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Tri-Lo-Marzia Review

Tri-Lo-Marzia is a combination hormonal contraceptive which is used to prevent pregnancy. The drug contains 2 hormones, ethinyl estradiol and norgestimate.


Indications for use

  • Hormonal contraception.

Mechanism of action

The drug affects the hypothalamic-pituitary system, inhibits the production of gonadotropic hormones, suppresses ovulation, changes the implantation ability of the endometrium.

Dosage and mode of application

Each pack of Tri-Lo-Marzia contains 28 pills:

  • 7 pills each containing 0.18 mg/25 mcg;
  • 7 pills each containing 0.215 mg/25 mcg;
  • 7 pills each containing 0.25 mg/25 mcg;
  • 7 inert pills.

Take the first pill on the first day of your period, then take 1 tablet per day for 28 days in a row. Menstrual-like bleeding occurs a few days after taking the last active pill. The next pack should be started immediately. The time of the first dose does not matter, however, the subsequent doses should be made at the same selected hour, preferably after breakfast or dinner (to ensure a constant concentration of ethinyl estradiol and norgestimate in the plasma, the interval between doses should not exceed 36 hours).


Overdosage can cause vomiting, nausea, and vaginal bleeding. There is no specific antidote. In case of overdose, it is necessary to do a gastric lavage (within the first hour after taking the active tablet) and receive a symptomatic therapy.

Side effects

Tri-Lo-Marzia can cause the following side effects:

  • acne;
  • breast tenderness;
  • dizziness;
  • swelling of the abdomen;
  • water retention;
  • depression;
  • high blood pressure;
  • abnormally long or heavy menses;
  • reduced libido;
  • enlarged breasts;
  • headache;
  • lack of menses, irregular periods, painful periods;
  • tumor of liver cells;
  • bleeding not related to a menstrual period;
  • blood clot;
  • backache;
  • change in appetite;
  • trouble sleeping;
  • diarrhea;
  • excessive hairiness;
  • anxiety;
  • fluid retention;
  • hair loss;
  • hives;
  • itching;
  • depressive mood;
  • muscle spasm;
  • painful periods;
  • rash;
  • vaginal dryness;
  • breast tumor;
  • cataracts;
  • disease of the gallbladder;
  • gallstones;
  • heart attack;
  • hepatitis;
  • inflammation or infection of the vagina;
  • kidney disease;
  • allergic reaction;
  • neoplasm of the liver;
  • pancreatitis;
  • retinal thrombosis;
  • stroke;
  • vision disorders;
  • anemia and renal failure;
  • trouble breathing;
  • fainting;
  • yellowing of skin or eyes;
  • abdominal pain;
  • migraine;
  • weight changes;
  • yeast infection of vagina and vulva;
  • yellow-brown spots on the skin.


Do not take Tri-Lo-Marzia if you have:

  • uncontrolled hypertension;
  • pregnancy or breastfeeding period;
  • liver disease or liver cancer;
  • severe migraine headaches, especially if you are over 35 of age;
  • heart disease (coronary artery disease, history of heart attack, stroke, blood clot);
  • a hereditary blood disorder;
  • circulation problems;
  • hormone-related cancer in the anamnesis;
  • cancer of the breast, uterus/cervix, or vagina in a history;
  • unusual vaginal bleeding;
  • if you are treated with any hepatitis C medication containing ombitasvir, paritaprevir, or ritonavir.

With caution:

  • high cholesterol or triglycerides,
  • overweight;
  • depression;
  • heart problems;
  • hypertension;
  • predisposition to blood clots;
  • a seizure or a migraine headache;
  • diabetes;
  • gallbladder disease;
  • liver or kidney disease;
  • irregular menstrual cycles;
  • fibrocystic breast disease;
  • lumps, nodules;
  • an abnormal mammogram;
  • jaundice caused by the previous pregnancy or oral contraceptives.


A list of medications that may interact with Tri-Lo-Marzia includes:

  • drugs used to treat seizures (barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate);
  • aromatase inhibitors (anastrozole, exemestane);
  • ospemifene;
  • tranexamic acid;
  • ombitasvir/paritaprevir/ritonavir;
  • griseofulvin;
  • modafinil;
  • rifamycins (rifampin, rifabutin);
  • tamoxifen;
  • tizanidine;
  • St. John’s wort;
  • HIV drugs (nelfinavir, nevirapine, ritonavir), and others.

Besides, combination oral contraceptives may affect certain laboratory tests (blood clotting factors, thyroid).

Pregnancy and breastfeeding

This medication is used to prevent pregnancy and should not be used in pregnant women. Stop taking the tablets if you become pregnant.

What if I miss a pill?

