Tri-Lo-Marzia is a combination hormonal contraceptive which is used to prevent pregnancy. The drug contains 2 hormones, ethinyl estradiol and norgestimate.
- Hormonal contraception.
The drug affects the hypothalamic-pituitary system, inhibits the production of gonadotropic hormones, suppresses ovulation, changes the implantation ability of the endometrium.
Each pack of Tri-Lo-Marzia contains 28 pills:
- 7 pills each containing 0.18 mg/25 mcg;
- 7 pills each containing 0.215 mg/25 mcg;
- 7 pills each containing 0.25 mg/25 mcg;
- 7 inert pills.
Take the first pill on the first day of your period, then take 1 tablet per day for 28 days in a row. Menstrual-like bleeding occurs a few days after taking the last active pill. The next pack should be started immediately. The time of the first dose does not matter, however, the subsequent doses should be made at the same selected hour, preferably after breakfast or dinner (to ensure a constant concentration of ethinyl estradiol and norgestimate in the plasma, the interval between doses should not exceed 36 hours).
Overdosage can cause vomiting, nausea, and vaginal bleeding. There is no specific antidote. In case of overdose, it is necessary to do a gastric lavage (within the first hour after taking the active tablet) and receive a symptomatic therapy.
Tri-Lo-Marzia can cause the following side effects:
- breast tenderness;
- swelling of the abdomen;
- water retention;
- high blood pressure;
- abnormally long or heavy menses;
- reduced libido;
- enlarged breasts;
- lack of menses, irregular periods, painful periods;
- tumor of liver cells;
- bleeding not related to a menstrual period;
- blood clot;
- change in appetite;
- trouble sleeping;
- excessive hairiness;
- fluid retention;
- hair loss;
- depressive mood;
- muscle spasm;
- painful periods;
- vaginal dryness;
- breast tumor;
- disease of the gallbladder;
- heart attack;
- inflammation or infection of the vagina;
- kidney disease;
- allergic reaction;
- neoplasm of the liver;
- retinal thrombosis;
- vision disorders;
- anemia and renal failure;
- trouble breathing;
- yellowing of skin or eyes;
- abdominal pain;
- weight changes;
- yeast infection of vagina and vulva;
- yellow-brown spots on the skin.
Do not take Tri-Lo-Marzia if you have:
- uncontrolled hypertension;
- pregnancy or breastfeeding period;
- liver disease or liver cancer;
- severe migraine headaches, especially if you are over 35 of age;
- heart disease (coronary artery disease, history of heart attack, stroke, blood clot);
- a hereditary blood disorder;
- circulation problems;
- hormone-related cancer in the anamnesis;
- cancer of the breast, uterus/cervix, or vagina in a history;
- unusual vaginal bleeding;
- if you are treated with any hepatitis C medication containing ombitasvir, paritaprevir, or ritonavir.
- high cholesterol or triglycerides,
- heart problems;
- predisposition to blood clots;
- a seizure or a migraine headache;
- gallbladder disease;
- liver or kidney disease;
- irregular menstrual cycles;
- fibrocystic breast disease;
- lumps, nodules;
- an abnormal mammogram;
- jaundice caused by the previous pregnancy or oral contraceptives.
A list of medications that may interact with Tri-Lo-Marzia includes:
- drugs used to treat seizures (barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate);
- aromatase inhibitors (anastrozole, exemestane);
- tranexamic acid;
- rifamycins (rifampin, rifabutin);
- St. John’s wort;
- HIV drugs (nelfinavir, nevirapine, ritonavir), and others.
Besides, combination oral contraceptives may affect certain laboratory tests (blood clotting factors, thyroid).
This medication is used to prevent pregnancy and should not be used in pregnant women. Stop taking the tablets if you become pregnant.
- If you missed 1 tablet in Weeks 1, 2, or 3, take it as soon as possible, then keep taking 1 tablet per day until the pack is empty;
- If you missed 2 tablets in a row in Week 1 or Week 2, take the 2 missed tablets as soon as you remember and the 2 tablets the next day. Then keep taking 1 tablet per day until the pack is empty. Use additional barrier contraception methods if you have sex within 7 days after missing tablets;
- If you missed 2 tablets in Week 3 or if you missed 3 or more tablets in a row in Weeks 1, 2, or 3: Day 1 starters: Discard the rest of the tablets and start a new pack that same day; Sunday starters: Keep taking 1 tablet each day until Sunday, then discard the rest of the tablets and start a new pack that same day. Use additional barrier contraception methods if you have sex within 7 days after missing tablets.
Using hormonal contraceptives increases the risk of thromboembolism, myocardial infarction or stroke. In some cases, the increased risk of these complications persists for several years after the end of hormonal contraception. The risk increases significantly with age, especially among heavy smokers (15-20 cigarettes per day). For this reason, it is not recommended to take Tri-Lo-Marzia for birth control if you are a smoker over the age of 30. Non-smoking women who do not have contraindications may take this drug until menopause.
Women suffering from the following diseases can take this drug only under strict medical control: cardiac or hepatic impairment, hypertension, fluid retention, diabetes, decreased glucose tolerance, bronchial asthma, gallbladder disease, varicose veins, uterine fibroma, depression, epilepsy.
Use of the contraceptive should be stopped if you become pregnancy, have an unusually severe migraine-like headache, acute vision or hearing loss, first signs of thrombophlebitis or thromboembolic complications, epileptic seizures or increased seizures, jaundice and / or full body itching, high blood pressure, fibroids growth, an increase in the size of the liver with suspected liver tumor, a prolonged period of immobilization (for example, after injury or before surgery).
The medication must be canceled 6 weeks prior to the scheduled surgery.
If vomiting or diarrhea occurs, the pill may lose its effectiveness since it takes 4 hours for the body to fully absorb the pill. In this case, it is recommended to continue taking the tablets and additionally use other, non-hormonal contraceptives before the onset of the period.