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Demulen 1/50-21/28 Review



Indications for use

Hormonal contraception

Mechanism of action

Demulen 1/50 is a combined estrogen-progestogen drug providing a contraceptive effect. When taking this birth control drug, it suppresses the pituitary secretion of gonadotropic hormones. The contraceptive effect has a direct relation with several mechanisms. The estrogen component is ethinyl estradiol. It contains ethinodiol as a progestogen component. Under the influence of ethinodiol, there is a blockade of release of releasing factors (LH and FSH) of the hypothalamus. It also provides an inhibition of pituitary secretion of gonadotropic hormones, which leads to inhibition of follicular maturation and the release of an egg ready for fertilization (violation of the ovulation process). The contraceptive effect is enhanced by ethinyl estradiol. It increases the viscosity of cervical mucus. Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps to prevent the development of a number of gynecological diseases, and acne.

Mode of application and dose

Oral route administration: 1 tablet daily, starting from the 5th day of the menstrual cycle. If there are 21 tablets in the package, after taking the latter a 7 days break is followed. If the package contains 28 tablets, they are taken daily without interruption (7 tablets contain a preparation of ferrum or placebo). If menstruation is delayed, pregnancy should be excluded. When menstruation occurs, the drug is resumed 7 days after taking the last pill of the previous cycle. If, on the background of regular intake, menstruation has not occurred, the course is continued after exclusion of pregnancy.


  • Hypersensitivity;
  • Pregnancy.

Take this drug with caution in the following cases:

  • diseases of the liver and gall bladder;
  • epilepsy;
  • depression;
  • ulcerative colitis;
  • uterine fibroids;
  • mastopathy;
  • chorea;
  • tetany;
  • porphyria;
  • multiple sclerosis;
  • varicose veins;
  • tuberculosis;
  • kidney disease;
  • adolescence (without regular ovulatory cycles).


Side effects

  • Headache;
  • Gastralgia;
  • Nausea;
  • Vomiting;
  • Tenderness of the mammary glands;
  • Intermenstrual spotting;
  • Weight gain;
  • Fluid retention;
  • Changes in libido;
  • Mood changes;
  • Swelling of the eyelids;
  • Skin rash;
  • Erythema nodosum;
  • Conjunctivitis;
  • Discomfort when wearing contact lenses;
  • Impaired perception (visual impairment, hearing loss);
  • Thrombophlebitis;
  • Thromboembolism;
  • Generalized itching;
  • Cholestatic jaundice;
  • Cholelithiasis;
  • Increased blood pressure;
  • Amenorrhea;
  • Changes in the size of uterine fibroids;
  • Worsening manifestations of endometriosis;
  • Vaginal candidiasis,
  • Chloasma.



Demulen 1/50 reduces the effectiveness of oral anticoagulants, anxiolytics (diazepam), tricyclic antidepressants, guanethidine, theophylline, caffeine, vitamins, hypoglycemic drugs, clofibrate, glucocorticosteroids, paracetamol. Rifampicin, isoniazid, ampicillin, neomycin, penicillin, tetracycline, chloramphenicol, sulfanilamides, nitrofuran derivatives, griseofulvin, barbiturates, carbamazepine, pyrimidone, phenylbutazone, analgesics, anxiolytic drugs decrease blood pressure. Efficiency decreases with regular excessive use of ethanol.

What if I miss a dose?

After missing the intake of 1 tablet, 2 tablets are taken the next day. After missing the intake of 2 tablets, 2 tablets are taken over the next 2 days. After missing the intake of 3 tablets, the course is discontinued and resumed, starting from the 1st day of the next menstrual cycle. During all this time, it is recommended to use barrier contraceptive means.

Demulen 1/50 and pregnancy

Demulen 1/50 is contraindicated during pregnancy and breastfeeding.

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