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Enskyce Review

Enskyce is a combination birth control pill containing 2 hormones: ethinyl estradiol and desogestrel, that are used to prevent pregnancy.


Indications for use

  • Contraception;
  • Treatment of menstrual disorders;
  • Acne treatment.

Mechanism of action

Enskyce protects a woman from unwanted pregnancy. This happens for the following reasons: under the influence of the medicine, the production of hormones responsible for reproduction (gonadotropins) is interrupted. This results in the blocking of the ovulation process. Slime, which is on the cervix, under the action of the drug changes its composition and becomes a serious obstacle, which prevents spermatozoa from penetrating into the uterus. In some cases (very rarely) ovulation still occurs, but this does not lead to fertilization of the egg, as it does not have the ability to firmly adhere to the walls of the uterus due to the thinning of the endometrium under the influence of the drug.

Also, the remedy regulates lipid metabolism in the blood, which prevent the development of atherosclerosis symptoms, and improves the condition of the skin.

Dosage and mode of application

Each Enskyce pack contains 28 pills: 21 active pills (0.03 mg of ethinyl estradiol and 0.15 mg of desogestrel) and 7 inert pills (no hormones).

The first tablet should take on the first day of the period. Take 1 pill at the same time of a day for 28 days in a row (skipping is not recommended, otherwise the effect of contraception may not work).

After you have used all active 21 tablets, take 7 inert tablets (“reminders”). During this period, bleeding should occur. Once you have taken the last pill from the blister, begin a new pack, regardless of the beginning and end of menstruation.

If you follow the directions given above, the drug will work from the first day. If the use of tablets started from the 2nd to the 5th day of the menstrual poriod, you will need to use additional contraception methods for a whole week. If you started taking Enskyce tablets on the fifth day of your period, the drug will not be effective.

If a woman is recommended by a doctor to use this contraceptive after abortion (scraping), she can start taking the pills on the same day. If a woman has recently given birth to a child, she can use this contraceptive 21 days after delivery. But this can be done only in cases where a young mother does not breast-feed the baby. If she begins to use the drug after the specified period, she will need to use additional contraception methods.

If you previously used another hormonal birth control drug containing 28 tablets, you can use Enskyce according to the instructions immediately after their termination. If the previous pack contained 21 tablets, the use of Enskyce begins exactly one week after the end of the course of the previous medication.

If a woman used drugs containing progesterone, it is recommended to take Enskyce on the first day of the menstrual period if you have a menstrual bleeding.

Side effects

In some cases, birth control pills can cause adverse reactions:

  • arterial hypertension, arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower limbs, thromboembolism of the pulmonary artery), venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins;
  • loss of hearing due to otosclerosis;
  • hemolytic-uremic syndrome, porphyria, exacerbation of reactive systemic lupus erythematosus, Sydenham’s chorea;
  • acyclic bleeding / spotting from the vagina, amenorrhea after drug withdrawal, change in the state of vaginal mucus, development of inflammatory processes of the vagina, candidiasis, stress, pain, enlargement of the mammary glands, galactorrhea;
  • nausea, vomiting, Crohn’s disease, ulcerative colitis, the onset or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis;
  • erythema nodosum, exudative erythema, rash, chloasma.
  • headache, migraine, mood lability, depression;
  • increased sensitivity of the cornea (when wearing contact lenses);
  • fluid retention in the body, change (increase) in body weight, reduced tolerance to carbohydrates;
  • allergic reactions.

If you have any of the mentioned side effects after taking Enskyce tablets, consult a doctor.


Enskyce contraceptive is contraindicated in the presence of any of the conditions mentioned below:

  • risk factors for venous or arterial thrombosis (including severe or moderate arterial hypertension with BP ≥ 160/100 mm Hg);
  • vaginal bleeding of unclear etiology;
  • smoking at the age of over 35 years (more than 15 cigarettes a day);
  • pregnancy;
  • breastfeeding period;
  • thrombosis (including in the anamnesis);
  • transient ischemic attack (including in the anamnesis);
  • angina pectoris (including in the anamnesis);
  • migraine with focal neurologic symptoms (including in the anamnesis);
  • severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis (including in the anamnesis);
  • cholelithiasis (including in the anamnesis);
  • Gilbert’s syndrome, Dubin-Johnson syndrome, Rotor syndrome;
  • liver tumors (including in the anamnesis);
  • severe itching, otosclerosis or its progression with a previous pregnancy;
  • venous or arterial thrombosis / thromboembolism (including in the anamnesis);
  • a venous thromboembolism in the anamnesis;
  • diabetes mellitus (with angiopathy);
  • pancreatitis (including in the anamnesis), accompanied by severe hypertriglyceridemia;
  • dyslipidemia;
  • hormone-dependent malignant neoplasms of genital organs and mammary glands;
  • hypersensitivity to the components of the drug (ethinyl estradiol and desogestrel).

