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Zovia 1 / 35E Review

Zovia 1 / 35E is an oral contraceptive containing female hormones known as ethinyl estradiol and ethynodiol diacetate. The drug is used to prevent pregnancy.


Indications for use

  • Contraception.

Mechanism of action

Ethinyl estradiol and ethynodiol have a depressing effect on the gonadotropic (regulating activity of the gonads) function of the pituitary gland (an internal secretion gland located in the brain), which causes inhibition of ovulation (the exit of a mature egg from the ovary), and also improves the functional state of the endometrium (the inner layer of the uterus).

Dosage and mode of application

Each Zovia 1 / 35E pack contains 21 active tablets and 7 inert tablets (without hormones).

Take 1 tablet per day for 28 days in a row, without intervals. On day 22-28, menstrual bleeding occurs. You can take the pills on the “Sunday” schedule and the “fifth-day” schedule. ”

  • “Sunday” schedule: start taking the pills on the first Sunday after the onset of menstruation. If your menstrual period begins on Sunday, take the first tablet on the same day;
  • “Fifth-day” schedule: start taking the pills on the fifth day after the onset of menstruation.

After a long interval or when switching from another medication, the first tablet should be taken on the first day of the menstrual period.

Side effects

In some cases, Zovia 1 / 35E can cause the following side effects:

  • headache;
  • gastralgia;
  • nausea;
  • vomiting;
  • soreness and engorgement of the mammary glands;
  • intermenstrual bleeding;
  • weight gain;
  • fluid retention in the body;
  • changes in libido;
  • mood changes;
  • eyelid edema;
  • skin rash;
  • nodal erythema;
  • conjunctivitis;
  • unpleasant sensations when wearing contact lenses;
  • impaired perception (visual impairment, hearing loss, flickering before the eyes);
  • thrombophlebitis;
  • thromboembolism;
  • generalized itching;
  • cholestatic jaundice;
  • cholelithiasis;
  • increased blood pressure;
  • amenorrhea;
  • uterus;
  • aggravation of endometriosis;
  • vaginal candidiasis;
  • chloasma.


Zovia 1 / 35E is contraindicated for use in the following conditions:

  • age under 16,
  • pregnancy and lactation (breastfeeding),
  • severe liver dysfunction,
  • cerebrovascular (brain vessels) disorders,
  • breast cancer,
  • fibromyoma (benign tumor of the uterus body).

Important: smoking is not advisable.


  • Ethinyl estradiol and ethynodiol diacetate reduce the effectiveness of oral anticoagulants, anxiolytics (diazepam), tricyclic antidepressants, guanethidine, theophylline, caffeine, vitamins, hypoglycemic drugs, clofibrate, GCS, paracetamol;
  • Rifampicin, isoniazid, ampicillin, neomycin, penicillin, tetracycline, chloramphenicol, sulfonamides, nitrofuran derivatives, griseofulvin, barbiturates, carbamazepine, primidone, phenylbutazone, analgesics, anxiolytics, antimigraine drugs reduce the effectiveness of the contraceptive, contribute to the occurrence of “breakthrough” bleeding;
  • The efficiency of birth control pills decreases with regular excessive use of ethanol.

Pregnancy and breastfeeding

Zovia 1 / 35E is contraindicated for use in pregnancy and lactation (breastfeeding).

What if I miss a pill?

The likelihood of an unwanted pregnancy is minimal if you missed 1 active tablet but the effectiveness of the drug may decrease. If you forget to take the tablet at your usual time, you should take 2 tablets the next day. If you missed 2 tablets for 2 consecutive days, you should take 2 tablets per day for 2 days. Then, continue taking the pills as usual and use additional non-hormonal contraceptive drugs (barrier methods: condom, chemical spermicides) for the next 14 days or until another menstrual bleeding occurs. If you missed an inert tablet, just throw it away.


Vomiting or diarrhea can lead to the withdrawal of ethinyl estradiol and ethynodiol diacetate from the body, so if you have gastrointestinal disorders 1-4 hours after taking an active tablet, you should take an additional pill. If these symptoms persist for a longer time, you should temporarily use other birth control methods.

Treatment of gynecological diseases with Zovia 1 / 35E is strictly according to the doctor’s prescription.

The risk of cardiovascular complications increases with smoking (especially after 35 years).

Before taking the drug, it is necessary to consult the gynecologist.

The drug should be immediately canceled if you have the following symptoms: early signs of phlebitis (inflammation of the vein wall), thrombosis (clotting of blood vessels), embolism (vascular obstruction) – bloating, unusual pain in the legs, chest pain when breathing or coughing, a feeling of contraction in the chest; migraine, sudden hearing and vision impairments, motor disorders.

The contraceptive is canceled 6 weeks before the planned surgical procedures.

The risk of thrombosis increases with high blood pressure.

The medication is canceled with hepatitis, jaundice, itching, cholestasis (stasis of bile in the bile ducts), frequent epileptic seizures, primary or secondary porphyria (a disease associated with impaired porphyrin / pigment metabolism).

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