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Aygestin Review


Indications for use

  • Premenstrual syndrome;
  • Dysfunctional uterine bleeding;
  • Dysmenorrhea;
  • Algomenorrhea;
  • Amenorrhea;
  • Endometriosis;
  • Myoma;
  • Endometrial cancer;
  • Mastodynia;
  • Mastopathy;
  • Infertility;
  • Miscarriage;
  • Contraception;
  • Menopause;
  • Diagnostic progesterone test.

Mechanism of action

It causes the transformation of the uterine mucosa from the proliferation phase to the secretory phase. After fertilization, this drug contributes to its transition to a condition favorable for the a fertilized egg development. It has poorly expressed estrogenic and androgenic properties. Aygestin reduces the excitability and contractility of the uterine muscles, stimulates the development of the terminal elements of the mammary gland.

Mode of application and dosage

The mode of application is defined on an individual basis. Depending on the indications and treatment regimen, the daily dose of Aygestin varies from 350 mcg to 30 mg.


  • A history of cholestatic jaundice during pregnancy;
  • Cirrhosis of the liver;
  • Benign hyperbilirubinemia;
  • Severe impaired liver function;
  • Neoplasms of the genitals and mammary glands;
  • Tendency to thrombosis.

Side effects

  • The digestive system: nausea, vomiting.
  • The endocrine system: uterine bleeding, weight gain, breast engorgement.
  • The side of metabolism: peripheral edema.
  • The central nervous system and peripheral nervous system: paresthesia, increased fatigue.
  • Allergic reactions: skin rash, itching.
  • Dermatological reactions: chloasma, melasma.


Simultaneous use with barbiturates, hydantoins, rifampicin, a decrease in the effects of norethisterone is noted.

What if I miss a dose?

No date provided. Contact your halthcare provider to get to know more about if you miss a dose.

Aygestin and pregnancy

During pregnancy, Aygestin should be used strictly according to indications. It inhibits lactation, therefore, if necessary, a woman should decide on the termination of breastfeeding when this medicine is prescribed.

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