Jolivette is a progestine hormonal drug. The main component is norethisterone.
Contents:
Indications for use
Contraception. It also can be applied in the following cases:
- premenstrual syndrome;
- anovulatory metrorrhagia;
- infertility;
- miscarriage;
- dysmenorrhea (accompanied by a shortening of the secretory phase);
- algodismenorrhea;
- amenorrhea;
- endometriosis;
- adenomyosis;
- fibroids;
- mastodynia;
- mastopathy;
- endometrial glandular cystic hyperplasia;
- endometrial cancer;
- menopausal syndrome;
- diagnostic progesterone test;
- cessation and prevention of lactation;
- postponement of the next menstruation.
Mechanism of action
Jolivette is a progestogen. When entering the organism, Jolivette binds to the receptors of progesterone in target organs, including myometrium. Norethisterone in the cytoplasm of cells forms a complex with specific receptors that bind to the chromatin of target cells and changes the synthesis processes in them.
Norethisterone blocks the secretion of gonadotropin in the pituitary gland, thus preventing the onset of ovulation and maturation of the follicles, transferring the uterine lining from the proliferation phase to the secretory phase. Jolivette slows proliferative activity in the hyperplastic endometrium. It also promotes secretory transformation, development of atrophic changes in the stroma and epithelium of the glands and the decidual response of the stroma. After fertilization norethisterone promotes the transition of the mucous membrane of the uterus into a state that is favorable for the development of a fertilized egg.
Norethisterone reduces the contractility and excitability of the uterus muscles. Norethisterone increases the cervical mucus viscosity, thereby impeding the progress of sperm, disrupts the peristalsis of the fallopian tubes, reduces the sensitivity of the endometrium to the oocytes, thus disrupting the fertilized egg attachment. Many women do not have ovulation with norethisterone, which is confirmed by the lack of a peak increase in luteinizing hormone in the middle of the cycle and an increase in the level of progesterone.
Mode of application and dosage
As a contraceptive drug: 1.25-2.5 mg at night, from the 5th day of the menstrual cycle, daily for 28 days without a 7-day break, after which the reception of the next page according to the scheme should be done. In the first 14 days, the barrier contraceptive methods should be applied.
Contraindications
- Pregnancy;
- Thromboembolism;
- Thrombophlebitis (inflammation of the vein wall with their obstruction);
- Impaired cerebral circulation;
- Liver disease;
- Impaired liver function;
- Bleeding from the genital tract of an unknown etiology;
- Hormone-dependent tumors, including tumors of the mammary gland.
Side effects
- Nausea;
- Vomiting;
- Metrorrhagia;
- Peripheral edema;
- Allergic reactions (skin rash, itching);
- Paresthesia;
- Weight gain;
- Fatigue;
- breast tenderness.
In the case of a prolonged use, there is a high risk of thrombosis, thromboembolism.
Interactions
Take with cautious simultaneously with hypoglycemic drugs, oral anticoagulants, GCS.
It is not recommended to combine with barbiturates, phenytoin, rifampicin, cimetidine and other drugs that affect microsomal oxidation in the liver.
What if I miss a dose?
If you miss a regular tablet, it should be taken as soon as possible within the next 12 hours. When the delay in taking the drug for more than 12 hours, the missed tablet should be thrown away. Skipping the next dose can cause breakthrough bleeding or the appearance of spotting. Unused medication should be disposed of in accordance with local regulations.
Jolivette and pregnancy
Category at the FDA is X. Do not use Jolivette during pregnancy, virilization of female fetuses is possible. It also penetrates into breast milk. Depending on the type and dose, it can increase, decrease or not change the quality and quantity of breats milk. It is not recommended to use high doses during lactation.