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MonoNessa Review

MonoNessa is a combined birth control preparation containing two female hormones suppressing and preventing ovulation.


Indications for use

  • Unwanted pregnancy prevention;
  • Acne treatment.

Mechanism of action

  • Decrease in serum concentration of luteinizing hormone (LH) and follicle-stimulating hormone (FSH);
  • Direct suppression of LH in the middle of the cycle takes place;
  • Reduction in the synthesis of endogenic estrogens and progesterone: suppression of ovulation; the impossibility for spermatozoa to stick to the fallopian tube;
  • Formation of dense viscous mucus with cervical glands, making it difficult for sperm to pass through the female genital tract.

Mode of application and dosage

For oral administration. MonoNessa dosage regiment: 1 pill/day for 21 days containing hormones + 7 free of hormones pills. The interval between doses of the drug should not exceed 36 hours. Birth control pills are most effective if taken at the same time of the day, for example, in the morning.


  • Venous thrombosis;
  • Arterial thrombosis, including in the anamnesis (acute disorders of cerebral circulation, myocardial infarction, retinal arterial thrombosis);
  • Hereditary predisposition to thrombosis including arterial one;
  • Arterial hypertension;
  • Diabetes mellitus with vascular damage;
  • Hereditary dislipoproteinemia;
  • Hypersensitivity to drug components;
  • Migraine with aura;
  • Cerebrovascular diseases;
  • Breast carcinoma and other estrogen-dependent formations;
  • Liver failure;
  • Hemolytic anemia;
  • Benign or malignant liver tumors;
  • Otospongiosis;
  • Cholestatic jaundice during pregnancy, including in the anamnesis;
  • Sickle-cell anemia;
  • Cardiac ischemia;
  • Intermenstrual bleeding of unclear etiology;
  • Postmenopausal period;
  • Age under 18 years;
  • Postpartum period including the first 4 weeks;
  • Pregnancy and lactation.

It is contraindicated in smoking women especially if they are over 35 years old.

Side effects

  • Menstruation-like hemorrhage;
  • Vaginal spotting;
  • An increase in vaginal secretion;
  • Vaginal candidiasis;
  • Cervical erosion.

There may be an increase or decrease in body weight, breast tenderness, discharge from the nipples; nausea, vomiting; migraine, headache; depression; skin rash. If you find these symptoms, you should consult your doctor.


  • The metabolism enhancement of steroid hormones in case of simultaneous intake of St. John’s wort, barbiturates, carbamazepine, phenytoin, sulfonamides, pyrazolone derivatives, rifampicin.
  • The violation of intrahepatic circulation of estrogens, as a result of which the excretion is accelerated and the concentration of ethinyl estradiol is reduced. When such a combination is used with certain antibiotics (eg, ampicillin or tetracycline), an insufficient breakdown of estrogens’ conjugates and fatty acids by intestinal bacteria is observed.
  • It has been shown that some protease inhibitors and some antiretroviral drugs increase (for example, indinavir) or reduce (for example, ritonavir) the concentration of combined hormonal contraceptives.
  • When taking hypoglycemic medications at the same time with MonoNessa, you may need to adjust the dose of the latter.

What if I miss a dose?

If you miss the habitual time of administration, MonoNessa pill should be taken immediately. The delay in the usual regimen up to 12 hours provides a reliable contraceptive effect. The effectiveness of the drug decreases with a delay in taking the tablet for more than 12 hours.

If the usual time of taking the drug is more than 12 hours or more than one pill is missed, the drug application should be immediately restored leaving a missing tablet in the package. However, before the end of this cycle, additional means of protection from pregnancy, such as a condom or vaginal contraceptive suppositories, should be used. In such situations, one cannot rely on the method of “safe days” or “temperature” method of contraception.

Ortho-Cyclen and pregnancy

MonoNessa category in the FDA is X. The drug is contraindicated during pregnancy.

Epidemiological studies have not revealed an increase in the risk of birth defects in children whose mothers before the pregnancy have taken birth control pills. Most modern studies have also not revealed teratogenic effects, in particular, cardiac dysfunctions and shortening of limb, in children of women who mistakenly took oral contraceptives during pregnancy.

Combined oral contraceptives can affect lactation, that is, reduce the amount and change the composition of breast milk. In addition, a small portion of contraceptive steroids and/or their constituents can enter the breast milk. In connection with this, MonoNessa is contraindicated in the period of breastfeeding.

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