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Ethinyl Estradiol / Ethynodiol


Ethinyl Estradiol / Ethynodiol is a combination birth control pill which is used to prevent pregnancy. The contraceptive contains 2 hormones: ethinyl estradiol and ethynodiol, which are hormonal contraceptives.

Contents:

Indications for use

  • Contraception.

Mechanism of action

Ethinyl Estradiol + Ethynodiol has a contraceptive effect. The drug depresses the pituitary secretion of gonadotropic hormones, blocks the release of releasing factors of the hypothalamus, oppresses the pituitary gland by gonadotropic hormones, which leads to inhibition of the maturation of the follicle and the release of the ovum ready for fertilization (violation of the ovulation process). Besides, the preparation increases the viscosity of the cervical mucus (making it difficult for sperm to enter the uterine cavity), normalizes the menstrual cycle and helps prevent some gynecological diseases.

Dosage and mode of application

Start taking tablets on the 5th day of your menstruation, in the order indicated on the blister. After taking all the tablets from the third row, continue the course, taking the pills left in the first row. Then take a break for 7 days. The next cycle should start on the same day of the week as the first cycle of reception. The drug should be taken every day at the same time.

Side effects

Ethinyl Estradiol / Ethynodiol can cause the following side effects:

  • headache;
  • gastralgia;
  • nausea, vomiting;
  • generalized itching;
  • uterus;
  • soreness and engorgement of the mammary glands;
  • intermenstrual bleeding;
  • weight gain;
  • fluid retention in the body;
  • changes in libido;
  • mood changes;
  • eyelid edema;
  • cholestatic jaundice;
  • cholelithiasis;
  • increased blood pressure;
  • amenorrhea;
  • skin rash;
  • nodal erythema;
  • conjunctivitis;
  • unpleasant sensations when wearing contact lenses;
  • impaired perception (visual impairment, hearing loss, flickering before the eyes);
  • thrombophlebitis;
  • thromboembolism;
  • aggravation of manifestations of endometriosis;
  • candidiasis of the vagina;
  • chloasma.

Contraindications

Ethinyl Estradiol / Ethynodiol is contraindicated for use in the following cases:

  • pregnancy and lactation;
  • renal dysfunction;
  • severe diabetes mellitus;
  • tumors of the mammary glands and reproductive system;
  • acyclic spotting of unknown origin;
  • thrombophlebitis;
  • liver disease and related disorders of its function;
  • severe fat metabolism disorders;
  • sickle cell anemia;
  • thromboembolic disease.

Interactions

  • Ethinyl Estradiol / Ethynodiol reduces the effectiveness of oral anticoagulants, anxiolytics (diazepam), tricyclic antidepressants, guanetidine, theophylline, caffeine, vitamins, hypoglycemic drugs, clofibrate, GCS, paracetamol;
  • Rifampicin, isoniazid, ampicillin, neomycin, penicillin, tetracycline, chloramphenicol, sulfonamides, nitrofuran derivatives, griseofulvin, barbiturates, carbamazepine, pyrimidone, phenylbutazone, analgesics, anxiolytics, antimigraine drugs reduce the contraceptive effect and may cause “breakthrough” bleeding;
  • Efficiency decreases with regular excessive use of ethanol.

Pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and breastfeeding (lactation).

What if I miss a pill?

If you missed one pill, the probability of pregnancy is small, but it increases with every subsequent missed tablet. If you missed a pill, you should take 2 tablets the next day. If you missed 2 pills in a row, you may have spotting. In this case, take 2 tablets daily for two days. Then continue taking the drug in the normal mode. If the delay between doses exceeds 24 hours, you need to take use additional contraceptive methods until the end of the cycle.

Precautions

Before taking birth control pills and every 6 months, you need to undergo a general medical and gynecological examination (including breast examination).

The drug is not recommended to smoking women over 35 years of age and women over 40 years of age.

The effectiveness of the drug decreases with persistent vomiting, diarrhea.

The drug should be discontinued with prolonged immobilization and 3 months before the planned surgical intervention, as well as in the early postoperative period.

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