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Slynd Review

Slynd (drospirenone) is a progestin-only pill used by women to prevent pregnancy.


Indications for use

Slynd (drospirenone) has multidirectional properties: gestagenic, antiandrogenic, antigonadotropic, antimineralocorticoid. It is mainly used for contraception.

It may also be prescribed for:

  • Complex therapy for the prevention of postmenopausal osteoporosis;
  • Menopausal disorders (elimination of hot flashes, sweating);
  • Severe symptoms of PMS;
  • Treating acne, blackheads;
  • Folate deficiency;
  • Fluid retention in the body;
  • Involutional changes in the genitourinary tract (in women with an unremoved uterus).

IMPORTANT! Drugs with drospirenone are prescribed by a doctor. Do not self-medicate!

Mechanism of action

Drospirenone (a progestin) is a hormone that works to lower the risk of becoming pregnant primarily by suppressing ovulation. It also significantly reduces the likelihood of colon cancer, hyperplasia, and endometrial cancer during menopause. It fights sleep disturbance, irritability in premenstrual syndrome, depression.

Dosage and mode of application

Each Slynd pack contains 24 white active tablets and 4 green inactive tablets. Take one tablet per day for 28 days in a row. Take tablets daily at about the same time of the day so that the interval between 2 tablets is always 24 hours. Do not skip tablets.

Side effects

In some cases, Slynd can cause the following side effects:

  • Allergy;
  • Dizziness, headaches;
  • Arterial hypertension;
  • Puffiness;
  • Thrombophlebitis, thrombi in the veins of the retina, thromboembolism of the pulmonary artery or cerebral vessels;
  • Calculous cholecystitis;
  • Depression, apathy, drowsiness, insomnia;
  • Vomiting, nausea;
  • Weight jumps;
  • Decreased visual acuity;
  • Vaginal discharge (bloody or unusual consistency);
  • Decreased libido;
  • Chloasma;
  • Varicose veins, convulsions;
  • Galactorrhea;
  • Alopecia;
  • Pain in the mammary glands and swelling.

Overdose symptoms:

  • Nausea;
  • Vomiting;
  • Vaginal bleeding.


  • Allergic reactions to drospirenone;
  • Porphyria;
  • Propensity to form blood clots;
  • Liver failure;
  • Lactation (lactation period);
  • Vaginal bleeding of unknown origin;
  • Breast (or genital) cancer;
  • Pregnancy;
  • Thromboembolism or thrombophlebitis.


Drospirenone reduces the effectiveness of anabolic steroids and drugs that stimulate smooth muscle of the uterus.

It reduces the effectiveness of drugs that enhance liver enzymes (barbiturates, carbamazepine, oscarbazepine, hydantoin derivatives, primidone, rifampicin, topiramate, griseofulvin, felbamate).

Some antibiotics may affect drospirenone metabolism.

Pregnancy and breastfeeding

Slynd is contraindicated for use during pregnancy and during lactation (breastfeeding).

What if I miss a pill?

  • If you missed one white active tablet, take the missed tablet as soon as possible. Keep on taking one tablet a day until the pack is empty;
  • If you missed two or more white active tablets, take the last missed tablet as soon as possible. Keep on taking one tablet a day until the pack is empty (one or more missed tablet(s) will remain in the blister pack). You should use additional non-hormonal contraception (such as condoms or spermicide) if you have sex within 7 days after missing tablets;
  • If you missed one or more green inert tablets, throw them away and continue taking one tablet a day until the pack is empty.


The benefits of hormonal contraception should be assessed individually for each woman and discussed with her before using hormonal contraceptives.

In the case of a suspected or established venous or arterial thromboembolism, the use of hormonal contraceptives must be stopped. When initiating anticoagulant therapy, adequate alternative contraception should be started in order to avoid the teratogenic effect of anticoagulant therapy (coumarins).

The use of any oral contraceptive increases the risk of venous thromboembolism.

The results of epidemiological studies have allowed us to associate the use of hormonal contraceptives with an increased risk of developing arterial thromboembolism (myocardial infarction) or cerebrovascular accident (for example, transient ischemic attack, stroke). Arterial thromboembolic complications can be fatal.

Some epidemiological studies have shown an increased risk of developing cervical cancer in women who have received oral contraceptives for more than 5 years. However, there is no single point of view about the degree of influence of sexual behavior and other factors, such as human papillomavirus, on this disease.

It is recommended to monitor the serum potassium content during the first treatment cycle in patients with renal failure, especially while taking potassium-sparing drugs.

The drug can increase the risk of pancreatitis in women with hypertriglyceridemia or a hereditary predisposition to it.

Although many women experienced a slight increase in blood pressure when taking birth control pills, a clinically significant increase was rare. If the product causes arterial hypertension that cannot be corrected with antihypertensive drugs, the use of Slynd should be discontinued. As soon as blood pressure is normalized with antihypertensive drugs, the use of oral contraceptives can be resumed.

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