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Lyza Review

Lyza is a progestin-only birth control pill containing norethisterone, which is used to prevent pregnancy.


Indications for use

  • Oral contraception

Mechanism of action

The drug acts on the endometrium, slowing its growth. Also, it relaxes the muscles of the uterus, increases the growth of mammary glands, reduces cyclic edema, suppresses ovulation.

The gestagenic agent causes transformation of the mucous membrane of the uterus from the proliferation phase to the secretory one, and after fertilization creates the necessary conditions for the implantation of a fertilized egg. Norethisterone reduces the excitability and contractility of the musculature of the uterus, stimulates the development of the end elements of the breast, suppresses the secretion of gonadotropins by the pituitary gland, preventing the maturation of follicles and ovulation.

Dosage and mode of application

Lyza contains only hormone – progestin. One 28-day pack contain 28 active pills without inert pills. Each pill contains a small dose of norethisterone – 0.35 mg.

Take 1 pill daily at the same time of the day, without interruption. Start taking pills from a new pack as soon as you finish the previous one.

With this drug, your periods may be irregular, or heavier/lighter than your usual period. You may also have spotting between periods. Continue taking the preparation if this happens.


  • Symptoms: nausea, vomiting, vaginal bleeding;
  • Treatment: symptomatic therapy.


Do not take Lyza for birth control if you have any of the following conditions:

  • hypersensitivity,
  • breast cancer,
  • pregnancy,
  • cholestatic jaundice in history,
  • jaundice,
  • acute liver diseases (including benign and malignant neoplasms),
  • acute thrombophlebitis or thromboembolism,
  • bleeding from the urinary tract of unknown origin,
  • metrorrhagia of unknown origin,
  • bleeding from the genital organs of an unknown genesis,
  • puberty.

With caution: bronchial asthma, CHF, epilepsy, arterial hypertension, migraine, renal failure, seizures or other abnormalities of the central nervous system, diabetes mellitus, liver disease, hyperlipidemia, thrombophlebitis in the anamnesis, thromboembolism in the anamnesis.

Side effects

Lyza pills can cause side effects. Tell your doctor if you have any of the following symptoms:

  • nausea;
  • vomiting;
  • metrorrhagia;
  • peripheral edema;
  • allergic reactions (skin rash, itching);
  • paresthesia;
  • weight gain;
  • fatigue;
  • breast engorgement.

With long-term use: thrombosis, thromboembolism.


Lyza tablets may interact with hypoglycemic drugs, oral anticoagulants, GCS.

It is not recommended to combine birth control pills with barbiturates, phenytoin, rifampicin, cimetidine and other drugs that affect microsomal oxidation in the liver.

What if I miss a dose?

Take the missed pill as soon as you remember. However, if it is almost time for the next dose, skip the pill and continue taking the drug in your usual dosing schedule. Do not take a double dose to make up for the missed one.

Lyza and pregnancy

This contraceptive is not used in pregnancy. When taken in the early period of pregnancy, the preparation does not produce a teratogenic effect and does not affect the development of the fetus.

Use of the drug in the postpartum period reduces the secretion of milk and changes its quality indicators.

Special instructions

If you resort to surgery, including dental surgery, tell the doctor or dentist that you are taking norethindrone. Tell your doctor if you are a smoker. Smoking (especially in women over 35) can increase the risk of serious Lyza side effects.

Before the treatment, it is necessary to exclude the presence of malignant neoplasms, to conduct preliminary thorough gynecological, oncological examination and examination of the mammary glands.

Impact on the ability to manage motor vehicles and mechanisms:

The medication does not affect the ability to drive vehicles and mechanisms that are associated with an increased risk of injury.

Use in violations of liver function:

The drug is contraindicated to people with violations of liver function, acute liver diseases (including benign and malignant neoplasms).

Use in children:

The contraceptive is contraindicated during puberty.

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