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Juleber Review

Juleber is a combination contraceptive containing 2 hormones, desogestrel and ethinyl estradiol, which prevents ovulation.


Indications for use

  • Oral contraception.

Mechanism of action

The contraceptive effect of Juleber is based primarily on the ability to suppress ovulation and increase the secretion of cervical mucus.

Desogestrel inhibits the synthesis of gonadotropic hormones, thus, prevents the maturation of the follicle (blocks ovulation).

Ethinyl estradiol, a synthetic analogue of the follicular hormone estradiol, regulates the menstrual cycle.

Also, the drug increases the viscosity of the mucus in the cervix, which makes it difficult for sperm to enter the uterus.

In addition to the contraceptive properties, the preparation normalizes menstrual-like reactions, making them less painful, and decreases the frequency of concomitant iron deficiency anemia.

Dosage and mode of application

Juleber pills are taken regardless of the meal, once a day, at about the same time of day (every 24 hours).

Take the drug in the order indicated on the reverse side of the blister, for 28 days in a row.

Start the next pack without interruption. “Withdrawal bleeding” begins in the period of taking inert pills.

If you did not take contraceptive drugs in the last month, take the 1st pill on the 1st day of the menstrual cycle (on the day when the menstrual bleeding begins). It is possible to start taking pills 2-5 days later but in this case, you should resort to backup methods of contraception during the first seven days.

If you need to take Juleber after an abortion in the first trimester of pregnancy, you can do it immediately. Additional contraception is not required. After delivery or an abortion in the second trimester, you can start taking pills on the 21-28th day. If you started taking tablets later, it is necessary to use other methods of contraception during the first week.

When switching from other oral contraceptives, you can start taking the drug on any day, additional methods of contraception are not required.


The serious consequences of an overdose of Juleber tablets have not been reported. If you take several pills at once, you may experience nausea, vomiting and vaginal bleeding. If you find that your child has swallowed a pill, consult a doctor.

Side effects

In some case, the contraceptive can cause the following side effects:

  • gastralgia;
  • headache;
  • thromboembolism;
  • nausea;
  • change in glucose tolerance;
  • a decrease in hearing;
  • vomiting;
  • cholestatic jaundice;
  • swelling;
  • dry eye mucosa;
  • chloasma;
  • breast engorgement;
  • erythema nodosum;
  • breast tenderness;
  • visual impairment;
  • generalized itching;
  • increased blood pressure;
  • conjunctivitis;
  • “flies” before eyes;
  • smearing secretions;
  • thrombophlebitis;
  • cholelithiasis;
  • changes in vaginal secretion;
  • increase in body weight;
  • hepatocellular adenoma.


You should not take Juleber for birth control if you have at least one of the diseases or conditions listed below. This should be reported to the doctor before making a decision about taking the contraceptive

  • thrombosis (venous or arterial), including a history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke);
  • clinical manifestations of thrombosis (ischemic disease or angina), including a history;
  • diabetes mellitus with vascular lesions;
  • severe or multiple risk factors for venous or arterial thrombosis;
  • severe liver disease, including a history;
  • benign and malignant liver tumors, including a history;
  • an established or suspected hormone-dependent malignant tumor of the genitals or mammary glands;
  • vaginal bleeding of unknown etiology;
  • established or suspected pregnancy, lactation;
  • hypersensitivity to desogestrel/ethinyl estradiol or other components of the drug;
  • a migraine with focal neurological symptoms;
  • hypertriglyceridemia.

If the drug is used against the background of one of the following conditions, you may need to be monitored regularly by a doctor. Before you start taking birth control pills, be sure to tell your doctor about the following conditions/diseases:

  • smoking;
  • migraine;
  • epilepsy;
  • diabetes;
  • overweight;
  • high blood pressure;
  • heart valve disease or heart rhythm disorder;
  • inflammation of the veins (surface thrombophlebitis);
  • varicose veins;
  • a family history of thrombosis, myocardial infarction, or stroke;
  • high cholesterol or triglyceride level;
  • one of the closest relatives had breast cancer;
  • liver or gallbladder disease;
  • Crohn’s disease or ulcerative colitis (chronic inflammatory bowel disease);
  • systemic lupus erythematosus;
  • hemolytic uremic syndrome (a bleeding disorder that causes renal failure);
  • sickle cell anemia;
  • chloasma (yellow-brown patches of skin pigmentation), including a history. In this case, prolonged exposure to sunlight or ultraviolet radiation should be avoided.


In order to prevent a decrease in the contraceptive effect, it is recommended not to combine Juleber tablets with the following drugs:

  • rifampicin;
  • isoniazid;
  • ampicillin;
  • penicillins;
  • hydantoin;
  • topiramate;
  • griseofulvin;
  • chloramphenicol;
  • tetracycline;
  • oxcarbazepine;
  • felbamate;
  • neomycin;
  • adsorbents (simultaneous reception is contraindicated);
  • barbiturates;
  • carbamazepine.

Juleber can reduce the effectiveness of diazepam, anticoagulants, purine alkaloids, antidepressants, hypoglycemic agents, glucocorticosteroids, clofibrate.

Pregnancy and breastfeeding

This drug is contraindicated for use during pregnancy or suspected pregnancy.

The active components of the contraceptive can penetrate into breast milk, therefore Juleber cannot be used as a contraceptive during lactation.

What if I miss a pill?

Missing active tablets increases the risk of getting pregnant.

If you forgot to take a pill on time:

  • a delay does not exceed 12 hours: take the missed tablet as soon as you remember, take the next one at the usual time;
  • a delay exceeds 12 hours: take the missed tablet at the usual time, use barrier methods of contraception in the next 7 days.


When using Juleber, it’s recommended to undergo systematic medical examinations every 6 months.

Smokers over the age of 35 should stop smoking if they intend to use these pills for contraception.

Estrogen-containing drugs may temporarily increase the risk of thrombosis in patients undergoing surgery and prolonged immobilization.

In women with a tumor-like formation in the abdominal cavity and/or acute abdominal pain, a hepatocellular adenoma should be excluded.

Women who have chloasma should avoid exposure to the sun.

Vomiting and diarrhea that occur 3-4 hours after taking an active tablet can reduce its absorption and effectiveness. You should use backup methods of contraception in the next 7 days.

Combination oral contraceptives do not affect the patient’s ability to drive vehicles and operate mechanisms.

Patients under the age of 18 should not use this drug, because the safety and efficacy of Juleber in adolescents have not been studied.

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