Cyred Review

Cyred is a monophasic contraceptive. It contans a low dose of two hormones: desogestrel and ethinyl estradiol. This birth control positively influence the cervical mucuus resulting in an ovulation suppression.



Indications for use

Oral contraception

Mechanism of action

Cyred is a combined oral contraceptive. Each tablet contains a small amount of 2 different female sex hormones – desogestrel (progestin) and ethinyl estradiol (estrogen). Because of small amounts of hormones, this birth control is referred to a low dose oral contraceptives. Since all the tablets in the pack contain the same amount of the same hormones, Cyred refers to monophasic combined oral contraceptives.

The drug also has an additional non-contraceptive pharmacological action:

  • on the background of its intake, menstruation becomes less abundant and painful;
  • women who take birth control pills are less likely to have anemia, some diseases of the uterus, ovaries, mammary glands;
  • has a beneficial effect on the skin, especially improving its condition with vulgar acne.
  • After discontinuation of the drug, the ability to conceive is quickly restored.


Mode of application and dosage

Cyred is prescribed as a 28-days course. The regimen includes the daily application of a birth control pill at one and the same time. During the latest 7 days, the preparation requires no 7-days break. The pill should be taken with a full glass of water. The menstruation comes when the latest 7 placebo pills are taken.


  • Thrombosis (venous or arterial) presently diagnosed or in the medical history inclusively of deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke;
  • Presently diagnosed or prior transferred thrombosis including ischemic disease or angina pectoris;
  • Diabetes mellitus complicated by vascular lesions;
  • Severe or multiple risk factors for venous or arterial thrombosis;
  • Severe liver diseases: diagnosed or suggested;
  • Hepatic tumors (benign and malignant): diagnosed or suggested;
  • Diagnosed or suspected hormone-dependent malignant tumor of genital organs or mammary glands;
  • Vaginal bleeding of unknown genesis;
  • Diagnosed or suggested pregnancy;
  • Lactation period;
  • Hypersensitivity to any of the drug components;
  • Migraine with focal neurological symptoms;
  • Hypertriglyceridemia.

If the drug is used if you have one of the following conditions, you may need to see a doctor regularly. Before you start taking the drug, tell your doctor about the following conditions/diseases:

  • smoking;
  • migraine;
  • epilepsy;
  • diabetes mellitus;
  • overweight;
  • high blood pressure;
  • heart valve disease or heart rhythm disturbances;
  • venous inflammation (superficial thrombophlebitis);
  • varicose veins;
  • thrombosis, myocardial infarction or stroke;
  • a higher cholesterol or triglyceride level;
  • breast cancer;
  • gallbladder disease;
  • Crohn’s disease or ulcerative colitis (chronic inflammatory bowel disease);
  • systemic lupus erythematosus;
  • a hemolytic uremic syndrome (a bleeding disorder that causes kidney failure);
  • sickle cell anemia;
  • chloasma (yellow-brown areas of skin pigmentation, mainly on the face).


Side effects

The following side effects were reported in persons taking Cyred. They may occur in the first few months of use and usually decrease with the time. They are:

  • headache;
  • gastralgia;
  • nausea;
  • vomiting;
  • tenderness of the mammary glands;
  • increase in body weight;
  • impaired glucose tolerance;
  • fluid retention;
  • changes in libido;
  • decreased mood;
  • eyelid edema;
  • skin rash;
  • nodal erythema;
  • conjunctivitis;
  • discomfort when wearing contact lenses;
  • thrombophlebitis;
  • thromboembolism (may be impaired perception: visual impairment, hearing loss);
  • generalized pruritus;
  • cholestatic jaundice;
  • cholelithiasis;
  • increased blood pressure;
  • intermenstrual bleeding;
  • a change in vaginal secretion;
  • development of candidiasis of the vagina.

With prolonged use (extremely rare) – chloasma, hepatocellular adenoma may be observed.


Interaction with certain drugs can lead to heavy bleeding and inefficiency of oral contraceptives. Such cases were observed with the use of hydantoins, barbiturates, primidone, carbamazepine, rifampicin, isoniazid; they are possible with the appointment of oxcarbazepine, topiramate, felbamate and griseofulvin. A decrease in the effectiveness of oral contraceptives was also observed with the administration of certain antibiotics, such as ampicillin, tetracycline, neomycin, penicillin, chloramphenicol, and also activated charcoal, laxatives.

This birth control drug reduces the effectiveness of oral anticoagulants, anxiolytics (diazepam), tricyclic antidepressants, theophylline, caffeine, hypoglycemic drugs, clofibrate, glucocorticosteroids.

Always tell the doctor who prescribes your birth control pills, what medications you are already using. If the doctor prescribes to you other medications, tell him that you are taking Cyred.

What if I miss a dose?

If you are late when taking another tablet for less than 12 hours, the effectiveness of the drug is preserved.

Take the missed pill as soon as you remember, and take the following tablets at the usual time.

If you are late with taking another tablet for more than 12 hours, the effectiveness of the drug may be reduced. The more pills you missed, the higher the risk of reducing contraceptive effectiveness.

The risk of pregnancy is especially high if you miss the pills at the beginning or at the end of the pack.

If there is more than one missed pill in the pack, please contact your doctor.

Cyred and pregnancy

The use of the drug is contraindicated during pregnancy and lactation.

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