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Estarylla Review

Estarylla is a low-dose combination contraceptive used to prevent unwanted pregnancy. The drug contains two female hormones: norgestimate and ethinyl estradiol.


Indications for use

  • Prevention of unwanted pregnancy.
  • Treatment of severe acne

Mechanism of action

The drug suppresses ovulation due to the inhibition of the synthesis of gonadotropic hormones, the suppression of the hypothalamic-pituitary system. The silage is able to change the implantability of the endometrium, reduces the transport function of the fallopian tubes, increases the viscosity of cervical mucus.

Mode of application and dosage

Each package of Estarylla contains 28 pills – 21 active pills with hormones and 7 pills with no medication (known as “reminders”).

The pills are taken daily for 28 days in a row, without interruption. Take the 1st pill on the first day of the menstrual period. Menstrual bleeding is expected to come after you have taken the last active pill from the package. As soon as you take the last pill from the package, start a new one.

You can start taking the drug 7 days after the childbirth or immediately after the abortion.

It is desirable to take the pills at the same time every day.


Do not take Estarylla pills if you have any of the conditions listed below:

  • thrombophlebitis (inflammation of the vein wall with occlusion);
  • thromboembolism (vascular obstruction);
  • deficiency of antithrombin 3 (one of the factors that prevent blood clotting), cerebrovascular disorders (changes in brain vessels);
  • cardiac ischemia;
  • sickle-cell anemia (hereditary hemolytic anemia);
  • carcinoma (cancer) of the breast and endometrium (inner layer of the uterus), other estrogen-dependent neoplasms;
  • bleeding from the urogenital tract (genitourinary tract) of unknown etiology;
  • pregnancy;
  • breastfeeding;
  • impaired liver function;
  • tumor of the liver

Estarylla is not recommended for smoking women over the age of 35.

Side Effects

Stop taking the birth control pills if you have any of the side effects listed below:

  • irregular spotting (especially in the first months);
  • digestive system – violations of the liver, nausea, vomiting, itching, jaundice, rarely – liver adenoma, pathology of the gallbladder;
  • central nervous system – headache, migraine, depression;
  • skin reactions – hair loss, pigment spots on the face;
  • sense organs – discomfort when wearing contact lenses;
  • sexual system – cervical erosion, vaginal candidiasis, increased secretion of uterine mucus;
  • endocrine system – spotting, menstrual-like bleeding, amenorrhea, discharge from the nipples, engorgement of the mammary glands, changes in
  • libido, increase or decrease in body weight;
  • other: allergic reactions; rarely – reduced tolerance to glucose, increased blood pressure, increased uterine fibroids.

Do not discontinue using Estarylla when menstrual bleeding occurs. If bleeding does not stop, then an additional examination should be conducted to exclude organic pathology. If the bleeding does not occur after you have finished the package, you should exclude pregnancy before taking a pill from a new package.


Drugs that cause the induction of enzymes metabolizing estrogens (eg, estrogen-2-hydroxylase-coenzyme 3A4 of the cytochrome P-450 system) may reduce the contraceptive effectiveness of Estarylla.

Plant remedies that affect the enzymes involved in the biological transformation of contraceptive steroid hormones (eg, St. John’s Wort, barbiturates, carbamazepine, phenytoin, sulfonamides, pyrazolone derivatives, rifampicin) may also weaken the contraceptive effect of the drug.

Some protease inhibitors and some antiretroviral drugs (for example, indinavir, ritonavir) may increase or reduce the concentration of norgestimate and ethinyl estradiol in the blood.

Another type of interaction is the violation of intrahepatic circulation of estrogens, as a result of which the excretion is accelerated and the concentration of ethinyl estradiol is reduced. When Estarylla is taken with certain antibiotics (eg, ampicillin or tetracycline), insufficient cleavage of conjugates of estrogens and fatty acids by intestinal bacteria is observed.

What if I miss a dose?

If you forgot to take a pill but no more than 12 hours passed, contraception remains effective. If the interval exceeds 12 hours, the effectiveness decreases and it is necessary to use additional contraception methods.

Estarylla and pregnancy

Estarylla is contraindicated for pregnant women. When used in the early stages of pregnancy, the drug can cause malformations in the fetus.

During breastfeeding, a small amount of norgestimate and ethinyl estradiol are excreted in breast milk. The negative impact on the child’s body is not established. However, gynecologists and pediatricians do not recommend using this hormonal contraceptive during breastfeeding. During this period, you should use non-hormonal birth control means.

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