With caution:

  • age over 35 years;
  • smoking;
  • surgical intervention on the lower extremities;
  • severe trauma;
  • varicose veins and superficial thrombophlebitis;
  • postpartum period;
  • severe depression (including in the anamnesis);
  • obesity;
  • dyslipoproteinemia;
  • arterial hypertension;
  • migraine;
  • epilepsy;
  • valvular heart disease;
  • atrial fibrillation;
  • prolonged immobilization;
  • extensive surgical intervention;
  • changes in biochemical parameters;
  • hyperhomocysteinemia;
  • deficiency of antithrombin III;
  • deficiency of protein C or S;
  • antiphospholipid antibodies, including antibodies to cardiolipin, including lupus anticoagulant);
  • diabetes mellitus not complicated by vascular disorders;
  • Crohn’s disease;
  • ulcerative colitis;
  • sickle-cell cell anemia;
  • hypertriglyceridemia (including in the anamnesis);
  • acute and chronic liver disease.


  • Drugs that induce hepatic enzymes (hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, St. John’s wort preparations) reduce the effectiveness of Enskyce pills and increase the risk of breakthrough bleeding. The maximum level of induction is usually achieved no earlier than 2-3 weeks but can last up to 4 weeks after drug withdrawal;
  • Ampicillin and tetracycline reduce the effectiveness of Enskyce (the mechanism of interaction is not established). If this combination cannot be avioded, it is recommended to use an additional barrier method of contraception throughout the course of treatment and for 7 days (for rifampicin – 28 days) after drug withdrawal;
  • The contraceptive can reduce tolerance to carbohydrates, increase the need for insulin or oral antidiabetics.

Breastfeeding and pregnancy

The use of Enskyce during pregnancy and during breastfeeding is contraindicated.

During the period of breastfeeding, a doctor should decide whether to cancel the drug or stop breastfeeding.

What if I miss a pill?

The contraceptive should be taken without missing the days, at the same time of a day. Otherwise, its effect on the body can be reduced.

If you missed an active pill (1-21 pills):

  • If a delay does not exceed 12 hours, the drug is used according to the basic scheme, there is no need to use additional birth control methods;
  • If a delay exceeds 12 hours, it is necessary to take 2 pills the next day and then use the medication according to the basic scheme. But at the same time it will be necessary to use additional birth control methods for 7-14 days. It is also recommended to take other contraceptive measures.

If you missed an inert pill (22-28 pills):

  • You may not worry and just throw it away. Continue taking the next pills according to the basic scheme.


  • The drug does not protect against sexually-transmitted diseases;
  • Before taking Enskyce pills and every 6 months during treatment, a general medical and gynecological examination is recommended (including gynecological control, examination of the mammary glands, liver function, blood pressure control and cholesterol concentration in the blood, urine analysis);
  • Smoking women have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on the age (especially in women older than 35 years) and on the number of cigarettes smoked;
  • The release of milk may decrease during the breastfeeding period. Ethinyl estradiol and desogestrel in small quantities are excreted in breast milk. The contraceptive increases the risk of thrombosis in women who have undergone surgical intervention or prolonged immobilization. Women who have chloasma should avoid exposure to the sun.


This pill is fantastic! I’ve been taking it for about 5 months now and have had no problems except minor anxiety. I have lost some weight on this medicine as well! The pill makes my periods less painful and less abundant. I’ve had no problem with libido. I definitely recommend Enskyce to anyone who is looking for a new contraceptive.
- Cleo Brown

I have had none of the side effects that others have described above. I've been taking this contraceptive for a year now. I only had very slight breast tenderness when on my first pack, but very soon my body adjusted to the product.
- Maria Yarbrough

I've been taking this pill for about 6 weeks. I've been depressed, angry, and feel like crying all the time. My doctor said I’ll be fine it’s just my body getting used to the contraceptive. I haven’t had weight gain! I’m very happy.
- Laverne Martin

I absolutely LOVE this pill. I have had NO side effects. I have taken so many other BC pills in the past and nothing worked well; I was depressed, anxious, moody all the time... However, Enskyce works for my body. Girls, give it a go. Some pills work different for some people, but you never know until you try.
- Melissa Yamamoto

It gave me full blown depression. It made me lose my libido, no interest whatsoever in sex, couldn’t even get wet if I tried. Started getting intrusive thoughts and lost interest in a lot of my hobbies. Took Enskyce for over 6 months. Please do not do this to yourself ladies ♥️
- Lola R

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