Tri Femynor is a triphasic low dose means to prevent pregnancy. This drug is prescribed to protect herself from an unwanted pregnancy.
Indications for use
Tri Femynor is prescribed to women to control conception.
Mechanism of action
Tri Femynor has performed the functions by means of mechanisms: central and peripheral.
According to the central mechanism, this birth control drug provokes a sudden decrease in the secretion of a gonadotropin-releasing factor. This decrease results in inhibition of the FSH production by the pituitary gland (due to exogenous estrogen) during the proliferative phase. This inhibition delays the growth and maturation of the follicles in the ovaries. Exanthropic progestins suppress the LH secretion by the pituitary gland. This suppression contributes to suppression of ovulation. There is a decrease in the synthesis of endogenous estrogen and progestin.
Within the peripheral mechanism, this drug levels up the cervical mucus viscosity. It makes it difficult for sperm to penetrate the uterine cavity.
The reduced peristalsis of the fallopian tubes results in untimely penetration of a fertilized egg into the uterine cavity. Under the influence of combined estrogen-progestin drugs, there are changes in the endometrium structure. It, in turn, complicates the normal fertilized egg implantation.
Mode of application and dosage
Tri Femynor is prescribed for a daily regimen including 28 pills taken without interruption. Every pill is intended for an intake approximately at the same time. It is necessary to wash the pill down with a small amount of water The correct order is specified on the package. Taking the pills from the new package is started the day after taking the last tablet from the previous package.
If you feel vomiting, nausea or you have observed vaginal bleeding you may suppose it is an overdose. In case of overdose, it is mandatory to wash stomach (within the first hour after a possible overdose) and to carry out symptomatic therapy which is prescribed by your healthcare giver.
If you are going to start taking Tri Femynor, it is important to get acquainted with its contraindications listed below:
- currently diagnosed or prior transferred venous thrombosis inclusively of deep vein thrombosis and pulmonary thromboembolism;
- currently diagnosed or prior transferred arterial thrombosis including acute cerebrovascular accident, myocardial infarction, retinal artery thrombosis, angina pectoris or transient ischemic attack;
- arterial hypertension;
- cerebrovascular disorders;
- coronary heart disease;
- diabetes mellitus followed by vascular disease;
- genetic dyslipoproteinemia;
- hypersensitivity to any constituents of the drug;
- migraine with aura;
- breast and endometrium carcinoma or other estrogen-dependent neoplasms;
- hepatic failure;
- benign or malignant hepatic tumors;
- hemolytic anemia;
- sickle-cell anemia;
- bleeding of unclear genesis;
- postmenopausal period;
- age up to 18 years;
- puerperal period within 4 weeks;
- pregnancy and breastfeeding.
It is necessary to be careful if you have the following medical conditions:
- ulcerative colitis;
- extended immobilization or major surgery;
- risk factors for coronary heart disease, such as smoking, hyperlipidemia, hypertension, or obesity;
- uterine fibroids;
- dysfunctions of the liver and gallbladder;
- Crohn’s disease;
- systemic lupus erythematosus;
- kidney disease;
- acute abnormal liver function during a previous pregnancy or prior use of sex hormones;
- violations of the menstrual cycle.
- Cardiovascular system: increased blood pressure, heart attack, a disorder of cerebral circulation, deep vein thrombosis, arterial thromboembolism, edema.
- Hepatobiliary system: cholestatic jaundice, Budd-Chiari syndrome, intrahepatic cholestasis, cholelithiasis.
- Gastrointestinal tract: nausea, vomiting, abdominal pain, flatulence, colitis, anorexia.
- Genital organs: intermenstrual bleeding, spotting, amenorrhea, menstrual cycle changes, increase in uterine fibroids size, vaginal candidiasis, cervical secretion increase, cervical erosion, changes in libido, painful premenstrual syndrome, temporary infertility after the drug withdrawal.
- Breast glands: a sensation of tension, galactorrhea, increase in size, decrease in lactation when Tri Femynor is taken immediately after birth.
- Skin: erythema nodosum, skin rash, chloasma, exudative erythema, acne, seborrhea, alopecia, hirsutism, pigment facial spots, hypertrichosis.
- Organs of vision: cataract, the optic nerve lesion, change in the corneal curvature, discomfort when wearing contact lenses.
- CNS: headache, mood changes, irritability, depression, chorea, dizziness, migraine.
- Metabolism: fluid retention, changes in body weight (decrease or increase), decreased glucose tolerance, changes in appetite.
- Renal condition: decreased renal function, hemolytic-uremic syndrome.
- Tumors: benign and malignant tumors of the liver, cervical and breast cancer.
- Others: kidney disease, decreased libido.
There observed the increase in the metabolism of Tri Femynor when combining with:
- Hypericum perforatum;
- derivatives of pyrazolone;
When taken together with some antibiotics (for example, ampicillin or tetracycline), there is an insufficient cleavage of estrogen and fatty acids by intestinal bacteria.
Some protease inhibitors and some antiretroviral drugs have affected the increase or decrease in the concentration of combined hormonal contraceptives in the plasma.
When combining ethinyl estradiol and norgestimate with hypoglycemic drugs the dose adjustment of the latter may be required.
What if I miss a dose?
Thes recommendations belong to the missing of active pills only. If you forget to take placebo pill it can be just thrown away.
If a woman misses the pill containing hormones for less than 24 hours, the contraceptive reliability is not changed. A woman should take the missed pill in at the moment she understands the missing. Then, the regimen should be continued.
If a woman delays taking the pill containing hormones for more than 24 hours, the contraceptive reliability may be changed considerably. Remember the more pills you have missed within a monthly course the greater the risk to become pregnant.
Each blister contains the rules on how to act in the case of missing tablets. Tri Femynor is a triphasic drug that’s why the closer the missed pill to the end of the course the higher the risk of conceiving a child.
Tri Femynor and pregnancy
Tri Femynor has categorized in the FDA as X. This medication is contraindicated for an application by pregnant women.
The conducted epidemiological trials have not specified a high risk of birth dysfunctions in children if their mothers applied oral birth control before pregnancy. Most modern studies have not revealed any heart abnormalities and shortening of the extremities in children born by mothers taking hormonal birth control on the early stages of pregnancy.
Tri Femynor can influence breastfeeding. It reduces the quantity of breast milk changing its composition. Finally, women should consult a doctor when they are allowed to renew the course of contraceptives.