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Tri-Previfem Review

Tri-Previfem is a triphasic birth control medication. The main components are ethinyl estradiol and norgestimate.



Indications for use


Mechanism of action

Tri-Previfem is a triphasic combined hormonal contraceptive for oral administration. The drug action is achieved due to the mechanisms of central and peripheral spheres.

Suppressing the secretion of gonadotropins, this birth control drug prevents the maturation of eggs in the ovaries and ovulation, as a result.

In addition, Tri-Previfem increases the cervical mucus viscosity, which makes it difficult for sperm to penetrate the uterine cavity and acts on the endometrium cavity, decreasing the probability of egg attachment.

Mode of application and dosage

Tri-Previfem is prescribed for an oral administration. The course lasts for 28 days. As it is a triphasic preparation, the medication contains 3 doses of hormone. The hormone dosage should be taken daily at one and the same time predominantly in the evening. The pill should be washed down with a full glass of water. After the pills in a package are over, start a new one without a break. During the application of the latest 7 inert pills the menstruation will come.


  • Thrombophlebitis or thromboembolic disorders (including thrombophlebitis of deep veins, thromboembolic dysfunctions in the medical history);
  • antithrombin III deficiency;
  • Atherosclerosis of cerebral vessels;
  • Coronary sclerosis (myocardial infarction);
  • Sickle-cell anemia;
  • Diagnosed or suspected breast or uterine cancer, or other estrogen-dependent neoplasms;
  • Vaginal bleeding of unclear genesis;
  • Benign or malignant hepatic tumors;
  • Severe hepatic dysfunction;
  • Jaundice in the medical history;
  • Itching during pregnancy;
  • Herpes during pregnancy in the medical history;
  • Diagnosed or suggested pregnancy;
  • Lactation.


When using hormonal contraceptives, the risk of developing thromboembolism, myocardial infarction or stroke increases dramatically. In some cases, the increased risk of these complications persists for several years after the end of taking hormonal contraceptives.

The likelihood of such manifestations according to statistics increases significantly with age, especially among heavy smokers (smokers up to 15-20 cigarettes per day). For this reason, as a precautionary measure, it is not recommended to smoke women older than 30 years who take Tri-Previfem. Non-smoking women who do not have contraindications can take this birth control drug before the menopause onset.

Women suffering from the following diseases: violation of the heart or liver, arterial hypertension, fluid retention in the body, diabetes mellitus, a decrease in glucose tolerance, bronchial asthma, gallbladder disease, varicose veins, uterine fibroids, depression, epilepsy should be under medical supervision.

This drug intake should be discontinued in the case of a diagnosed or suggested pregnancy, an unusually strong, recurring or a migraine-like headache, acute visual impairment or hearing problems, the first signs of thrombophlebitis or thromboembolic complications, epileptic seizures, jaundice and/or whole body itching, with an increase in the arterial blood pressure, fibroids, increased liver size with diagnosed hepatic tumor, a long-lasting period of immobilization.

Side effects

  • Digestive system: nausea, vomiting, cholestatic jaundice, violations of the liver, accompanied by itching; rarely – gallbladder disease, hepatic adenoma.
  • Central nervous system: migraine, headache, depression.
  • Dermatological reactions: pigment spots on the face, hair loss.
  • Organs of senses: a feeling of discomfort when wearing contact lenses.
  • Reproductive system: vaginal candidiasis, cervical erosion, increased secretion of uterine mucus.
  • Endocrine system: menstrual-like bleeding, spotting, amenorrhea, a feeling of tension and tenderness of the mammary glands, allocations from the nipples; change in body weight (increase or decrease), change in libido.



The contraceptive effect of Tri-Previfem may decrease in women taking antibiotics (ampicillin, tetracycline, rifampicin), barbiturates, antiepileptic drugs (hydantoin, carbamazepine), griseofulvin and phenylbutazone.

The first manifestation of this interaction may be the appearance of menstrual bleeding. In such cases, other methods of contraception should be used.

What if I miss a dose?

If you skip the common time of administration, Tri-Previfem pill should be taken immediately. A delay from the usual time is less 12 hours a proper contraceptive effect is maintained.

The effectiveness of the drug is reduced when the delay in taking the tablet lasts more than 12 hours. If the usual time of taking the drug has been more than 12 hours or more than 1 tablet is missed, then to avoid the appearance of premature menstrual bleeding, immediately take the pill, leaving a missed pill in the package.

However, before the end of this cycle, additional means of protection from pregnancy, such as a condom or vaginal contraceptive suppositories, should be applied. In such situations, one cannot rely on the method of “safe days” or “temperature” method of contraception.

Tri-Previfem and pregnancy

The drug is contraindicated for use in an diagnosed or suggested pregnancy.

The use of hormonal contraceptives at an early stage of pregnancy can cause fetus malformations and developmental defects.

Small amounts of the drug may penetrate into breast milk. Influence of Tri-Previfem on an organism of the infant is unlikely. However, nursing mothers should not use hormonal contraceptives for oral administration until they stop breastfeeding.

During lactation of a nursing mother, it is recommended to use non-hormonal contraceptives.

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