  • If you missed 1 tablet in Weeks 1, 2, or 3, take it as soon as possible, then keep taking 1 tablet per day until the pack is empty;
  • If you missed 2 tablets in a row in Week 1 or Week 2, take the 2 missed tablets as soon as you remember and the 2 tablets the next day. Then keep taking 1 tablet per day until the pack is empty. Use additional barrier contraception methods if you have sex within 7 days after missing tablets;
  • If you missed 2 tablets in Week 3 or if you missed 3 or more tablets in a row in Weeks 1, 2, or 3: Day 1 starters: Discard the rest of the tablets and start a new pack that same day; Sunday starters: Keep taking 1 tablet each day until Sunday, then discard the rest of the tablets and start a new pack that same day. Use additional barrier contraception methods if you have sex within 7 days after missing tablets.


Using hormonal contraceptives increases the risk of thromboembolism, myocardial infarction or stroke. In some cases, the increased risk of these complications persists for several years after the end of hormonal contraception. The risk increases significantly with age, especially among heavy smokers (15-20 cigarettes per day). For this reason, it is not recommended to take Tri-Lo-Marzia for birth control if you are a smoker over the age of 30. Non-smoking women who do not have contraindications may take this drug until menopause.

Women suffering from the following diseases can take this drug only under strict medical control: cardiac or hepatic impairment, hypertension, fluid retention, diabetes, decreased glucose tolerance, bronchial asthma, gallbladder disease, varicose veins, uterine fibroma, depression, epilepsy.

Use of the contraceptive should be stopped if you become pregnancy, have an unusually severe migraine-like headache, acute vision or hearing loss, first signs of thrombophlebitis or thromboembolic complications, epileptic seizures or increased seizures, jaundice and / or full body itching, high blood pressure, fibroids growth, an increase in the size of the liver with suspected liver tumor, a prolonged period of immobilization (for example, after injury or before surgery).

The medication must be canceled 6 weeks prior to the scheduled surgery.

If vomiting or diarrhea occurs, the pill may lose its effectiveness since it takes 4 hours for the body to fully absorb the pill. In this case, it is recommended to continue taking the tablets and additionally use other, non-hormonal contraceptives before the onset of the period.


Do not take this contraceptive. This was my first time ever taking pregnancy prevention drugs. A week after taking it, I had my first panic attack ever happened in my life. After my first one, I had 3 since I've started taking it. Usually, after the attacks, I’ll feel normal the next day. But after my most recent one, I’ve been on edge and haven’t felt myself ever since. I’ve never had problems like this before and it started around the time I began taking this birth control. I stopped taking them, hopefully it leaves my body soon.
- Michelle Daniels

The first week was terrible with 24-hours' crying for no reason. I got terrible facial hair under my chin, they were dark wiry hairs. Since each week increases progestin rate the hair got worse weekly. As far as pregnancy prevention, it did fine but just terrible facial hair and headaches. Withdrawn it and went back to a monophasic pill.
- Hertha Carter

Tri Lo Mariza was the first contraceptive I had ever been taking. I found some changes with my mood, nothing complicated, but annoying. This birth control option did not affect on my weight, skin, but my period was definitely regulated, cramps were still very bad, but my period ended within 5 days. I was forced to exchange Tri Lo Mariza to Tri Lo Sprintec. But for a first birth control, I really didn't mind to use Tri Lo Marzia. It was completely efficient in preventing pregnancy when applied properly.
- Judith Trask

I’ve been applying Tri-Lo-Marzia for about 3 months now. I started taking it and for mainly day 1 period cramps and acne appeared. At first, this birth control made me gain about 10 pounds, but since then my weight has just been inconsistent. Surprisingly it got rid of the acne, but I’ve also been taking better care of my skin and haven’t put on makeup for a longer period of time. But the reason I’m taking my time to leave a review is that I used to have 3-4 day long periods and I’m now on DAY 7. It’s not even ample periods, but it’s not light enough to be spotting and it makes me annoying. I am over with this birth control option that and I used an IUD.
- Marilyn Cook

I have been on Tri-Lo-Marzia for 6 months. I've read lots of negative comments from women about really bad side effects when on the pill. However, through the 6 months of being on the pill, I have not experienced any adverse reactions.
- Sara

When I started birth control, my friend was sure that I would get side effects. After 2 years on Tri-Lo-Marzia I have not noticed any side effects. I have never missed a pill and have so far never had any issues. I would definitely recommend this pill.
- Mary

This was my first birth control pill. I've been taking it from the age of 19 (I'm now 25). I've always had severe acne and painful periods. This pill didn't improve my skin bur reduced pain during menstruation. I'm considering switching now because after 6 years, I'd really like to overcome acne!! Overall, I would recommend this medication, but I also think there are better options on the market.
- Gretha

Overall, I was happy with this birth control option, besides the headaches it gives me sometimes. My acne got MUCH better. When I started birth control, I had severe acne for 3 months, but it stopped after Tri-Lo-Marzia. I'd recommend this pill for those who want to get rid of acne
- Jessica

After switching to this birth control, my skin cleared within the first month but it gave me depression and anxiety! Beware!
- Eve

I've been taking Tri-Lo-Marzia for a month. I was switching from ortho-tri-cyclen-lo. Well. I have not gained any weight, have the same skin, appetite, sex drive. A first few days however I felt a little different - more unstable. Now I'm ok. In general, I'm satisfied!
- Veronika

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