know why that is. No cramps, depression, acne, spotting, moods or something like this.
- Pamela Brooks

Isibloom gave me the worst nausea I've had in my life. Going to call my doctor and ask for something else. Everyone is different but this pill is not for me.
- Jennie Welch

I switched to this pill. The first week was fine, but then I started to suffer from major cramps and nausea. Next I had two weeks of continuous spotting. Had to quit it. Would not recommend.
- Ina Patterson

Isibloom was ok. My acne got better. However I felt a little dizzy during the first 2/3 months of taking it. It didn’t cause mood swings. So I’d recommend it as BC.
- Monique Sammons

Starting taking COCs 2 years ago for my own purpose, I was looking for a lot of different information on the Internet. I had found answers, not to all my questions. Indeed, someone is losing weight and cleaning the skin, while someone is generally claiming that COC is a kind of slow death. So, what side effects I found: decreased libido, acne on the cheekbones, which indicates something related to the genitourinary system, a temperature of 37.2 - 37.5, which lasts a year, a very strong weakness. At some moment, I stopped drinking pills, because something was going wrong with the body. Then I visited a doctor and it turned out this preparation is a contraindication for me.
- Lily

I took Isibloom for 6 years. In the first three years, I took breaks in admission for a couple of months annually (as I later found out that it was very harmful). I tool this drug without breaks for the next 2 years, during the same period health problems accidentally emerged that developed on the background on hormonal contraceptives. I took a break for a year to restore my body. Then I took it another year and finally decided to say goodbye to Isibloom and other COCs. These pills are harmful to health. But remember, the body is individual for every woman. Consult your gynecologist first.
- Isabella

I had stable periods all my life. I didn’t know acne or any other female problems. The cycle is stable lasting 28 days. After the second labor, the body could not recover, the periods were unstable, I suffered the wild pains (the painkillers were useless). I visited 3 different gynecologists and they all recommended Isibloom. No one asked for hormone tests. Improvements were as follows: stable periods, painless, hair began to look better and thicker, lost weight (a couple of kgs). Having taken this COC exactly for 9 months, in a couple of months my condition worsen. At first, I lost my hair, than acne on my temples, forehead, nose, chin, and then through the neck and back appear. Acne, both small and large subcutaneous pimples in large quantities. There were mood swings, terrible premenstrual syndrome, depression and all the signs of a lack of female sex hormones. I have been treated and is still recovering. I do not recommend taking this drug before you do not undergo a complete medical screening.
- Sophia

Actually, I have been taking Isibloom for almost 5 years. I chose this type of pills on the recommendation of my gynecologist. If you also plan to choose COCs as contraception, the consultation should be carried out. There are no painful critical days when I started taking Isibloom. My skin condition improved, although I had not complained about pimples before. The regular cycle is the biggest advantage of this drug. I stopped taking it for half a year already. To be honest, this is such a relief because taking them at the same time every day was terribly annoying. I came to this decision when my periods days were shortened (from 5 to 3). It became scary as if the body loses its important functions. It was difficult to withdraw it, both psychologically and physically. But still, the effect of this drug is confirmed
- Emily

Birth control pills Isibloom - is popular among gynecologists and women. I want to note right away that medications cannot be taken without prior consultation with your doctor. I started taking these birth control pills about 2.5 years ago on the recommendation of my gynecologist as the method of contraception. These were my first oral contraceptives. The efficiency is 100%, periods are less painful. The drug did not affect the condition of the hair. The face skin has become better.
- Paige

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