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Simliya Review

Simliya is a hormonal birth control preparation intended for a pregnancy prevention. It contains two hormones suppressing an ovulation and egg maturation.



Indications for use

Simliya is intended for an oral hormonal contraception.

Mechanism of action

This birth control drug is a combined oral contraceptive. Its main contraceptive effect is a suppression of gonadotropin synthesis resulting in the prevention of an ovulation. Additionally, when magnifying the cervical mucus viscosity, the movement of spermatozoa through the cervical passage slows down. A change in the endometrium state prevents a fertilized egg attachment.

When using the drug, it is observed a significant decrease in the amount of menstruation (with the initial menorrhagia). Finally, the menstrual cycle is normalized, and a favorable effect on the skin is noted (especially with acne vulgaris).

Mode of application and dosage

Simliya is a 28-days course. The drug is prescribed for a daily intake – 1 tablet at one and the same time containing 2 hormones: desogestrel and ethinyl estradiol. There is no a 7-day break. You continue taking birth control pills. It contains ethinyl estradiol but in a lower dosage. When taking this almost placebo pills the menstruation comes.


  • Pregnancy;
  • Breastfeeding;
  • Presence of severe and/or multiple risk factors for venous or arterial thrombosis;
  • Predisposition to thrombosis (including transient ischemic attack, angina pectoris), including in the anamnesis;
  • Migraine with focal neurologic symptoms, including in the medical history;
  • Venous or arterial thrombosis/thromboembolism (including deep vein thrombosis of the lower leg, pulmonary embolism, myocardial infarction, stroke) at present or in the medical history;
  • Diagnosed venous thromboembolism in relatives;
  • Diabetes mellitus;
  • Pancreatitis (including in the medical history), accompanied by severe hypertriglyceridemia;
  • Dyslipidemia;
  • Severe hepatic dysfunction, cholestatic jaundice (including during pregnancy), hepatitis, incl. in the medical history;
  • Jaundice due to taking medical substances in which composition there are steroids;
  • Cholelithiasis at present or in the anamnesis;
  • Gilbert’s syndrome, Dubin-Johnson syndrome, Rotor’s syndrome;
  • Hepatic tumors (including in the medical history);
  • Severe itching, otosclerosis or progression of otosclerosis during a previous pregnancy or when taking glucocorticosteroids;
  • Hormone-dependent malignant neoplasms of genital organs and mammary glands;
  • Vaginal bleeding of unclear etiology;
  • Smoking over the age of 35 (more than 15 cigarettes a day);
  • Individual hypersensitivity to Simliya or its components.


Side effects

Side effects caused by Simliya, the appearance of which requires immediate discontinuation of the drug:

  • arterial hypertension;
  • haemolytic uremic syndrome;
  • porphyria;
  • loss of hearing due to otosclerosis.
  • Rare side effects: arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, thromboembolism of the pulmonary artery); exacerbation of reactive systemic lupus erythematosus.
  • Very rare side effects: arterial or venous hepatic, mesenteric, renal, retinal arteries and veins thromboembolism; Sydenham’s chorea. Other side effects are less severe, but more common. The expediency of continuing the use of the drug is decided individually after consultation with the doctor, based on the benefit/risk ratio.
  • Reproductive system: acyclic bleeding/spotting, amenorrhea after this drug withdrawal, change in the state of vaginal mucus, development of inflammatory vaginal processes (eg: candidiasis).
  • Mammary glands: tension, pain, the mammary glands’ enlargement, galactorrhea.
  • Gastrointestinal tract and hepato-biliary system: nausea, vomiting, Crohn’s disease, ulcerative colitis, the onset or exacerbation of jaundice and/or itching accompanied by cholestasis, cholelithiasis.
  • Skin condition: nodal/exudative erythema, rash, chloasma.
  • Central nervous system: headache, migraine, mood changes, depressive states.
  • Metabolic changes: fluid body retention, change (increase) in body weight, reduced tolerance to carbohydrates.
  • Eyes condition: increased sensitivity of the cornea when wearing contact lenses.
  • Other: allergic reactions.



Medications that force hepatic enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, drugs containing St. John’s Wort decrease the effectiveness of oral contraceptives and magnify the risk of breakthrough bleeding. The maximum level of effect is usually achieved no earlier than 2-3 weeks but can last up to 4 weeks after the drug withdrawal.

Ampicillin, tetracycline reduce the effectiveness of birth control drugs (the mechanism of interaction is not established).

If it is necessary to make a combination, it is recommended to use an additional barrier method of contraception throughout the course of treatment and for 7 days (for rifampicin – for 28 days) after drug discontinuation.

Oral contraceptives can decrease tolerance to carbohydrates, increase the need for insulin or oral antidiabetic drugs.

What if I miss a dose?

If the woman forgets to take the pill on time, and ша no more than 12 hours have passed, you just need to take a forgotten pill, and then continue the reception at the usual time. If more than 12 hours have passed between taking the tablets, contraceptive reliability is not guaranteed in this cycle, and additional methods of contraception are recommended.

If you miss one tablet on the first or second week of the cycle, you need to take 2 tablets the next day and then continue with regular reception, using additional contraceptive methods until the end of the cycle.

Simliya and pregnancy

The use of the drug during pregnancy and breastfeeding is contraindicated.

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