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Ulipristal Review

Ulipristal 30 mg is a tablet used for emergency birth control. It prevents pregnancy when taken within 120 hours after unprotected sexual intercourse.


Indications for use

  • Emergency contraception.

Mechanism of action

Ulipristal is a synthetic modulator. The drug has a specific effect on progesterone receptors. The principle of action is based on the suspension of the natural process of ovulation in women. The active substance retards the rupture of the follicle, provided it is taken right before the date of the proposed ovulation.

Dosage and mode of application

Ulipristal 30 mg tablet should be taken as soon as possible, but no later than 120 hours (5 days) after unprotected sexual intercourse or if the method of used contraception was unreliable.

The drug can be taken regardless of foods.

If you had vomiting or diarrhea 3 hours after taking the drug, you should take an additional tablet.

The preparation can be taken any day of the menstrual period. Before using the drug, pregnancy should be excluded.


  • Symptoms: the clinical experience of an overdose of ulipristal acetate is limited. At a single admission of up to 200 mg severe adverse events were not recorded. These high doses were well tolerated, however, the menstrual period in women was shorter (uterine bleeding started 2-3 days earlier than expected), in some women the duration of menstruation increased, while bleeding was moderate (smearing bleeding);
  • Treatment: there is no specific antidote, further treatment should be symptomatic.

Side effects

In some cases, Ulipristal 30 mg tablet can cause side effects:

  • psyche: emotional disorders, anxiety;
  • nervous system: headache, dizziness;
  • metabolism: weight gain;
  • the organ of hearing and balance: vertigo;
  • respiratory system: epistaxis;
  • digestive system: abdominal pain, nausea, dyspepsia, dry mouth, flatulence, constipation;
  • skin and subcutaneous tissue: acne, increased sweating, skin lesions;
  • musculoskeletal system: pain in the bones and muscles, back pain;
  • urinary system: urinary incontinence;
  • reproductive system and mammary glands: amenorrhea, thickening of the endometrium, tides, ovarian cyst, rupture of ovarian cysts, tension / tenderness of the mammary glands, metrorrhagia, pelvic pain, vaginal discharge, an increase and discomfort in the mammary glands;
  • the body as a whole: swelling, increased fatigue, astheniaю


Ulipristal acetate is contraindicated for use in the following cases:

  • hypersensitivity;
  • bleeding from the vagina of an unknown etiology;
  • cancer of the uterus, cervix, ovary or breast;
  • duration of therapy over 3 months;
  • bronchial asthma (severe form, not amenable to oral corticosteroids);
  • pregnancy;
  • breastfeeding;
  • age under 18 years.

With caution: elderly age, renal and hepatic insufficiency.


  • Hormonal birth control methods can reduce the contraceptive effect of ulipristal;
  • Ulipristal may interfere with the action of hormonal contraceptives (only gestagen-containing tablets, gestagen releasing systems or combined oral contraceptives) and progestogen drugs used for other indications. Therefore, the concomitant use of medications containing gestagen is not recommended;
  • Gestagen-containing drugs should not be used within 12 days after taking ulipristal;
  • The combined use of potent inhibitors of the isoenzyme CYP3A4 (ketoconazole, ritonavir, nefazodone) can lead to an increase of ulipristal content in the blood plasma;
  • The combined use of moderate or potent inhibitors of the CYP3A4 isoenzyme with ulipristal is not recommended.

Pregnancy and breastfeeding

  • Pregnancy: Ulipristal 30 mg tablet is contraindicated in pregnancy. Data on the use of the drug in pregnant women are absent or limited.
  • Breastfeeding period: Ulipristal penetrates into breast milk, so the emergency contraception is contraindicated during breastfeeding.


The drug is intended only for occasional use and should not replace the methods of regular contraception. In any case, a woman should be advised to use the methods of planned contraception.

Typically, the menstrual period resumes within 4 weeks after the end of the course of treatment.

Ulipristal 30 mg does not prevent pregnancy in each case.

If the next menstrual period is delayed for more than 7 days, you have an abnormal menstruation or symptoms of pregnancy, a pregnancy test should be done. If the pregnancy occurred after taking Ulipristal, ectopic pregnancy should be excluded. It is important to remember that the occurrence of uterine bleeding does not exclude ectopic pregnancy. Women who have done a pregnancy after taking the drug should consult a doctor.

The medication inhibits or delays the onset of ovulation. If ovulation has already occurred, the drug is ineffective. The time of ovulation cannot be predicted, so the tablet should be taken as soon as possible after unprotected sexual intercourse.

There are no data on the effectiveness of Ulipristal 30 mg tablet after its use after 120 hours (more than 5 days) after unprotected sexual intercourse.

Limited data suggest that the efficacy of the emergency contraception may decrease with increasing body weight or body mass index (BMI). All women, regardless of body weight or BMI, should use emergency contraception as soon as possible after unprotected intercourse.

Contraception after taking Ulipristal

This drug does not provide a contraceptive effect in subsequent sexual acts. Therefore, after using emergency contraception, a woman should be recommended to use a reliable barrier birth control method before the next menstrual period.

Despite the fact that the use of the preparation is not a contraindication to continuing routine hormonal contraception, ulipristal acetate may reduce the contraceptive effect of routine hormonal contraceptives. Therefore, if a woman wants to begin or continue using hormonal contraception, she can do this after taking an emergency contraception tablet. At the same time, she should use a reliable barrier birth control method until she has the next menstrual period.


This drug contains lactose. Patients with rare hereditary diseases of intolerance to lactose or glucose-galactose malabsorption syndrome should not take this drug.


Fertility is recovered quickly after the use of ulipristal as an emergency contraceptive.

Children and teenagers

The medication was not used in children according to the indication of emergency contraception.

The contraceptive can be used in women of reproductive age, including adolescents. The safety or efficacy of the drug in women aged under 18 years has not been identified.

Influence of the drug on the ability to drive a vehicle or work with potentially dangerous mechanisms

The drug can have an easy or moderate effect on the ability to drive vehicles and work with mechanisms since ulipristal may cause light or mild dizziness, drowsiness, blurred vision, attention impairment. The patient should be careful when driving vehicles and working with mechanisms after taking the tablet.

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